Sentences with phrase «for old mice»

The problems are many: Young blood didn't do much for old mice in other studies.

Of 69 rodent pairs, 11 did die of «parabiotic disease,» essentially a form of tissue rejection, but in the other pairs, the effects were noticeably positive — although only for the older mice.

Not exact matches

Old input methods such as mice and keyboards are likely going to contribute to poor experiences, said Chu Hanjin, director of content alliances and solutions for AMD's Radeon Technology Group.

Don't forget that Cech has won PL & CL trophies in his time at Chelsea and there was no way that he was going to let some of his old buddies take the mick out of him for lifting and celebrating some Mickey Mouse cup??

As for me, when I get to that voting booth I may have to fall back on that old reliable write in favorite, Mickey Mouse.

«To do so, we simply inserted earplugs in the ears of 10 - day - old mice and left them in position for 10 more days.

Additional experiments showed that the vaccine was durable, effective for at least 6 months, and that it worked well in older mice.

For this procedure, a smaller, younger mouse is paired with a larger, older, and more aggressive mouse.

After 18 - month - old mice were treated with NMN for two months, their capillary density was restored to levels typically seen in young mice, and they experienced a 56 to 80 percent improvement in endurance.

Additionally, the researchers report online today in Cell, old mice injected with this protein for 30 days developed younger, stronger heart tissue.

These mice survived about 600 days after exposure to infectious prions — well into old age for a mouse.

The researchers extracted mammary buds, the early developing form of the mammary gland, from 14 - day - old mouse embryos, which is a critical time for mammary development in rodents, according to Speroni.

A preclinical study in mice published by Cell Press January 16th in the journal Cell reveals that drugs known as histone deacetylase inhibitors (HDACis) can enhance the brain's ability to permanently replace old traumatic memories with new memories, opening promising avenues for the treatment of posttraumatic stress disorder (PTSD) and other anxiety disorders.

Representative images of P - PERK (green) in B - cells (red) immunostained for insulin in young undisturbed (YC), young SD (YSD), old undisturbed (OC) and old sleep deprived (OSD) mice.

ARTIST IN RODENTS African striped mice (one shown munching on a thorn tree) evolved a new trick for an old protein.

«Older wombs linked to complications in pregnant mice: Increased risk of pregnancy complications for older mothers might be linked to poor placenta growth.&rOlder wombs linked to complications in pregnant mice: Increased risk of pregnancy complications for older mothers might be linked to poor placenta growth.&rolder mothers might be linked to poor placenta growth.»

In the first group, old mice were trained three days / week for eight weeks.

This artificial joining of two separate animals, known as parabiosis, was a staple of physiology experiments for over a century before Irina Conboy got the idea to pair an old mouse with a young one.

The endurance of the mice also improved, enabling them to spend an average of 57 minutes on a treadmill compared with 35 minutes for untreated old mice.

Besides the reduced numbers of helper T cells in the DLNs, the researchers also found that the lymph node environment in older mice contained lower levels of immune stimulators (so - called chemokines) and therefore was less capable of attracting other immune cells necessary for germinal center formation.

In the brain study, the researchers injected 15 - month - old mice — which is just over half their natural life span — with GDF11 daily for a month.

As these studies were being done, Malaspina asked Jay Gingrich, a psychiatrist and neuroscientist at Columbia who works with mice, whether he could look for the same effect in the offspring of older mice.

Specifically, they looked at eIF2alpha phosphorylation and the regulation of protein synthesis in the mice's hippocampus region — the part of the brain responsible for the retrieval of old memories and the encoding of new ones.

When the research team gave old mice — the equivalent of 70 - to 80 - year - old humans — water containing an antioxidant known as MitoQ for four weeks, their arteries functioned as well as the arteries of mice with an equivalent human age of just 25 to 35 years.

By 18 months — old age for a mouse — the mice from generations 3 through 6 were going grey and balding.

The researchers bred mice deficient for the protein — called placental growth factor (PlGF)-- and broke their tibias under anesthesia when they were 11 weeks old.

Islets isolated from 3 wk - old Tg - hIAPP mice were treated with different concentrations of synthetic IAPP - aggregated seeds for 10 d.

Tapio, for example, is about to start work on paraffin - embedded heart tissue from irradiated mice from the old Russian and US studies.

Isolated islets from 3 - wk - old Tg - hIAPP, which do not exhibit IAPP aggregates at that age (Janson et al., 1996), were cultured in the presence of 1 % or 0.1 % islets extracts from old Tg or WT mice for 7 d under standard conditions, including a glucose concentration of 11 mM in the medium to reduce glucotoxicity and spontaneous aggregation of the protein (Zraika et al., 2007).

