Sentences with phrase «for photoreceptor function»

The retinal pigment epithelium (RPE) is a monolayer of cells, residing at the back of the eye between Bruch's membrane and the retina, which is essential for photoreceptor function and survival.

Not exact matches

The six previously known fly rhodopsins account for the full function of photoreceptor cells in the fly's eyes, so although the fruit fly genome contained the sequence of a seventh rhodopsin, the role of Rh7 was unclear.

The receptor also regulates DHA retention and conservation in cells in the eye and is necessary for photoreceptor cell function.

Mice lacking the cryptochrome 2 blue - light photoreceptor gene (mCry2) were tested for circadian clock - related functions.

The findings from our proposed studies will further define how the RPE supports the photoreceptor functions via metabolic coupling, and hopefully identify novel druggable targets for preventing RPE and retinal degeneration during AMD.

While preservation of the ONL is evidence for a neuroprotective role for hNPCctx and GDNF within the retina, maintenance of visual function at the level observed in this study suggests at least partial retention of photoreceptor structure necessary for visual processing, particularly that associated with cones.

One can imagine that loss of function of any of the gene products along this complex pathway could lead to severe consequences for the survival of the photoreceptor (PR) cells in the eye.

«For age - related macular degeneration, the best timing might be when the photoreceptors have lost function but haven't yet died off,» she says.

This Clinical Statement provides recommendations for patients with inherited retinal degenerations, which comprise a wide range of genetically and phenotypically heterogeneous diseases associated with progressive loss of photoreceptor function and visual loss.

As a monolayer of cells critical to photoreceptor function and survival, the RPE is an ideally accessible target for cellular therapy.

Although known to have neuronal cell functions STK38L has not previously been associated with abnormal photoreceptor function; being associated with such a disease in dogs establishes this gene as a potential candidate for similar diseases in other species, including man.

A subsequent electroretinography study identified an initial reduction of the cone photoreceptor function which led to the condition being re-classified as a cone - rod dystrophy (CRD), rather than a rod - led PRA, and the disease was termed CORD1 for cone - rod degeneration 1 [36].

Intriguingly, an identical homozygous mutation was identified in a human patient with recessive retinitis pigmentosa, the human equivalent of PRA, and established the novel retinal gene, PRCD, as an important gene for the maintenance of rod photoreceptor structure and function across species.

Whereas the genes implicated in early - onset diseases are those necessary for the correct development of photoreceptors the genes associated with later - onset forms of disease are those necessary for the long - term maintenance and function of these cells.

In general, PRAs are characterized by initial loss of rod photoreceptor function followed by that of the cones and for this reason night blindness is the first significant clinical sign for most dogs affected with PRA.