Sentences with phrase «for programmed cell death»

Earlier research suggests these compounds are able to negatively affect critical cancer cell mechanisms, such as those responsible for programmed cell death (apoptosis) and for proliferation.

Biologists often view cancer primarily as a genetic program gone wrong, with mutations and epigenetic changes producing cells that don't behave the way they should: Genes associated with cell division and growth may be turned up, and genes for programmed cell death may be turned down.

PD - 1, which stands for programmed cell death 1, is the second immune checkpoint pathway currently being targeted with immunotherapies.

Once activated, the mechanism for programmed cell death shrinks the cell's nucleus, decreases the cell's fluid, or cytoplasm, and snips up the cell's DNA.

Not exact matches

However, Brenner, who together with two others, has just received this year's Nobel Prize in Physiology or Medicine for their discoveries concerning «genetic regulation of organ development and programmed cell death,» maintains that nothing has changed for him.

This pathway, the investigators report in Nature Medicine, is very similar to apoptosis (the controlled cell death program thought to exist only in multicellular organisms), but with subtle differences suggesting that it could be specifically targeted for anti-parasitic or - microbial drug development.

Joint winners of the 2002 physiology or medicine prize «for their discoveries concerning genetic regulation of organ development and programmed cell death.»

With few exceptions, these cells still die, suggesting that, in nematodes, engulfment is not necessary for most programmed deaths.

Leonard Hayflick, the scientist who discovered that cells have a programmed moment of death, says that there is a natural age limit for organisms, that things wear out and die.

For instance, Hohl and his colleagues noticed that fungal cells being engulfed by neutrophils, a type of white blood cell, appeared to be undergoing programmed cell death.

So the shark - specific signature of adaptation found in the Bag1 gene may indicate an alternative, or modified role for this important gene — one that could alter its tendency to inhibit programmed cell death in sharks.

If the compound identified in this study successfully reduces tissue death and improves recovery in further experiments, it could lead to new approaches for preserving brain cells after an ischemic stroke,» said Francesca Bosetti, Ph.D., Pharm.D., program director at the NIH's National Institute of Neurological Disorders and Stroke (NINDS).

Students in the UBC program engage in a wide range of research: molecular mechanisms underlying cell proliferation in cancer or cell death in stroke; relating gene mutations to disease mechanisms; the social factors that determine access to health care for women living on the street.

The Bag1 gene, for example, codes for a protein that in humans is involved in inhibiting an essential natural process called «programmed cell death.»

The American Society of Hematology Policy Statement on Screening for Sickle Cell Trait and Athletic Participation opposes mandatory screening of athletes for sickle cell trait as a prerequisite to athletic participation and urges athletics programs to adopt universal preventive interventions in their training programs to protect all athletes from exertion - related illness and deCell Trait and Athletic Participation opposes mandatory screening of athletes for sickle cell trait as a prerequisite to athletic participation and urges athletics programs to adopt universal preventive interventions in their training programs to protect all athletes from exertion - related illness and decell trait as a prerequisite to athletic participation and urges athletics programs to adopt universal preventive interventions in their training programs to protect all athletes from exertion - related illness and death.

There, in a quest to develop targeted therapies for ovarian cancer, she began studying necroptosis, a form of programmed cell death.

Most are destroyed by the immune system or their own programmed cell death mechanisms, but enough linger for the long term for their growing presence to be one of the contributing causes of the aging process.

The rationale for using CT - 011, an immunotherapy antibody that blocks the programmed death (PD)-1 receptor, is to boost the function of the immune system by inhibiting PD - 1 whose function, in part, is to inhibit T - cell response.

Background: Expression of programmed death ligand (PD - L1 / B7 - H1 / CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells.

For this he shared the 2002 Nobel Prize in Physiology or Medicine with Sydney Brenner and John Sulston «for their discoveries concerning genetic regulation of organ development and programmed cell death.&raqFor this he shared the 2002 Nobel Prize in Physiology or Medicine with Sydney Brenner and John Sulston «for their discoveries concerning genetic regulation of organ development and programmed cell death.&raqfor their discoveries concerning genetic regulation of organ development and programmed cell death.»

For example, new combinations of domains in death-fold domain proteins and laminins possibly allow for the modification of protein interactions and pathways involved in programmed cell death and cell adhesion, respectively (Supplementary Note 9.3), and the co-option of sponge -, eumetazoan - or bilaterian - specific architectures into novel functioFor example, new combinations of domains in death-fold domain proteins and laminins possibly allow for the modification of protein interactions and pathways involved in programmed cell death and cell adhesion, respectively (Supplementary Note 9.3), and the co-option of sponge -, eumetazoan - or bilaterian - specific architectures into novel functiofor the modification of protein interactions and pathways involved in programmed cell death and cell adhesion, respectively (Supplementary Note 9.3), and the co-option of sponge -, eumetazoan - or bilaterian - specific architectures into novel functions.

Programmed death 1: a critical regulator of T - cell function and a strong target for immunotherapies for chronic viral infections.

New data and research approaches have created opportunities for researchers to study in detail many aspects of cancer biology, including how the normal biological programs of cell proliferation and death are altered during cancer and how the immune system responds to tumors.

This more recent study not only supports earlier findings, but sheds new light on the molecular mechanisms taking part in programmed cell death, paving the way for future studies of anti-cancer effects of strawberries and other foods.

In addition to this, the mitochondria are responsible for regulating apoptosis (programmed cell death).

Adequate zinc status is essential for T - cell division, maturation and differentiation; lymphocyte response to mitogens; programmed cell death of lymphoid and myeloid origins; gene transcription; and biomembrane function.