8 - 10 wk old female and male mice are provided ad lib access to ethanol - or pair - fed diets up to 5 % ethanol for 10 days.

Male or female (5 - 6 wks old) wild type and genetically modified mice (as required for individual investigator's protocols) will be fed a high fat high sucrose diet (from Research Diets ranging in fat from 45 - 58 % of calories as fat, 26 - 39 % carbohydrate (sucrose) and 16 % protein or control diets (10 % fat, 73 % carbohydrate, 16.4 % protein or rodent chow) for up to 16 weeks.

To appreciate the difference, consider that the old way involves introducing DNA into mouse embryonic stem cells, and then selecting for the rare cells that take up and incorporate the DNA in the right way.

For a mouse, «elderly» means 18 months old.

Lloyd Old, Thierry Boon, and colleagues develop the TNF release assay for mouse systems in which release of TNF by T cells could be used to assess specific T cell recognition, facilitating the cloning of human tumor antigens.

One - month - old wild - type (n = 6) and p21 - null (n = 18) female mice were irradiated (+ IR) weekly for 4 weeks with 1.75 Gy.

Gene therapy rescues cone structure and function in the 3 - month - old rd12 mouse: a model for midcourse RPE65 leber congenital amaurosis.

For γ - radiation tumorigenesis, 1 - month - old mice were irradiated weekly for 4 weeks with a 1.75 - Gy dose from a 137Cs source (MARK 1 - 30 Irradiator; Shepherd & Associates) at a rate of 1.14 Gy / mFor γ - radiation tumorigenesis, 1 - month - old mice were irradiated weekly for 4 weeks with a 1.75 - Gy dose from a 137Cs source (MARK 1 - 30 Irradiator; Shepherd & Associates) at a rate of 1.14 Gy / mfor 4 weeks with a 1.75 - Gy dose from a 137Cs source (MARK 1 - 30 Irradiator; Shepherd & Associates) at a rate of 1.14 Gy / min.

As a control, irradiation of wild - type mice resulted in 100 % mortality after a period of 9 months after irradiation, when the mice were 11 months old (Fig. 3 ⇓ shows the survival curve of the females alone for the purpose of simplifying the discussion below); and mortality was mainly attributable to the development of T - cell lymphomas (Table 3) ⇓.

Administered in the food of 20 - month - old genetically engineered mice, at a stage when Alzheimer's pathology is advanced, J147 rescued severe memory loss, reduced soluble levels of amyloid, and increased neurotrophic factors essential for memory, after only three months of treatment.

Four - to six - week - old female mice were used for tumor injections.

When administered in food at a stage when pathology is advanced in 20 - month - old transgenic AD mice, J147 rescued the severe loss of cognitive function, reduced soluble levels of Aβ and increased neurotrophic factors essential for memory.

Based upon activity in multiple CNS toxicity assays, we identified an exceptionally potent, orally active, neurotrophic molecule called J147 that facilitates memory in normal rodents, and prevents the loss of synaptic proteins and cognitive decline when administered to three - month - old APP / swePS1ΔE9 mice for seven months [7].

Perhaps we should remember the experiments of Francesco Redi, Lazzaro Spallanzani, and Louis Pasteur — basic biological experiments that put to rest the theory of spontaneous generation, the belief that life had arisen spontaneously from dead matter (as, for instance, maggots from rotting meat and mice from bundles of old clothes)-- and not make the same mistake for the origin of the universe itself.

For context in mouse - years, 3 months is sort of like an older teen, and 9 months is about middle - aged.

Two - to 3 - month - old wild - type mice were randomized to sedentary or exercise groups for three to four weeks (A).

Her lab's most recent work, led by HMS Instructor Cristina Aguayo - Mazzucato, started instead with very old mice, created for another experiment, whose beta cells emitted fluorescent signals.

To test the hypothesis that exercise could increase brain progranulin levels in Grn + / − mice, we solo - housed 6 - month - old wild - type (Grn + / +), Grn + / −, and Grn − / − mice in standard mouse cages or cages with running wheels for 7.5 weeks.

We tested this hypothesis by housing 2 - month - old wild - type mice with or without running wheels for 3 — 4 weeks.

We observed no significant effect of genotype for any of these genes (data not shown), indicating that 7 - to 8 - month - old Grn − / − mice have not yet developed the elevated levels of inflammatory cytokines found at older ages (Filiano et al., 2013).

C.C. Little, the inventor of the modern lab mouse and founder of the Jackson Laboratory, had long used «the age old enmity of woman and the Muridae» as a sales pitch for his model organism.