Sentences with phrase «for placebo controls»

The paper was hailed as further proof of the need for placebo controls in drug trials.

Summit raised the additional capital through an issue of 8,333,333 new ordinary shares (before expenses) whereby the proceeds will be used to: accelerate preparatory activities for a placebo controlled clinical trial of the utrophin modulator ezutromid in patients with -LSB-...]

Not exact matches

After Health Canada demanded a recall of Apotex's mispackaged birth control pills (they contained too many placebos and not enough medication), the U.S. Food and Drug Administration threatened to block Apotex products for «repeated deficiencies,» including bacterial contamination.

If you decide that continuous birth control — or skipping the placebo week — is the right choice for you, you won't experience a period at all.

Although Anavex Life Sciences» Alzheimer's disease program should offer up plenty of data to digest this year, its research program is very early stage, and the company's balance sheet is worrisome enough for me to avoid it until placebo - controlled trial results are available.

A double - blind, placebo - controlled food challenge was conducted for other participants (with a total of 9.4 g of peanut protein administered in increments) in accordance with standard dose - escalation procedures25 (see the study protocol).

The gold standard test (meaning the best way of diagnosing something) for food allergies is a double - blind, placebo - controlled food challenge (DBPCFC), conducted under the supervision of a board certified allergist.

Methods: This randomized, double - blind, placebo - controlled, prospective follow - up study involved 90 coeliac disease patients in remission randomized to consume glucose syrups, maltodextrins or placebo for 24 weeks.

If however many MDs aren't practicing evidence - based medicine, then why not don't MDs * police their own * before going off on other professions for their lack of evidence - base... or attacking what evidence - base there is even if it isn't multiple double - blind placebo controlled studies funded by wealthy drug manufacturers?

Pre-specified subgroup analyses were performed.Six randomised controlled trials were included in this IPDMA, encompassing data from 787 patients (n = 390 for nifedipine; n = 397 for placebo / no treatment).

We searched PubMed, Embase, and Cochrane databases for randomised controlled trials of maintenance tocolysis therapy with nifedipine in preterm labour.We selected trials including pregnant women between 24 and 36 (6/7) weeks of gestation (gestational age, GA) with imminent preterm labour who had not delivered after 48hours of initial tocolysis, and compared maintenance nifedipine tocolysis with placebo / no treatment.The primary outcome was perinatal mortality.

Lactobacillus reuteri for infants with colic: A double - blind, placebo - controlled, randomized clinical trial.

Szajewska H, Gyrczuk E, Horvath A. Lactobacillus reuteri DSM 17938 for the management of infantile colic in breastfed infants: a randomized, double - blind, placebo - controlled trial.

It may also explain why few placebo - controlled studies have managed to find that gluten has any effect, and why it has been so difficult to find out how gluten may cause problems for non-coeliacs, says Gibson.

After following all of the 926 women who completed the trial for 10 months beyond the trial period for pregnancy outcomes, the researchers found that active acupuncture, with or without clomiphene, compared to control acupuncture and placebo medication, did not increase live births.

The women were given active or control acupuncture twice a week in addition to clomiphene or placebo medication for five days per ovulation cycle for up to six months.

The findings are particularly compelling because the drug's benefits lasted for the duration of the 48 - week randomized double - blind, placebo - controlled trial (the most rigorous type of scientific investigation that can be conducted).

For 24 weeks, 1,583 participants in the aptly named GAIT (Glucosamine / chondroitin Arthritis Intervention Trial) were given one of the following treatments: glucosamine, chondroitin sulfate, both in combination, a placebo, or the COX - 2 inhibitor Celebrex (celecoxib) as a control.

The determination of each efficacy level was also based on the rigor and quantity of published studies on the drug class: to be in Level A, for example, a class of drugs must have been supported by at least two «Class I» studies — well - designed, double - blind, randomized, placebo - controlled clinical trials.

They gave one of these groups RC - 101 two days after infection for a total of five days, and gave the other group a placebo control.

«This is the first placebo - controlled, randomized study of a vaccine for glioblastoma to show a significant benefit in a clinically meaningful endpoint, progression - free survival.

A control group was given a placebo for the same period of time.

Yale enrolled the largest number of participants at any one site (84 of 790) for these double - blind, placebo - controlled trials that investigated the efficacy of testosterone gel for multiple outcomes, including sexual function, physical function, and vitality.

Kosten recently completed the first placebo - controlled clinical trial for a cocaine addiction vaccine.

Ayurvedic medicine was practiced for thousands of years before anyone invented the placebo controlled experiment.

In a controlled clinical trial published in 2005 in Gastroenterology, Weinstock and his colleagues gave 52 participants with colitis 2,500 pig whipworm eggs or a placebo every two weeks for three months.

Budimirovic says the current study updated the 2013 recommendations by using a more systematic approach that classified existing outcome measures as either being able to detect shorter - term changes (measures in FXS placebo - controlled trials lasting less than 12 months) or longer - term changes (lasting longer than 12 months) changes and by grading the measures» quantitative properties using the COnsensus - based Standards for the selection of health Measurement Instruments (COSMIN) system, an initiative that aims to improve how health measurement tools are selected.

