Sentences with phrase «for other biomarkers»

Not exact matches

«For the first time, scientists have attempted to account for numbers of people with biomarkers or other evidence of possible preclinical Alzheimer's disease, but who do not have impairment or Alzheimer's dementFor the first time, scientists have attempted to account for numbers of people with biomarkers or other evidence of possible preclinical Alzheimer's disease, but who do not have impairment or Alzheimer's dementfor numbers of people with biomarkers or other evidence of possible preclinical Alzheimer's disease, but who do not have impairment or Alzheimer's dementia.

Unfortunately, the high background of normal proteins, along with the presence of circulating phosphatases and other degradation enzymes, consistently stump researchers searching for these rare tumor biomarkers.

«Adding these two biomarkers provided statistically significant improvement for all early stage cancer versus healthy controls as well as other subcohorts when used with the current gold standard biomarker, CA 19 - 9,» said Ann Killary, Ph.D., professor of Translational Molecular Pathology.

Still, the work of Hahn and colleagues, along with other recent papers, illustrates how the hunt for a concrete biological signature of autism, a biomarker, is gaining speed.

Hariri said he hopes that other researchers looking for biomarkers of mental illness will begin to consider methylation above and beyond DNA sequence - based variation and across different tissues.

These drugs work by targeting the PDL - 1 receptor — a known immunotherapy biomarker for lung and other cancers — to boost immune responses to the cancer.

Serum phosphorus was a significant predictor of progression to the study end point of dialysis initiation (HR 1.44, 95 % CI 10.7 - 1.93), even after controlling for age, sex, race, smoking status, diabetic status, BMI, and other biomarkers.

The team's next avenue of research will be focused on identifying a «biomarker» that can identify this distinct suppressive cell elsewhere in the body — for example, in blood or other samples — as a potential predictive clinical tool to determine when these cells are present in patients, which currently can not be done.

In previous studies, the same group along with others had demonstrated that microRNAs (miRNAs) produced by eukaryotic cells and viruses are present in human blood in highly stable, cell - free forms and these so called circulating miRNAs can serve as non-invasive biomarkers for the early diagnosis of various diseases, including viral diseases.

«The results can also provide information to discover biomarkers for other vaccines based on living vectors.

Dr. Quintana's research is focused on the regulation of the adaptive and innate immune response and the identification of biomarkers for multiple sclerosis (MS) and other immune - mediated diseases.

Knoell says his lab and other researchers are also actively looking for zinc - related biomarkers that can help scientists determine how much zinc is being utilized by the immune system and to help predict who might be at risk for developing sepsis.

The researchers also are seeking other potential drug targets in the 50 percent of patients who don't have high levels of the anti-death protein, as well as biomarkers in addition to CA125 that could be used to screen for ovarian cancer.

In the study, the research team unveiled a smart contact lens sensor that could help monitor biomarkers for intraocular pressure (IOP), diabetes mellitus, and other health conditions.

«This work led by Professor O'Donnell is a technical tour de force, providing a wonderful resource for other biomedical researchers,» said Mike Murphy, Ph.D., programme leader, Mitochondrial Biology Unit at Cambridge University, U.K. «A particularly important aspect is the focus on platelets, which are readily available from patients» blood in diagnosis, prognosis or as a biomarker in assessing therapies.

Dr Margaret O'Hara, from the Molecular Physics Group and primary investigator on the project, said: «Previous studies have found potential biomarkers for liver disease, such as isoprene and acetone, but they are not specific enough because they are possible biomarkers for other diseases or can arise from numerous normal metabolic processes.

«Identifying specific signatures of ribonucleotide incorporation in DNA may represent novel biomarkers for human diseases such as cancer, and other degenerative disorders.»

«Our smart contact lens provides a platform for wireless, continuous, and noninvasive monitoring of physiological conditions, as well as the detection of biomarkers associated with ocular and other diseases,» says Professor Park.

Researchers presenting their work at the American Orthopaedic Society for Sports Medicine's (AOSSM) Specialty Day in San Diego are highlighting how a set of biomarkers on the day of surgery may explain why some individuals have worse PTOA than others after two years.

Other biomarkers and genetic signatures are being used in an effort to predict the aggressiveness of an individual patient's prostate cancer, «but the current information doesn't make it possible for their gene signature to be an actual target for precision medicine targeted therapy,» Ellis explained.

Other areas of medicine have used this approach to define disease processes using biomarkers, for example: bone mineral density, hypertension, hyperlipidemia and diabetes are defined by biomarkers.

For the biomarker study, the Johns Hopkins scientists prospectively analyzed blood samples collected from 141 women with advanced breast cancer (cancer that had spread to other organs) who were beginning a new treatment at seven cancer centers in the U.S., including The Johns Hopkins Hospital.

They also came to the lab for two 48 - hour sessions in which their saliva, blood, and other body fluids were sampled for molecular biomarkers.

Exosomes and exomeres are also detectable in bodily fluids such as lymphatic fluid, which might allow development of biomarkers for early detection of cancer or other pathological conditions.

Current applications include studies related to carbon sequestration, as well as the development of biomarkers for breast and brain cancer, neurological diseases, and diabetes and kidney diseases, among others.

