Sentences with phrase «for preclinical testing»

Humanized mouse models for preclinical testing.

«Not only does this research provide compelling evidence for further investigation of immunotherapy for treating stomach cancer, it also provides the first model for preclinical testing of these treatments.»

Dr N.Karagianni, Biomedcode's CSO, participates as an expert at MouseAGE COST action a European network for preclinical testing of interventions in...

Not exact matches

Preclinical testing is important for financial reasons.

Preclinical and clinical tests have been used successfully in the past for the introduction of therapies for bone marrow transplantation and the regeneration of skin and cornea in patients.

Jones added that hope is on the horizon through preclinical trials that are testing several amphetamine - like drugs for effectiveness in treating cocaine addiction.

«To better understand safety issues, we are making efforts to employ more modern investigational, molecular approaches to safety assessment — and increase our safety testing work force by about 10 percent,» says Phil Bentley, vice president and global head of preclinical safety at Novartis Institutes for BioMedical Research in New York City.

Indeed, their combined phenotypic screening and target - identification approach enabled them to quickly discover, characterize and carry out preclinical tests of a potential new drug for obesity - linked diabetes: a complex metabolic disorder that affects 347 million people worldwide.

If these preclinical studies are successful, the researchers plan to further develop their CAR T cell therapy and test its safety and efficacy for different types of metastatic cancer in upcoming clinical trials.

«Simple, sensitive, and cost - effective assays for analyzing Fragile X-related disorders: Tests useful for preclinical and clinical research on a genetic mutation related to autism and intellectual disability may become more available.»

UNITY has completed a rigorous screening and preclinical testing process of candidate drugs, discovered in this study, and is launching a new clinical trial to assess its first drug, for patients with osteoarthritis of the knee this year.

GLP regulations and guidelines for the conduct of preclinical testing ensure the quality and integrity of data submitted in support to the development of new treatments, foster mutual acceptance of data in the international community, serves to minimise redundant testing, minimize animal use and maximise protection of human health.

Based on these preclinical findings, CRI provides a seed grant for a phase I clinical trial to test the strategy in patients with metastatic renal cell carcinoma.

The collaboration will combine Lysogene's outstanding translational and clinical expertise in gene therapy for CNS disorders with the unique preclinical expertise and infrastructure of UMMS and AU to design and test innovative AAV - based gene therapy approaches to treat GM1 - gangliosidosis.

W. Bogers: PhD in immunology and 20 years of experience with NHP models for the preclinical evaluation of HIV vaccine candidates as well as testing antivirals.

CRI provides a pilot grant to Jean - Pierre Mach for preclinical studies to test a new cancer immunotherapy strategy using anti-tumor antibody fragments conjugated to antigenic MHC / peptide complexes.

All this information is necessary before preclinical safety testing and product development for an AMD therapy in humans can take place.

Unprecedented scale, with the capacity to produce up to 1,000 unique mRNA constructs per month, for research, drug discovery and preclinical testing — with a cycle time of a handful of weeks;

The patents also cover second and third generation GAIM - based therapeutic candidates currently in preclinical testing for other protein misfolding diseases of the central nervous system, including Alzheimer's, Parkinson's and tauopathies, and in peripheral amyloidoses.

«We have enough preclinical information to support the rationale for testing this new drug in the clinic,» El - Deiry said.

In order to efficiently evaluate the newly designed vaccine candidates before testing them in clinical trials there is a need for development of reliable preclinical models.

This model offers unique capabilities for preclinical assessment of thrombosis risk in a patient - specific manner, including efficacy testing of anti-thrombotic agents, elucidation of mechanism of action, and, potentially, biomarker identification, all providing a much - needed platform for drug discovery and development.

AFF 1: Preclinical Efficacy Data AFF 1 was then tested for preclinical efficacy in two models of human synucleinopathy: mThy1 - AS mice, and also PDGF - AS mice expressing WT human AS under the PDGF - β promoter — a model with closer neuropathological and metabolic resemblance to LPreclinical Efficacy Data AFF 1 was then tested for preclinical efficacy in two models of human synucleinopathy: mThy1 - AS mice, and also PDGF - AS mice expressing WT human AS under the PDGF - β promoter — a model with closer neuropathological and metabolic resemblance to Lpreclinical efficacy in two models of human synucleinopathy: mThy1 - AS mice, and also PDGF - AS mice expressing WT human AS under the PDGF - β promoter — a model with closer neuropathological and metabolic resemblance to LBD than PD.

Dr. Putoczki said the preclinical model would be very useful for testing new treatment options, such as immunotherapy.

Such models will allow for further understanding of critical genes and microRNAs involved in sarcoma development, progression and metastasis and can be utilized as preclinical models for therapeutic testing and efficacy.

Jones added that hope is on the horizon through preclinical trials that are testing several drugs for effectiveness in treating cocaine addiction.

Then, in preclinical models of MYCN leukemia, the researchers tested a strategy of knocking out the gene for the safety - valve protein.

Therefore the group: i) characterizes the specificity of these antibody responses to identify relevant targets for a vaccine; ii) developes new approaches to test antibody responses; and iii) adoptes the immunological analysis in preclinical (in rabbits and macaques) and clinical vaccines studies to identify predictive signatures for the development and prioritization of new HIV - 1 vaccine candidates.

The diverse group of experts has developed a biorepository of patient - derived tissues, which will be used for testing investigational drugs in preclinical models.

Such models will allow for further understanding of critical genes and microRNAs involved in sarcoma development, progression and metastasis and utilized as preclinical models for therapeutic testing and efficacy.

Oversaw mechanical testing and quality control for the production of biologic products for research and preclinical projects