Sentences with phrase «for model validation»

It is recommended that this dataset should be used for analyses of precipitable water and for model validation over the oceans from 1988 onwards.

More accurate and reliable precipitation data would be invaluable, not only for the study of climate trends and variability, but also as inputs to hydrological and ecological models and for model validation, characterization of extreme events, and flood and drought forecasting.

The analysis provides an estimate for the feedback terms that could be used for model validation studies.

Additional known locales where this species has been collected in New York City and its northern and eastern suburbs, southern Connecticut, and isolated southern New England areas were not included in model development, but were useful for model validation.

It is worth noticing that NASA has been the leader in the establishment of many Management, Quality and Design / Technical Specifications, Rules or Standards, including for models validation, which have been derived in many other countries or other scientific domains.

Not exact matches

After an extensive content validation process, including expert panel review by all Steering Committee members and all work group members, the final instrument included 130 core items that collected information on demographics, access to maternity care, preferences for model of care, maternal and newborn outcomes, knowledge of midwifery care, and experience of care including the process of decision - making.

Using the calibrated models, the researchers then applied NIRS to a random mix of mosquitoes and checked the results against validation tests using mosquito extracts for molecular detection of strain - specific Wolbachia DNA to determine accuracy.

Any results that are reported to constitute a blinded, independent validation of a statistical model (or mathematical classifier or predictor) must be accompanied by a detailed explanation that includes: 1) specification of the exact «locked down» form of the model, including all data processing steps, algorithm for calculating the model output, and any cutpoints that might be applied to the model output for final classification, 2) date on which the model or predictor was fully locked down in exactly the form described, 3) name of the individual (s) who maintained the blinded data and oversaw the evaluation (e.g., honest broker), 4) statement of assurance that no modifications, additions, or exclusion were made to the validation data set from the point at which the model was locked down and that neither the validation data nor any subset of it had ever been used to assess or refine the model being tested

They also used tenfold cross validation to train the models for responsiveness, and then tested these on the validation samples as well.

The researchers also tested their prediction models on the validation set, and this resulted in ROC (receiver operating characteristic) plot points with an AUC (area under the curve) of 91.6 percent for general responsiveness, 89.7 percent for TNFi response and 85.7 percent for rituximab response.

They used 70 percent of the samples to develop response prediction models, and reserved 30 percent for validation.

Gorlov says the empirical model can be used to select SNPs for validation and prioritization.

Researchers developed and validated the nomograms for OS and PFS using a derivation cohort and the models were applied to a validation cohort.

[2] Lipid method Chunxiu Hu et al., RPLC - Ion - Trap - FTMS Method for Lipid Profiling of Plasma: Method Validation and Application to p53 Mutant Mouse Model.

IDMIT will contribute 1) To the development and validation of assays based on flow cytometry and mass cytometry for the evaluation of immune responses in humans and animal models; these tools will be particularly relevant for the identification of signatures of vaccine efficacy; 2) To the animal model platform, in particularly by providing access to NHP models and to new technologies for in vivo imaging infections and host responses; 3) To networking activities, in particular by organising a workshop on in vivo imaging.

Validation and testing of this model for a number of research questions related to treatment of stress urinary incontinence are under way.

For each IAT, the authors examined their technological type, application, target population, model... of development, and evidence of clinical validation.

Our goal is to help scientists who want to use this technology for gene editing by summarizing current advances on many technical aspects, from the RNA guide optimized design to the genotyping analysis and the validation of the newly generated models.

The Ospedale San Raffaele Mouse Clinic (OMC) is the follow - up and consolidation of a Regione Lombardia - funded project (EMDM), which aimed at the establishment and implementation of a large, dedicated facility (the European Mouse Disease Models Center) whose goal is the development and functional assessment of mouse disease models, both for the dissection of the underlying pathogenic mechanisms and for the screening and validation of innovative diagnostic and therapeutic proceModels Center) whose goal is the development and functional assessment of mouse disease models, both for the dissection of the underlying pathogenic mechanisms and for the screening and validation of innovative diagnostic and therapeutic procemodels, both for the dissection of the underlying pathogenic mechanisms and for the screening and validation of innovative diagnostic and therapeutic procedures.

In addition, the E3SM project benefits from - DOE programmatic collaborations including the Exascale Computing Project (ECP) and programs in Scientific Discovery Through Advanced Computing (SciDAC), Climate Model Development and Validation (CMDV), Atmospheric Radiation Measurement (ARM), Program for Climate Model Diagnosis and Intercomparison (PCMDI), International Land Model Benchmarking Project (iLAMB), Community Earth System Model Community Earth System Model (CESM) and Next Generation Ecosystem Experiments (NGEE) for the Arctic and the Tropics.

Our goal in using this multifaceted model was two-fold 1) to confirm and further characterize the distinct behavioral traits in animals most susceptible to social stress after going through the 10 - day social defeat paradigm compared to undefeated control animals; 2) to provide pharmacological validation for this model using standard antidepressant medications such as fluoxetine and imipramine.

For a given tissue, we perform 3 - repeat -5-fold cross validation with the samples corresponding to the individuals of the training block in order to select the best model, and we generate the predictions over the unseen test set using this model.

