Ottawa, ON About Blog DNA Genotek develops products that optimize ease of collection and provide superior samples and proven performance for those requiring high - quality biological samples
for nucleic acid testing.
NEUROLOGICAL HEALTH: Vitamin B12 is also required
for nucleic acid (DNA) synthesis, methionine synthesis from cysteine, and normal myelin synthesis in the nervous system.
The two cell types are important to a broad range of organ systems in the body and play active roles in diseases that could be targets
for nucleic acid therapies.
That is, they depend on the host cell for the raw materials and energy necessary
for nucleic acid synthesis, protein synthesis, processing and transport, and all other biochemical activities that allow the virus to multiply and spread.
However the team from the Krebs Institute
for Nucleic Acids at the University of Sheffield found that the key to preventing resistance to a common class of chemotherapy used to treat breast and colon cancer is to change the speed in which the cancer cells repair damage to their DNA that is introduced by chemotherapy.
Not exact matches
Says Roberts: «He quickly figured out that if Illumina was successful, it would need more than the world's supply of oligonucleotides» — the short snippets of
nucleic acid that are designed to pair up with specific genetic sequences, and which are critical
for DNA or RNA analysis.
A preference
for atomicity (explanation in terms of amino and
nucleic acids) prescribes the method
for molecular biology; and a persistent materialism hovers over the essentially anti- mechanistic physics of this century.
it is there
for very easy to expect that 3.5 - 4 billion years ago there were pools of water full of self replicating
nucleic acids.
For example, after the macromolecules of amino
acids or
nucleic acids have become sufficiently abundant, the possibility of living cells becomes a relevant new form of ordered novelty in the world's advance.
Healthy fats like alpha - linolenic
acid, oleic
acid, a balanced supply of Omega - 3 and Omega - 6 fatty
acids;
Nucleic acids for building DNA and RNA;
The spherical structure of the SNAs is the ideal architecture
for delivering
nucleic acids into cells
for gene regulation, Mirkin said.
«It is the only known
nucleic acid platform
for treating such ailments and constitutes a new pipeline of therapeutics to address a broad swath of debilitating health conditions.»
The tests use the so - called polymerase chain reaction (PCR), a conventional method
for detecting
nucleic acid.
Over the past decade, healthcare providers have been able to expand screening programs
for chlamydia thanks to the development of a highly sensitive method known as
nucleic acid amplification testing (NAAT).
Together with his principal investigator (PI), he had realized the commercial potential of modifying nanoparticles with
nucleic acids to create targeted, personalized medicines
for a myriad of diseases.
«Our research supports the development of targeted
nucleic acid delivery platforms
for therapeutics
for autoimmune diseases and cancer,» says Prof. Peer.
In 2009, a team led by Svante Pääbo of the Max Planck Institute
for Evolutionary Anthropology in Leipzig, Germany, uncovered evidence of the process in Neanderthal and mammoth DNA (
Nucleic Acids Research, DOI: 10.1093 / nar / gkp1163).
His suspicionswas confirmed: the children had an identical defect — a missing single
nucleic acid, called guanine — in the gene coding
for leptin.
An HPV test, in which doctors test a cervicovaginal specimen
for the presence of the
nucleic acids of carcinogenic types of HPV, is more sensitive than the Pap test (a microscopic examination of exfoliated cells)
for detection of precancers.
They work on microarray - based gene sensors
for analyzing
nucleic acids quickly and cheaply.
It was not until the polymerase chain reaction technique
for amplifying
nucleic acids was developed in the late - 1980s that it became possible to do anything with the tiny and fragmentary biochemical evidence from insects embedded in amber.
While James Watson and Francis Crick are considered the godfathers of DNA, Hoerr says, Miescher never received the credit he deserved
for isolating and analyzing
nucleic acids from pus cells.
For tumors to grow and spread, cancer cells must make larger than normal amounts of
nucleic acids and protein, so they can replicate themselves.
The scientists at the Institute
for Research in Biomedicine (IRB Barcelona) describe the uses of the program in an article published in the journal
Nucleic Acids Research, in which they explain that ChroGPS is the answer to a problem that has been dragging on
for the last ten years.
The article in the journal Molecular Therapy —
Nucleic Acids titled «As Technologies
for Nucleotide Therapeutics Mature, Products Emerge» describes the analysis of more than 60,000 research publications related to oligonucleotide therapies.