GeneAssess, Inc., is dedicated to developing its breakthrough discovery of the FRY gene as a predictive biomarker for breast and other cancers.

In addition to her expert skill as a clinician, Dr. Frontera also has many research interests including identifying biomarkers and predictors of early brain injury and vasospasm / delayed cerebral ischemia after subarachnoid hemorrhage and their impact on outcome; determining the efficacy of therapeutic strategies and developing guidelines for the management of patients with intracranial hemorrhage; evaluating the cost, length of stay, quality of life, functional and cognitive outcomes in a broader population of intracranial hemorrhage patients; developing guidelines for the integration of palliative care into the intensive care unit setting; and evaluating the relationship of Zika virus infection, Guillain - Barre, and other neurologic disorders.

Unfortunately, the literature supporting the efficacy of DRE and biomarkers other than PSA for screening average risk men provided minimal evidence to draw conclusions.

With further research, the team says the concept could be adapted to monitor other biomarkers besides calcium, to serve as early warning systems for other gradually - developing illnesses like neurodegenerative diseases and hormonal disorders.

UT Southwestern, along with colleagues at seven other academic medical centers and The Leukemia & Lymphoma Society, is enrolling patients 60 and older with newly diagnosed AML in the Master Protocol for Biomarker - Based Treatment of AML (Beat AML) trial.

Akassoglou also thinks fibrinogen and other blood clotting proteins could serve as a biomarker for MS.. A biomarker is a measurable indicator of the presence or severity of a disease, enabling physicians and researchers to track disease progression.

The study authors said the same approach is being applied to a search for biomarkers across a wide range of biological systems, from other infectious agents such as Salmonella to soil microbes of interest in cleaning up toxic waste.

This workshop focuses on considerations for development of a multiplexed immunoassays; examples of multiplexed assays for research release and other toxicities associated with CAR - T cells; and a novel flexible platform for biomarker screening and assessment of toxicities in samples exposed to CAR - T cells.

LC volumetry is potentially more scalable and economical than other potential AD biomarkers, and could be developed for longitudinal screening.

- Other biomarkers which are related to the biomarker for this study.

De Smaele E, Ferretti E, Gulino A. MicroRNAs as biomarkers for CNS cancer and other disorders.

This indicated that HOXA9 methylation levels, as detected via ddPCR technology, could be used in combination with other biomarkers to identify high - risk stage IA and IB patients and potentially steer these patients for follow - up chemotherapy to prevent recurrence.

In 2009 Dr. Drevets became the first President and Scientific Director of the Laureate Institute for Brain Research in Tulsa, OK, a private research institute founded and supported by The William K. Warren Foundation, to lead a multidisciplinary team in studies aimed at investigating interrelationships between neuroimaging, genetic and other biomarkers, illness course, and treatment outcome in psychiatric disorders.

A Clinical Core has capability to safely and efficiently distribute clinical studies of vaccine immunosafety for biomarker discovery from small intensive trials to large - scale studies of adult, paediatric and other populations.

Personalised medicine is becoming relevant in the treatment of lung cancer [42, 43] and may have relevance for other lung diseases, like pulmonary fibrosis, asthma and pulmonary hypertension, but disease - related basic research aimed at searching for biomarkers is needed to achieve personalised and patient - specific treatments for lung diseases.

The expertise displayed by the teams and the platforms of the Department of Translational Research allows the support for maturation of translational research projects (proof of concept in vivo, target / biomarker identification and validation, ancillary biological studies coupled to clinical trials,...) of the Institut Curie alone or in collaboration with other academic teams or industrial partners.

Our NMR - based metabolomics platform has been used by academic researchers to improve risk prediction and for biomarker discovery of cardiovascular diseases, type 2 diabetes and other disease targets.

If these results are confirmed and one or more of these FLT3 - targeted drugs become approved by the FDA, testing for the FLT3 biomarker may eliminate the need for thousands of patients to undergo stem cell transplantation (each allogeneic transplant costs hundreds of thousands of dollars and place recipients at grave risk of infection and other complications such as Graft vs. Host disease).

The tumor suppressor, which could be useful as a biomarker to help diagnose and monitor treatment for liver cancer, could also be relevant for other cancer types.

They're seeing all sorts of other biomarkers that are indicative that we're shifting people into the parasympathetic state, and to me that's like the biggest top of the food chain issue is whether you're in the parasympathetic or whether in the sympathetic, and for me modern life it is very tough to stay having a balance between those two.

Catechol estrogen quinones as initiators of breast and other human cancers: implications for biomarkers of susceptibility and cancer prevention.

Suppose, for instance, that Dan's Plan tracks members» weight, activity, sleep, and other biomarkers, and that Dan's Plan members can share data with their clinicians.

However, you can do your own research by checking your blood for markers auto - antibodies and other biomarkers.

In fact, the new research suggests that testing women for nCyclinE and other biomarkers may help doctors determine which patients would benefit from progesterone supplementation.

Some studies have reported a significant reduction in plasma glucose and hemoglobin A1c levels, 52,53 while others have reported no effect on any aspect of glucoregulatory control.54 Given that dietary polyphenols are rapidly metabolized, one explanation for the discrepant findings between these studies may have been the measurement of the effects of tea on biomarkers at different times after its consumption.