The revised and updated standards include special attention to standards
for replication studies and scaling up of effective interventions.
Exciting new findings are a route to tenure and fame, and there's little reward
for replication studies.
FIREPAW researchers assisted colleagues in the Bahamas in providing supporting statistics
for their replication study of the FIREPAW research study on Companion Animals Guardians vs. Owners.
Not exact matches
At the Salk Inst.itute
for Biological
Studies, in 1994, Leslie Orgel observes, «Because synthesizing nucleotides and achieving
replication of RNA under plausible prebiotic conditions have proved so challenging, chemists are increasingly considering the possibility that RNA was not the first self replicating molecule...» (9).
A new
study by Robert Stahelin, an adjunct associate professor of chemistry and biochemistry at the University of Notre Dame and an associate professor at the Indiana University School of Medicine - South Bend, as well as a member of Notre Dame's Eck Institute
for Global Health, investigates how the most abundant protein that composes the Ebola virus, VP 40, mediates
replication of a new viral particle.
On 20 December, the United States government — acting on advice from the US National Science Advisory Board
for Biosecurity (NSABB)-- asked both journals to publish only the main conclusions of two flu
studies, but not to reveal details «that could enable
replication of the experiments by those who would seek to do harm» (see «Call to censor flu
studies draws fire»).
University of Virginia psychology professor Brian Nosek and his colleagues at the nonprofit Center
for Open Science got help from over 350 scientists to repeat 100 high - profile psychology experiments published in 2008 — the largest
replication study to date.
Our independent scientific advisory board — all members of which are leaders in their fields as well as advocates on the reproducibility problem — selects
studies for replication.
The authors caution that further
study and
replication of their results in different populations is needed to verify their model before it will be useful
for individual genetic tests — or before longevity «cocktails» are created.
These included tests
for how much variance surrounded the main statistics of the
studies, the sample size, the likelihood of
replication, and the estimated power of the tests before and after the data was collected.
The oldest
study up
for replication is one published in Science in 1960 by Eckhard Hess and James Polt of the University of Chicago in Illinois.
But doing a
replication study just
for the sake of checking whether the original author made a mistake isn't smart, he says.
The trick, he says, is in seeing
replication not as an end in itself but as a means
for acquainting yourself with the methods used in a
study, the original author's line of thinking, the complications he or she must have faced, and the solutions they devised to those problems.
The standards include citation standards
for journals, data transparency, analytic methods (code) transparency, research materials transparency, design and analysis transparency, preregistration of
studies, preregistration of analysis plans and
replication.
Dr. Jones obtained his Ph.D. in 2003 from the University of Birmingham Institute of Cancer and Genomic Sciences (United Kingdom) under Professor Lawrence Young,
studying the use of gene therapy
for targeting Epstein - Barr Virus (EBV) proteins with
replication - competent adenoviruses to treat EBV - driven malignancies.
From such
studies came the current canonical model of how venom genes evolve through the chance
replication and mutation of genes
for enzymes, peptides and other proteins.
They find a role
for viral
replication in explaining serotype - specific differences in viral load — according to a new
study published in PLOS Computational Biology.
However, if the promises of findings reported in the
studies by Mahajan and colleagues and Herberg and colleagues are fulfilled by
replication and refinement in other rigorous investigations, it may be possible that such advances will further reduce morbidity, mortality, and costs associated with caring
for febrile children.
«My goal is to make sure EPA does not rely on scientific
studies unless the data is made available
for replication by somebody.»
For the new
study, Geisbert and his colleagues used snippets of so - called small interfering RNAs (siRNA), which can tinker with a virus's
replication.
Results from the field's biggest
replication study yet make it clear psychology has room
for improvement.
The screening procedure — used in the U.S. to model and
study virus
replication — allows
for continuing evaluation of new antivirals or anti-Ebola drugs, since there is a likelihood of future Ebola outbreaks.
Pending approval through an Investigative New Drug Application, the aerosolized form of the vaccine will be evaluated
for replication, safety and immunity development in a
study in adults.
Researchers should more widely share information that allows
studies to be replicated, says the new report, and funding agencies should make more money available
for replication.
For each paper a Registered Report detailing the proposed experimental designs and protocols for the replications is peer reviewed and published prior to data collection; the results of these experiments are then published as a Replication Stu
For each paper a Registered Report detailing the proposed experimental designs and protocols
for the replications is peer reviewed and published prior to data collection; the results of these experiments are then published as a Replication Stu
for the
replications is peer reviewed and published prior to data collection; the results of these experiments are then published as a
Replication Study.