For this placebo - controlled and age - matched functional magnetic resonance imaging study a total of 28 subjects were included (only males, mean age = 27.09, SD ± 7.06).

Well - designed, placebo - controlled trials of the drug in men who do not meet the standard criteria for treatment have been scant in number, and their results have been inconsistent.

Belviq has also shown promise for people with type 2 diabetes, who were twice as likely to keep their blood sugars under control than those on the placebo.

Half the men (the experimental group) applied a gel with testosterone to their shoulders, abdomen or upper arms each day for a year, and the other half (the control group) used a gel containing a placebo.

Even though such randomized placebo - controlled trials can take years to conduct, they offer the best hope for separating truth from wishful thinking.

For comparison the team also analyzed mice in a control group that were given a placebo instead of Salmonella infection.

The diagnostic «gold standard» for food allergy is a placebo - controlled test.

A new report on the ethics of Ebola, released today by the U.S. Presidential Commission for the Study of Bioethical Issues, takes a nuanced view of the questions about study design; the committee doesn't rule out placebo - controlled studies but allows room for other designs as well.

Using a randomized, placebo - controlled clinical trial (RCT) design, they randomized 48 participants into four equal groups of 12 people: low - to - moderate intensity, high - volume aerobic exercise (LO: HI); high - intensity, low - volume aerobic exercise (HI: LO); low - to - moderate intensity, low - volume aerobic exercise (LO: LO); and placebo (PLA) for an eight - week period.

In one placebo - controlled trial, researchers treated elderly patients suffering from dementia with 1.6 g daily of oxiracetam for 12 weeks and reported significant improvements in several measures of memory and concentration.

«If the treatment takes several hours, people may not volunteer for a placebo - controlled study,» says Wyss - Coray.

Acetazolamide has been used for decades as a respiratory stimulant for patients with COPD and metabolic alkalosis (an increase in the alkalinity of body fluids due to an increase in alkali intake or a decrease in acid concentration), but no large randomized placebo - controlled trial has been available to confirm this approach.

FDA - approved pharmaceuticals for alleviating angina have about a 55 percent effectiveness level in randomized controlled trials; the placebo runs about 45 percent.

Maharaj and Trevino call for larger, placebo - controlled studies of potential treatments for PMDD.

«Both physical functioning and quality of life are severely affected, and while many treatments are used to relieve symptoms and try to get the disease under control, this largest set of placebo - controlled information to date clearly shows that improvement can result for patients.»

(B) Individual DV values in cerebellum and putamen after placebo (PL) and after MP for the marijuana abusers and the controls.

Statistical information for clusters showing significant changes for BPND in marijuana abusers and in healthy controls for the contrast placebo BPND > MP BPND, and for clusters showing significant differences for ΔBPND for the contrast marijuana abusers > controls (A > C)

Statistical group analyses were based on a factorial repeated ANOVA SPM8 model with two groups (marijuana abusers and controls) and two conditions (placebo and MP) and a covariate [parts per million levels of carbon monoxide (CO), a marker for tobacco smoking (40)-RSB-.

(A) SPM results for the comparison of MP vs. placebo on the BPND images from [11C] raclopride in marijuana abusers (MA) and in healthy controls (HC)(Puncorr < 0.005) and group comparisons for the effects of MP (ΔBPND)(P < 0.01, cluster size of 10 voxels).

John DeLuca, PhD, VP of Research & Training chairs Workshop 6: Cognitive Rehabilitation in MS. Dr. DeLuca discusses assessment of cognitive problems and introduces common evidence - based techniques for improving cognitive functioning in persons with MS. Nancy Chiaravalloti, PhD, director of Neuropsychology & Neuroscience Research, presents two recent double - blind, placebo - controlled, randomized control trials of behavioral interventions designed to specifically improve learning and memory in persons with MS. Yael Goverover, PhD, OT, focuses on techniques to improve learning and memory, with a specific emphasis on improving everyday functional activity.

* Results from a Randomized Placebo - Controlled Clinical Trial of a RBX2660 — a Microbiota - based Drug for the Prevention of Recurrent Clostridium difficile Infection — Erik R Dubberke — Clinical Infectious Dieases

Of note today: non-exclusive breastfeeding increases the risk of HIV transmission via the alteration of gut microbiome / T - cell activation; Fasting altered the gut microbiome in beneficial ways but only in mice previously fed a high fat diet; An investigation into new species of the honey and bumblebee gut commensal genus Gilliamella; Catfish development shapes gut microbial community structure independent of diet; A metagenomic analysis of the skin microbiome of the frog, Craugastor fitzingeri; The microbiome is altered during the bioremediation of herbicide contaminated soil; The impact of urban density on the soil microbiome; A randomized placebo controlled clinical trial of a microbiota based drug for the prevention of Clostridium difficile Infection; and the virome of the Cuatro Ciénegas Basin of Mexico

Part 1 of the study is a double - blinded, placebo - controlled, randomized exploratory dose - finding study in approximately 36 patients for 12 weeks to evaluate the safety of RG7916 and to select the dose for Part 2 of the study.