All data for training the QSAR models were obtained from PubChem and curated according to associated validation and counter screens.

The ICS is a large - scale facility open to the community that ensures the generation of mouse models à la carte, the validation of genetic models, the expansion and preservation and distribution of models with the housing department, and offers in its phenotyping department a series of standardized functional analysis of mouse models that can be performed in a comprehensive pipeline or on demand, as well as for more specialized studies, that cover the major functions and key physiological systems.

Once each tissue model is fitted on the training set with 3 - repeat -5-fold cross validation, we calculate the p - value of the F - test (Supplementary Fig. 28), R2 and slope (not shown) for the regression of the predicted tissue PMI in the test set versus the real tissue PMI.

Use of genetically modified rodents for gene validation - New approaches for time saving and models of higher relevancy

The phenotyping platforms of PHENOMIN - ICS area, adapted to study genetically modified mouse models, can also be used for preclinical studies, including the validation of therapeutic targets, as well as pharmaceutical and toxicological studies in mice.

This toolbox can be used for a wide variety of applications including drug discrimination, validation of experimental medicine models and patient stratification.

The role of new genetic pathways in cancer biochemistry (the genome mutation profiles), the identification of the key targets and their validation, as well as utilization of new knock - out or knock - in animal models for such studies are among topics that will be discussed.

The development and validation of new risk scores with sex - specific weighting of risk factors could be a promising tool for future prediction models.

To this end, for each cohort (pre-mortem and postmortem), we partitioned the data into training and testing datasets, fitted the model on the training data with 3 - repeat -5-fold cross validation, performed the predictions on the test set and then obtained the regression statistics of real vs. predicted Blood PMI.

This exciting partnership offers our European clients a complete integrated solution for mouse and rat models, from creation to validation.

I proposed an invited session for the 2016 ASHG meeting because I believe that inherited retinal diseases offer several key advantages as a model system for gene discovery, functional validation, genetic counseling, and individualized treatment.

Based on their success to date in models of glaucoma, the researchers are making significant steps toward moving into human testing and validation of a biomarker for clinical use.

Reactor enables evaluation of reactive materials for solar ‑ thermochemical hydrogen production under real ‑ world conditions, and provides a learning platform for up - scaling technology as well as model validation.

Modeling Kepler transit light curves as false positives: Rejection of blend scenarios for Kepler - 9, and validation of Kepler - 9d, a super-Earth-size planet in a multiple system

The validation of the procedure was done on the data extracted from simulated roots (see Appendix Text: Section S1.D) and is shown in Appendix Figs S5 — S7 for each model.

This environment, designated the Virtual Environment for Reactor Applications (VERA), incorporates science - based models, state - of - the - art numerical methods, modern computational science and engineering practices, and uncertainty quantification (UQ) and validation against data from operating pressurized water reactors (PWRs), single - effect experiments, and integral tests.

To inform further DST development for cell therapies, we examined existing process systems along a number of dimensions: e.g., cell type, process scale, modeling techniques used, and degree of validation.

The need for a systematic approach to tractography validation and for a framework to perform statistical model testing in individual brains has been claimed (Pestilli Nature: Scientific Data 2015).

Using high throughput robotic platforms and 3D multicellular tumor spheroid cell culture models for high throughput RNAI and drug screens for target identification and validation

Godwin's findings are a validation of the MDI Biological Laboratory's unique research approach, which is focused on studying regeneration in a diverse range of animal models with the goal of gaining insight into how to trigger dormant genetic pathways for regeneration in humans.

He has developed laboratory and animal models of the tumor in its microenvironment, which have allowed for both identification of novel targets and validation of novel targeted therapies.

Therefore, transcriptomics, metabolomics, proteomics and high - throughput techniques are used to collect quantitative data for the construction and validation of models.

But what I found most helpful was it's approach on how to sort through your own personal emotional baggage, boost self - esteem through personal validation, map out both good and bad patterns in finding someone, and creating a written model for not just your ideal partner, but the ideal you.

Currently, he is working on contrasting between state growth model approaches and developing new gap trend and growth metrics for cross-test comparison and validation.

«New Jersey had a rigorous process for vetting teacher evaluation models requiring a strong research - base and validation studies,» said Michael Toth, CEO, Learning Sciences International.

• A common language of instruction • Lists of possible evidences for each element • Identical scales: «not using» to «innovating» • An extensive research base for the Marzano models • Validation from use in other schools • A focus on common learning goals

We will simply point out that the conception of teaching effectiveness and teacher training has expanded to include consideration of the context in which teachers work (i.e., the context is also a target for the interventions, not just the teacher), the refinement of teacher training into trainer of trainer models with strict control over and monitoring of performance, ongoing data gathering for program validation and program improvement purposes, and the protection of proprietary rights to the materials and processes used.

He is a leader and a co-founder of Diplomas Now, an evidence based school transformation model for high needs middle and high schools which combines whole school reform with enhance student supports guided by an early warning system and winner of a federal Investing in Innovation (I3) validation grant which is currently being implemented in forty schools across twelve school districts.