Sentences with phrase «for nucleosome»

Not exact matches

In this way the binding of the DNA to the corresponding nucleosome is changed so that the DNA for example becomes accessible for transcription enzymes and activates a particular gene.

The authors conclude that this newly discovered allosteric mechanism «suggests that allosteric modulation in nucleosomes may have biological relevance and potential for therapeutic interventions.»

The dynamics of nucleosome formation and positioning in promoters may, for example, help to understand why some genes are highly expressed, such as those involved in normal or malignant growth, while others, such as stress - induced genes, are only rarely expressed under normal conditions.

In 2012, for example, Willerslev's lab published an analysis of proteins, which are generally longer lived postmortem than genetic material, of 43,000 - year - old woolly mammoth bones.16 And last year, Willerslev, Orlando, and colleagues published a genome - wide nucleosome map and survey of cytosine methylation levels in the DNA they pulled from the 4,000 - year - old hair shafts of a Paleo - Eskimo, effectively launching the field of ancient epigenetics.17 Also last year, Pääbo's group at the Max Planck Institute for Evolutionary Anthropology published the first full DNA methylation maps of the Neanderthal and Denisovan genomes.18 «For the first time we'll be able to address what is the role of epigenomics and epigenetics in evolution,» Willerslev safor example, Willerslev's lab published an analysis of proteins, which are generally longer lived postmortem than genetic material, of 43,000 - year - old woolly mammoth bones.16 And last year, Willerslev, Orlando, and colleagues published a genome - wide nucleosome map and survey of cytosine methylation levels in the DNA they pulled from the 4,000 - year - old hair shafts of a Paleo - Eskimo, effectively launching the field of ancient epigenetics.17 Also last year, Pääbo's group at the Max Planck Institute for Evolutionary Anthropology published the first full DNA methylation maps of the Neanderthal and Denisovan genomes.18 «For the first time we'll be able to address what is the role of epigenomics and epigenetics in evolution,» Willerslev safor Evolutionary Anthropology published the first full DNA methylation maps of the Neanderthal and Denisovan genomes.18 «For the first time we'll be able to address what is the role of epigenomics and epigenetics in evolution,» Willerslev saFor the first time we'll be able to address what is the role of epigenomics and epigenetics in evolution,» Willerslev says.

Pozhitkov et al. 29 described an increased expression of epigenetic regulatory genes, hypothesizing that the activation of these genes reveals the nucleosomes and allows for the later transcription of developmental genes that have no early expression.

Gene ontology analysis of the genes affected across several tissues (Supplementary Fig. 8) shows enrichment for genes in the extracellular region and genes involved in nucleosome and chromatin assembly and in protein — DNA complexes.

The evidence for this comes from observing 30 nm and 120 nm wide fibres formed by DNA and nucleosomes purified from cells.

The DNase I data exploits a structural feature of regulatory DNA that's been known for decades: the binding of sequence - specific transcriptional regulators in place of nucleosomes creates DNase I hypersensitive sites, or DHSs.

The four histones create a new nucleosome spool for that section of DNA.

The Cac2 subunit is essential for productive histone binding and nucleosome assembly in CAF - 1.