Sentences with phrase «for potential clinical applications»

Finally, Eng described new genomics advances including whole genome sequencing for potential clinical application with its opportunity for changing the paradigm of healthcare and its multiple attendant challenges.

Not exact matches

Actual results and the timing of events could differ materially from those anticipated in the forward - looking statements due to these risks and uncertainties as well as other factors, which include, without limitation: the uncertain timing of, and risks relating to, the executive search process; risks related to the potential failure of eptinezumab to demonstrate safety and efficacy in clinical testing; Alder's ability to conduct clinical trials and studies of eptinezumab sufficient to achieve a positive completion; the availability of data at the expected times; the clinical, therapeutic and commercial value of eptinezumab; risks and uncertainties related to regulatory application, review and approval processes and Alder's compliance with applicable legal and regulatory requirements; risks and uncertainties relating to the manufacture of eptinezumab; Alder's ability to obtain and protect intellectual property rights, and operate without infringing on the intellectual property rights of others; the uncertain timing and level of expenses associated with Alder's development and commercialization activities; the sufficiency of Alder's capital and other resources; market competition; changes in economic and business conditions; and other factors discussed under the caption «Risk Factors» in Alder's Annual Report on Form 10 - K for the fiscal year ended December 31, 2017, which was filed with the Securities and Exchange Commission (SEC) on February 26, 2018, and is available on the SEC's website at www.sec.gov.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

«For several years the potential for the use of gene expression data in research and clinical applications has been underappreciated due to the inconsistency of the data coming from the various types of equipmeFor several years the potential for the use of gene expression data in research and clinical applications has been underappreciated due to the inconsistency of the data coming from the various types of equipmefor the use of gene expression data in research and clinical applications has been underappreciated due to the inconsistency of the data coming from the various types of equipment.

As their novel technique for drug delivery is non-invasive and easy to use, the NUS team envisioned that the microneedles patch has great potential for applications in clinical and home care settings for the management of perioperative pain and chronic pain in patients suffering from conditions like diabetes and cancer.

A challenge in developing clinical applications is the potential for off - target effects that could result in DNA cleavage at the wrong locations.

«This result has strong application potential» says Dr. Parise, who has just accepted a new position as research scientist at Oculus VR (Facebook): «A deep understanding of multisensory processing opens new clinical perspectives for neurological syndromes that are associated with multisensory impairments, such as Autism Spectrum Disorder and Dyslexia.

«Although this application is not certified at present for use in health care by any regulatory body, our study highlights the potential for smartphone - based diagnostics to aid in clinical decision - making at the patient's bedside,» concludes Dr. Hibbert.

In addition to proposing several conditions for initial investigations, the report recommends principles to guide the potential trajectory of MRT from research to clinical applications.

At Houston Methodist, fostering innovations with the potential for clinical application is at the very heart of what we do.

However, Shinya Yamanaka's formula for iPSCs, for which he was awarded last year's Nobel Prize, uses a strict recipe that allows for limited variations in human cells, restricting their full potential for clinical application.

Despite its potential broad applications, clinical development of Hu5c8, a monoclonal antibody intended for treatment of autoimmune disorders, was terminated due to unexpected thrombotic and cardiovascular events in patients.

The AgedBrainSYSBIO consortium is coordinated by the French National Institute for health and medical research (Inserm, Prof. Michel Simonneau) and brings together an scientists with internationally recognized expertise in systems biology of the synapse and four small to medium size enterprises (SMEs) with a leading role in the project to assure the innovation potential and translation of project results to clinical application.

«The inflammation resolving targeted nanoparticles have shown exciting potential not only for the potential treatment of atherosclerosis as described here, but also other therapeutic areas including wound repair, for example, as described in the Feb. 9 online issue of Journal of Clinical Investigation, in addition to other applications currently underway with our collaborators,» Farokhzad said.

As for any innovation with potential medical applications, hiPSCs must satisfy a great number of criteria prior to their introduction into clinical practice.

Nanopore sequencing, a novel genomics technology, has potential applications for routine biosurveillance, clinical diagnosis, and outbreak investigation of virus infections.

Through interactions with its sister groups in the Bench to Bassinet program, the CvDC will identify and pursue those basic discoveries in cardiac regulatory networks with the greatest potential to translate to clinical applications for treatment and prevention.

More than 3,000 years of recorded use, as well as modern clinical research in both humans and animals, suggest a wide range of potential applications for BLACK CUMIN SEED OIL ORGANIC - from helping to balance the gut microbiome to benefitting epidermal structure and appearance.

Until we know more about the validity of in vitro methods, it is not recommended that they be used in clinical or epidemiologic research applications or for food labeling purposes because of the potential for large over - or underestimates of true GI values.

In a review published in the Journal of Feline Medicine and Surgery, Jessica M. Quimby, DVM, Ph.D., DACVIM, Department of Veterinary Clinical Sciences at The Ohio State University, and Dori L. Borjesson, DVM, MPVM, Ph.D., Veterinary Institute for Regenerative Cures at the University of California, Davis, consider both the current and potential clinical applications of mesenchymal stem cell therapy Clinical Sciences at The Ohio State University, and Dori L. Borjesson, DVM, MPVM, Ph.D., Veterinary Institute for Regenerative Cures at the University of California, Davis, consider both the current and potential clinical applications of mesenchymal stem cell therapy clinical applications of mesenchymal stem cell therapy in cats.