Now, Wyss Institute researchers led by Church have developed a new suite of such sensors, reported in
Nucleic Acids Research journal, that not only increase the number of cellular «switches and levers» that scientists can use
for complex genetic re-programming, but also respond to valuable products such as renewable plastics or costly pharmaceuticals and give microbes a voice to report on their own efficiency in making these products.
And a new prototype device can display a fluorescent letter in the presence of
nucleic acid sequences from the Ebola virus or the closely - related Marburg virus: «E»
for Ebola or «M»
for Marburg.
For these tests, doctors isolate and amplify viral
nucleic acid in samples from an infected patient.
Attendees at the astrobiology meeting in Arizona showcased an assortment of high - tech devices
for next - generation exploration, ranging from microfluidic «life analyzers» and integrated
nucleic acid extractors
for studying «Martian metagenomics» to exquisitely sensitive, miniaturized organic chemistry labs
for spotting tantalizing carbon compounds and minerals at microscopic scales.
Department of
Nucleic Acids Research, Genetic Engineering and Biotechnology Research Institute, City
for Scientific Research and Technology Applications, Borg El - Arab, Post Office Box 21934, Alexandria, Egypt.
Two projects will be done jointly with the Karolinska Institute in Stockholm: Molecular biologist David Baillie of Simon Fraser University in Burnaby, British Columbia, was awarded $ 6.73 million to study protein function in the soil nematode Caenorhabditis elegans, and microbiologist Sherif Abou Elela of the University of Sherbrooke, Quebec, received $ 3.75 million to test modified
nucleic acid technologies
for determining gene function.
MicroRNAs are short bits of
nucleic acid — the material of DNA and RNA — that can bind to messenger RNAs that code
for protein because they have a complementary sequence of A, U, C and G.
MicroRNAs are very short bits of
nucleic acid — the material of DNA and RNA — that can bind to messenger RNAs that code
for protein.
BioGene is at the forefront of innovative, UltraRapid Molecular Biology solutions
for rapid detection of
nucleic acids and this research has led to a very exciting platform technology, and one that we are looking to develop further.»
To try to block elastase, biochemist Drew Smith of NeXstar Pharmaceuticals in Boulder, Colorado, earlier this year synthesized a
nucleic acid sequence called an aptamer, which is designed
for its shape.
Researchers have argued
for decades whether these anchors have their own «genome,» and if so, whether its
nucleic acid sequence is DNA or RNA.
He won two Nobel Prizes
for chemistry, but we claim him
for molecular biology because the methods he developed
for sequencing proteins and
nucleic acids provide the basis
for much of what we do today.
Joint winner of the 1980 chemistry prize with Walter Gilbert
for his «contributions concerning the determination of base sequences in
nucleic acids» and winner of the 1958 chemistry prize «
for his work on the structure of proteins, especially that of insulin.»
Winner of the 1982 chemistry prize «
for his development of crystallographic electron microscopy and his structural elucidation of biologically important
nucleic acid - protein complexes.»
Joint winners of the 1962 physiology or medicine prize with Maurice Wilkins «
for their discoveries concerning the molecular structure of
nucleic acids and its significance
for information transfer in living material.»
Researchers at Stockholm University and Science
for Life Laboratory have developed a new computer algorithm
for analysing gene function called BinoX, which was e-published in
Nucleic Acids Research on September 22 (Ogris et al., 2016a).
Scientists are also breaking ground with
nucleic acid platforms that have the potential to deliver cancer vaccines,
for neoantigens and other targets.
ANA (amyloid
nucleic acid) consists of
nucleic acids attached to amyloid proteins, infamous
for their role in Alzheimer's disease.
Intrigued by the ability of certain polymers to mop up DNA and RNA
for gene transfer, Sullenger and colleagues tested the idea that these chemical compounds might also be effective targeting such
nucleic acids as they arise in cell death.
The same thing had previously been done
for threose
nucleic acid (TNA).
For this reason, the US Food and Drug Administration has recommended screening of donor blood using a
nucleic acid test (NAT).
Life on Earth originated in an intimate partnership between the
nucleic acids (genetic instructions
for all organisms) and small proteins called peptides, according to two new papers from biochemists and biologists at the University of North Carolina at Chapel Hill and the University of Auckland.
Proteins, fatty
acids, and
nucleic acids are essential factors
for cell survival using glutamine metabolism.
Church says base editing should be evaluated «case - by - case»
for whether it offers advantages over CRISPR and other technologies that alter
nucleic acids.
Mirkin is director of the research group that invented the chemistry
for conjugating DNA and nanoparticles and a pioneer of the concept of programmable colloidal crystallization with
nucleic acids.