In order to elucidate the mechanism leading to observed coating - dependent toxicities we analyzed the formation of protein carbonyls as an indirect read -
out for the oxidative stress inducing activity of nanoparticles.
We have studied the role of ROS in aging - related impairments in LTP and memory that are associated with normal aging, and have conducted studies to that ROS derived from mitochondria are
responsible for oxidative stress - induced impairments in synaptic plasticity and memory in mice that model AD.
Twelve healthy subjects that consumed 100 grams per day of broccoli sprouts lowered LDL cholesterol, increased HDL cholesterol, and improved
maarkers for oxidative stress (R).
The rats were first treated with kainic acid and phosphate buffered saline (PBS), both of which are substances which scientists use to deliberately increase free radicals so they can then test
treatments for oxidative stress.
Fermentation consumes milk sugars like galactose and lactose — two of the
suspects for oxidative stress — and produces health - protective probiotics, which may be the reason for the difference.
Aging and chronic diseases are strongly associated with
markers for oxidative stress, especially advanced glycation end - products, and resistance to peripheral insulin - mediated glucose uptake.
The neurotrophic and memory - enhancing activities of J147 are associated with an increase in the level of brain derived neurotrophic factor (BDNF) along with the expression of BDNF - responsive proteins, the enhancement of long term potentiation (LTP), synaptic protein preservation, the reduction of markers
for oxidative stress and inflammation, the reduction of amyloid plaques, and lower levels of soluble Aβ1 - 42 and Aβ1 - 40.
MDA is another marker
for oxidative stress.