Roger J Davis was the eLife Reviewing Editor
for the Registered Report (Chroscinski et al., 2014) and the
Replication Study (Horrigan et al., 2017).
Psychologists also tackled problems of publication bias head - on, he said, referring to a tendency
for studies that are new and flashy to get more space in the journals than
replications of previous work; that's the case even though
replications are what show that science is strong.
«This impressive work demonstrates a new mechanism
for how a relatively simple genetic network can respond to external cues and create the most optimal environment
for viral
replication,» said Gurol Suel, PhD, an associate professor of molecular biology at UCSD who was not involved in the
study.
Nevertheless a role
for these cells can not be excluded, it is possible that an incomplete
replication of the suppressive microenvironment in vitro or indeed the diversity of Treg populations mean that these
studies do not fully explore the potential role of suppressive or regulatory T cells in promoting MSC tolerance.
Additionally, a more intense
study for virus
replication including quantitative RT - PCR assays might have confirmed the probability that virus
replication is required
for induction of the immunopathology after vaccination.
In our
study, we found that the emergence of a small non-adherent subpopulation (approximately 1 %) survived after the first hypoxia / reoxygenation cycle and speculate that cyclic exposures of hypoxia and reoxygenation may select
for the stem - like subpopulation with the ability to overcome
replication arrest whereas the majority of non-adherent cells can not.
Skol, A.D., Scott, L.J., Abecasis, G.R. & Boehnke, M. Joint analysis is more efficient than
replication - based analysis
for two - stage genome - wide association
studies.
Our results provide an important resource
for studies of EBV
replication.
«However,
replication studies with various types of resistance exercise programs and high protein diet are required in order to confirm the results of the present
study for current practice in the field.»
Replication of knowledge and single correct responses are inadequate preparation
for students entering vocations or going on to higher academic
studies.
The Arts in the Classroom Professional Development program was identified as an arts education model by the U.S. Department of Education
for study and potential
replication.
Finally, Steven Rouk (Mercy
For Animals) will conduct a
replication and extension of their 2015
study examining which characteristics of social media posts are associated with the highest number of impressions.
These reproductions were intended
for study and further
replication through figure drawing or as models
for paintings.
Professor JPA Ioannidis has made a career out of pointing out where epidemiology
studies show poor
replication, and the consequent implications
for clinical practice.
For every
study, there are pointless obstacles to
replication, causing long delays to any statistical researcher attempting to evaluate the results.
Most of the key
studies in the IPCC report have not archived their data and refuse to release their data or software code to any skeptic
for replication
So the question I would like to ask is: would it help to have a formal requirement
for publicly funded scientists to do
replication studies in addition to their original work?
Where the nature of the
study precludes direct
replication by experiment, as in the case of time - dependent field measurements, it is important that the requirements include access to all the original raw data and its provenance, together with the criteria used
for, and effects of, any subsequent selections, omissions or adjustments.
I would hasten to add that McIntyre's claims about the lack of «
replication» in the
study is pure BS, based once again on, perhaps deliberate, misunderstanding of the requirements
for an accurate standardization curve.
Tags
for this Online Resume: Lentiviral Retroviral shRNA RNA knockdown screens, Flow Cytometry, RTPCR, Immunopreciptations, Reporter assays, Cell based Assays, ELISA, Migration, Stable and Transient Transfections, Genomic and Proteomic
Studies, Cloning, Transient siRNA knockdowns, Phenotyping Mammalian cell lines, Gene Overexpression, Subcloning to expression Vectors, Construct Stable Inducible Cell lines, Protein Kinase Assay, Pulse Chase Experiments, Transfection, Transduction, Transformation, Polyoma virus DNA tumor virus
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The National Comorbidity
Study Replication,
for example, found that during a 12 month period - and among those receiving treatment
for mental health concerns - the median number of clinic visits was 2.9 (Wang et al., 2005).
As a result,
replication studies should address this possibility and examine whether the gene × gene interaction is found
for covert antisocial phenotypes.
Although some were quick to embrace the findings of these earlier
studies as evidence that home visitation improves outcomes
for all women and children, Olds and Kitzman emphasised the need
for further systematic evaluation and
replication.3
Although there was adequate power to detect associations in this
study because the sample was enriched
for maltreatment experiences and psychopathology, independent
replication is warranted.
The
replication studies comprised 744 German patients with MDD and 921 African American nonpsychiatric clinic patients, of whom 152 and 119 were positive
for SA, respectively.