Not exact matches
In 2004 the Nobel Prize in Physiology or Medicine went to Linda B. Buck and Richard Axel
for their research showing that there is a huge family of genes that encode proteins called
olfactory receptors.
The researchers scoured the already deciphered mouse genome, looking
for genes that might encode additional
receptor proteins in its
olfactory system, the sensory cells that connect the nose to the brain.
«Function of
olfactory receptor in the human heart identified: The new findings may be relevant in the long term
for diabetic patients and patients with increased heart rates.»
This visual abstract depicts the discovery that chemosensory
receptors in a subset of mammalian
olfactory sensing neurons are structurally distinct from GPCRs, and multiple subtypes are expressed per neuron, implying an unexpected mechanism
for olfactory detection and decoding.
«The fact that the MS4As have been preserved
for at least 400 million years suggests that these
receptors play a crucial role in enabling animals to interact with the
olfactory environment,» Datta says.
Together, the findings demonstrate that Ggamma13 is essential
for mammals to smell odors and extend the current understanding of how
olfactory receptor cells communicate information about odors to the brain.
Many volatile compounds can now be detected quite well by «electronic noses» that were inspired by the
olfactory receptors of animals and provide characteristic chemical fingerprints
for scents and mixtures of scents.
«New method
for exhaustively isolating
olfactory receptors responding to specific odorants: Step toward the elucidation of a mechanism
for recognizing odorants in mammals.»
A research group led by Osaka University and Panasonic Corporation developed a method
for making a prompt, exhaustive isolation of
olfactory receptors (ORs) responding to the odorant of interest.
However, the researchers did not find any evidence
for an
olfactory system which is based on odorant
receptors in the most basal insect, the jumping bristletail.
For instance, in the human genome we still see the remnants of the large
olfactory receptor gene family that gave our evolutionary ancestors a keen sense of smell, even though humans no longer rely on them.
Each
olfactory neuron codes
for only one of a thousand possible
receptors that respond to particular sniffed compounds.
For this, the key odorous substances have to interact with one or more of the 400
olfactory receptors in the nose.
The pattern of gene expression is strikingly similar to that
for individual
olfactory receptor genes, Liberles says.
Searching
for an explanation to this alternate pheromone - detection system, neuroscientists Stephen Liberles and Linda Buck of the Fred Hutchinson Cancer Research Center in Seattle scanned the mouse
olfactory epithelium
for potential pheromone
receptors.
For humans approximately two - thirds of these receptors are no longer functional, possibly a consequence of the reduced importance of olfactory function for humans as compared to rodents or dogs, for examp
For humans approximately two - thirds of these
receptors are no longer functional, possibly a consequence of the reduced importance of
olfactory function
for humans as compared to rodents or dogs, for examp
for humans as compared to rodents or dogs,
for examp
for example.
Guidepost neurons
for the lateral
olfactory tract: Expression of metabotropic glutamate
receptor 1 and innervation by glutamatergic
olfactory bulb axons.
Cats rely less on their sense of smell
for huntings than dogs do, which is apparent from the smaller repertoire of
olfactory receptor genes in the feline genome.
The «magical world» created by his father became
for Dr. Lomvardas the entry point into the real world of science, where he would one day work with Nobel laureates Eric Kandel and Richard Axel and conduct research into the molecular mechanisms of
olfactory receptors — «one of the most enigmatic and complex problems in biology.»
The benefits of using
olfactory receptor neuron samples to study psychiatric disorders and patient responsiveness include their similarity to brain neurons, the relatively easy biopsy procedure, and the potential
for scientists to sample and compare cells from the same patients throughout several different stages of disease.
Additionally, most of the cancer cell lines expressing
olfactory receptors express the effectors necessary
for OR - mediated signal transduction.
With close to 300 million
olfactory receptors at the end of your pup's snout, he can smell up to 100,000 times more than you, so the Wooly puts your furkid's nose and brain to work by mimicking a hunt
for food in grass or fields.
While this may hold true
for humans equipped with a mere 5 million
olfactory receptors, things are drastically different from a dog's standpoint.
When we breathe, those chemicals are delivered to
olfactory receptors that are found within the nose, and since dogs have over a thousand times more
receptors than us, they experience odors quicker and stronger than us: «Dogs trained
for scent detection also have long noses that very efficiently deliver air to these
olfactory neurons.