The study contributes to our fundamental understanding of how bacteria adapt and survive under adverse conditions and provides clues about key processes that could be targeted in the
search for new antibiotics.
«We are now using this method to
look for new antibiotics from unique collections of microbes to find those that are active against antibiotic resistant bacteria,» she said.
This growing public health threat has motivated scientists to
look for new antibiotics and alternative treatments to beat infections.
As the fight against drug - resistant infections continues, University of Leeds scientists are looking back at previously discarded chemical compounds, to see if any could be
developed for new antibiotics.
«Our initial discovery allowed us to perform the equivalent of an autopsy on bacterial cells and is changing the way industry searches
for new antibiotics from collections of pure chemicals,» said Kit Pogliano, a professor of biology at UC San Diego who headed the research team.
Imposing a 50 % tax on antibiotics for food animals could decrease global consumption by more than 30 %, and at the same time generate revenues from $ 1.7 to 4.6 billion, which could be invested into
research for new antibiotics or improvements to farm hygiene.
You can see that the search
for new antibiotics occurs down at the enzyme level, hunting for differences between the enzymes in human and bacterial cells that can be exploited to kill bacteria without affecting human cells.
Structure of bacterial RNA polymerase, showing the binding
sites for the new antibiotic pseudouridimycin (PUM) and the current antibacterial drug rifampin (Rif).
Population expansion may be a major driver in the evolution of cooperation, with
implications for new antibiotics, cancer treatments and perhaps even human behavior.
Scientists at the University of Sussex in the UK have unraveled a key process in the bacterium that causes tuberculosis (TB), potentially paving the
way for new antibiotics to fight the disease.
6 - dependent protein, potentially opening
avenues for new antibiotics and drugs to battle diseases such as drug - resistant tuberculosis, malaria and diabetes.
Price also advocated streamlining the Food and Drug Administration's approval
processes for new antibiotics and medical devices, and giving scientists more discretion in how federal research dollars are allocated.
In the non-stop fight against infectious agents, many researchers have foregone
searching for new antibiotics and instead have turned to older antibiotics that never reached the clinic for one reason or another.
«At the national organization level there's a clear recognition of the need
for new antibiotics.»
Supporting Dr O'Neill's work, Dr Jonathan Pearce, Head of Infections and Immunity at the Medical Research Council, said: «There is an urgent need to discover new ways to fight AMR and the scientific community is leaving no stone unturned in its search
for new antibiotics.
«While the infectious - disease community was crying out
for new antibiotics, the FDA seemed to be going in the opposite direction.»
The study has applications regarding the search
for new antibiotics that can be used in humans.
«Once you find metabolites and want to analyze
them for new antibiotics or new pathways, you need the genome information to identify the enzymes and clone the genes.»
The need
for new antibiotics is there and if Cubist can continue to identify growth markets and develop treatments for them, it can have sustained success beyond these drugs.