Sentences with phrase «for mutations in this specific gene»

Not exact matches

Scientists have figured out the specific gene mutation responsible for red hair — and why it's more common in beards than on heads.

Scientists had been searching in vain for such a gene since 1994 when Rockefeller University scientist Jeffery Friedman found that lab mice with a specific genetic mutation fail to produce leptin and as a result have uncontrollable appetites, and become huge.

For example, changes in certain genes could indicate that his cancer was more likely to respond to a particular drug, while other mutations might predict little benefit from a specific therapy.

Anne Goriely of the University of Oxford and her colleagues took tumour cells from men with benign testicular tumours and looked for specific mutations in the FGFR3 and HRAS genes.

We report here 13 mutations in the fused in sarcoma / translated in liposarcoma (FUS / TLS) gene on chromosome 16 that were specific for familial ALS.

In fact, there are two specific mechanisms for activation of BRAF implicated in PA formation: by fusion of the gene with nearby gene KIAA1549 (K: B fusion) or by point mutations of the BRAF gene itselIn fact, there are two specific mechanisms for activation of BRAF implicated in PA formation: by fusion of the gene with nearby gene KIAA1549 (K: B fusion) or by point mutations of the BRAF gene itselin PA formation: by fusion of the gene with nearby gene KIAA1549 (K: B fusion) or by point mutations of the BRAF gene itself.

For example, drugs that target a specific BRAF gene mutation commonly found in melanoma shrink tumors in about half of patients with the mutation.

Using biopsies of the patients» tumors collected before the start of treatment and at the time patients developed resistance, the researchers performed large - scale genomic analyses to search for mutations specific to the cancer cells in all of each patient's 20,000 genes.

It has been shown previously that in Escherichia coli the mfd (mutation frequency decline) gene is necessary for strand - specific repair.

The Yale - led study performed whole exome sequencing ¬ — a technique for sequencing all the expressed genes in a genome ¬ — on TNBC tumors to identify mutations in specific genes or pathways that may indicate response or resistance to the standard of care, which is anthracycline / taxane (ACT) chemotherapy.

She found, for example, that by using a technique called the polymerase chain reaction to amplify genes, she could detect mutations or rearrangements in cancer - specific genes in irradiated tissue that had turned cancerous.

Thus, neural derivatives of disease - specific human pluripotent stem cells constitute a relevant biological resource for exploring the impact of adult - onset HD mutations of the HTT gene on the division of neural progenitors, with potential applications in HD drug discovery targeting HTT - dynein - p150Glued complex interactions.

«Originally, we wanted to establish a disease model for FOP that might help us understand how specific gene mutations affect bone formation,» said first author Yohei Hayashi, PhD, a former postdoctoral scholar in Yamanaka's laboratory.

Monitoring parasite populations for a specific genetic background — in this case, a fixed set of four well - defined mutations in the fd, arps10, mdr2, and crt genes — could allow researchers to assess the likelihood of new resistance - causing mutations emerging in different locations, helping to target high - risk regions even before resistant parasites take hold.

A specific codon (34) in U2AF1 harbored missense mutations in multiple AML tumors, suggesting a gain - of - function for the splicing factor encoded by that gene.

Overlap — Finally, successful drug targets significantly overlap with disease genes — those in which a mutation can cause a specific disease, such as cystic fibrosis — and with essential genes, that are required for normal development.

As a reagent manufacturer, we offer a comprehensive selection of gel, capillary, and next - generation sequencing PCR assays for gene rearrangement, chromosome translocation, and gene mutation detection as analyte specific reagents (United States), research use only, or CE - marked in vitro diagnostics to laboratories (outside of North America).

«We saw hundreds of changes in genes in cancer cells that had not been identified before, and for each of these, HHMI research associate Alberto Bardelli had to perform comparisons with the normal tissues of the same patient, to see if the mutation was specific to the cancer,» he said.

The reason for all the types of mutations is variations in the specific genes passed on from each parent.

In addition, True Health offers the ability for clinicians to test individual, single - site genes as needed for patients with specific mutations known in the familIn addition, True Health offers the ability for clinicians to test individual, single - site genes as needed for patients with specific mutations known in the familin the family.

For example, a mutation test detects one specific mutation in one specific gene.

In fact, there's a test available now for a specific gene mutation in Maine Coones and ragdollIn fact, there's a test available now for a specific gene mutation in Maine Coones and ragdollin Maine Coones and ragdolls.

For example, the prcd - PRA DNA test detects one specific mutation in the prcd gene and the XL - PRA test detects a specific mutation in a different gene.

Modeled on our PRA research program, these projects are aimed at identifying the genes and mutations responsible for specific cataracts found in certain breeds.