Not exact matches
The compound, which is widely prescribed
for breast cancer, is known to block
oestrogen receptors on many cancer cells, so inhibiting their growth.
«This means that tamoxifen, which is probably the best therapy
for breast cancer available, is not working solely through blocking the
oestrogen receptors, which everyone thought it did.
One third of the target genes
for which they had patient data - 32 out of 97 - were also linked to survival in women with
oestrogen receptor - positive breast cancer, suggesting they play an important role in the disease.
Previous large - scale genetics studies have implicated 14 of the 110 genes as playing a role in breast cancer risk, such as the
oestrogen receptor gene ESR1, showing that Capture Hi - C is an effective tool
for picking up risk genes.
My translational research has focused on trying to find better ways to estimate recurrence risk in patients diagnosed with
oestrogen -
receptor positive early breast cancer, with the ultimate aim to better personalise our therapies
for those patients who have the most to gain from them.
A role
for the androgen metabolite, 5alpha - androstane - 3beta, 17 beta - diol, in modulating
oestrogen receptor beta - mediated regulation of hormonal stress reactivity..
The
oestrogens that negatively impact on our body either settle in the
receptor sites reserved
for natural
oestrogen production, or can have very damaging effects on the body as the liver attempts to detoxify them.
These are environmental toxins that are absorbed in the blood stream and take up residence in the
receptor sites reserved
for normal
oestrogen activity.