The next big clue came when Mignot of Stanford University tracked down a gene
for narcolepsy in dogs and discovered it caused a mutation in a receptor for hypocretin, a neuropeptide involved in prodding the central nervous system awake and maintaining alertness and good muscle tone.
The investors are frustrated that shares in Jazz, a $ 9 billion pharmaceutical company
known for its narcolepsy drug Xyrem, have remained essentially flat over the past year.
Julie has received tons of press and is the
spokesperson for narcolepsy, a neurological auto - immune sleep disorder that affects 200,000 to 250,000 Americans.
Similar mutations, it turned out, appear in both Doberman pinschers and Labrador retrievers
bred for narcolepsy.
Her intuition may be correct and could have a physiological explanation, says Emmanuel Mignot, a Howard Hughes Medical Institute investigator and director of the
Center for Narcolepsy at Stanford University.
«Mignot told Science that while attempting to develop a diagnostic
test for narcolepsy based on the assay, «my lab could not make the ELISpot test work.»»
These studies have been questioned as the genetic variant
required for narcolepsy protects against autoimmune type 1 diabetes.
Exploiting methods that he developed in his hunt for the gene
responsible for narcolepsy, Mignot is now in hot pursuit of a KLS gene.
And finding an immunological
marker for narcolepsy is important for reasons beyond just proving that it's an autoimmune disease.
Modafinil, a drug
prescribed for narcolepsy and attention - deficit hyperactivity disorder (ADHD)-- and used illicitly by an increasing number of people to enhance cognitive performance — could be addictive, according to a small study of 10 people who underwent high - tech brain scans.
In 2013, before the «Obamacare» exchanges launched, he paid $ 483 a month in premiums, plus $ 1,203 a
month for narcolepsy medication and $ 200 for cholesterol medicine until he reached a $ 5,000 deductible.
In December, Outi Vaarala of the University of Helsinki and her colleagues had reported that Pandemrix contained a much higher level of nucleoprotein than a GSK vaccine called Arepanrix, which was associated with a much smaller
risk for narcolepsy.
It sounds like Bandit may have narcolepsy; it can occur when a dog gets over excited they just collapse to the floor and then get up like nothing happened; it can be misdiagnosed as a seizure, but seizures are usually violent episodes with shaking, incontinence etc... There is no
treatment for narcolepsy, but it is harmless and doesn't progress in severity.
A review of the autoimmune
hypothesis for narcolepsy, and the role that H1N1 vaccination and live - virus infection may have played.
This idea inspired Eric Konofal at Robert - Debré Hospital in Paris to try using a drug
for narcolepsy and excessive daytime sleepiness to treat ADHD.