Sentences with phrase «for resistance to therapies»

«Considering that frequent amplification of MET accounts for resistance to therapies now in development and to poor prognosis, not only in ovarian cancer but in other cancers too, our findings pinpoint an important new signaling hub, involving the role of FER in MET activation.

Whilst further study is needed, we are building evidence to show that genetic diversity in a bacterial infection or in a tumour being treated could lay the foundation for resistance to the therapy and affect how quickly resistance develops.»

Not exact matches

I won't reveal yet who my favorites are, but I will say that these young scientist - founders came up with very creative solutions for preventing infections in some common surgeries, tackling resistance in targeted antibody drugs, improving gene vectors for cell therapies, helping the vision - impaired «see» faces and better read their environments, imaging hard - to - see spots in the lungs and other organs, improving genetic risk analysis, and expediting the logistical operations of hospitals.

Currently, many patients who acquire resistance to EGFR - targeted therapy undergo a tumor biopsy and are designated as either positive or negative for specific secondary mutations.

Now a University of Colorado Cancer Center study published online ahead of print in the journal Oncogene offers compelling evidence explaining this failure and offering a possible strategy for the use of retinoic acid or other retinoids against some breast cancers: Because early clinical trials are often offered to patients who have already tried other more established therapies, breast cancer cells may have been pushed past an important tipping point that offers retinoic acid resistance.

Tissue engineering provides a more practical means for researchers to study cell behavior, such as cancer cell resistance to therapy, and test new drugs or combinations of drugs to treat many diseases.

The analysis suggests that alternative therapies for certain mild infections — which may be easier to develop — could indirectly slow development of antibiotic resistance in more dangerous bugs.

Many leukemias acquire a resistance to the TKIs used for the therapy over time, and the patient suffers a relapse.

If these peptides are developed for therapeutic use, the researchers anticipate that they could be used either in stand - alone therapy or together with traditional antibiotics, which would make it more difficult for bacteria to evolve drug resistance.

To compensate for this shortcoming, combination therapy attempts to hit a virus at so many places simultaneously that it can not develop resistance to them alTo compensate for this shortcoming, combination therapy attempts to hit a virus at so many places simultaneously that it can not develop resistance to them alto hit a virus at so many places simultaneously that it can not develop resistance to them alto them all.

«We believe this discovery is a promising avenue for developing a new therapy to reduce chemo - resistance in women with this deadly disease,» said Dr. Dar - Bin Shieh, collaborative partner from National Cheng Kung University of Taiwan.

Insulin resistance allows hibernating bears to break down their fat stores, and finding out how they do it could lead to therapies for type 2 diabetes

«By helping us understand that lower levels of RNF125 confer resistance to BRAF inhibitors, we have a new strategy to stratify patients for currently approved therapy versus participation for human clinical trials to investigate whether targeting JAK1 will be more effective in patients whose tumors exhibit reduced RNF125,» said Keith T. Flaherty, M.D., associate professor, Harvard Medical School, and director of Developmental Therapeutics, Cancer Center, Massachusetts General Hospital, and co-author of the study.

In future, Bandyopadhyay says, better understanding how chemotherapy agents impact specific biological pathways should allow drug trials to focus on patients who are more likely to respond to the drugs being tested and enable clinicians to identify targeted or combination therapies for patients with a genetic predisposition to resistance.

In their report that has received advance online publication in Nature Nanotechnology, a research team based at the Wellman Center for Photomedicine at Massachusetts General Hospital (MGH) describes how a nanomedicine that combines photodynamic therapy — the use of light to trigger a chemical reaction — with a molecular therapy drug targeted against common treatment resistance pathways reduced a thousand-fold the dosage of the molecular therapy drug required to suppress tumor progression and metastatic outgrowth in an animal model.

The other study — Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma — published March 30, shows how drugs targeting PI3K and MAPK could represent promising candidates for glioblastoma therapy.

However, these patients will eventually develop resistance to EGFR TKI therapy and a further EGFR mutation called T790M accounts for 60 % of this acquired resistance.

These findings identify specific BRCA1 mutations that are more likely to develop therapy resistance, which may lead to more accurate predictions and personalized treatments for breast and ovarian cancers.

The researchers say their method offers a new explanation for how to prevent cancer cells from becoming treatment - resistant and how combinations therapies can be developed to overcome drug resistance.

«Understanding how the drugs work gives us the opportunity to investigate new treatments, for example by using combination therapies, or altering the dosage and timing of treatment to prevent drug resistance from emerging,» Dr Glaser said.

«Using a novel model we developed to facilitate discoveries about the growth and spread of lymph node metastases, we show that angiogenesis does not occur in lymph node metastases, providing a mechanism for resistance to angiogenic therapy in these situations.»

Shokat and his colleagues wanted to get ahead of this problem, and began thinking about third - generation mTOR inhibitors without waiting for patients to develop resistance to the latest therapies.

«Figuring out why resistance to targeted therapies develops has been the focus of our research for a long time,» says Paul Mischel, the paper's co-corresponding author, at the Ludwig Institute for Cancer Research at the University of California, San Diego.

Increasing resistance to existing antiviral therapies and the short time - frame in which these agents are effective highlight the critical need for new treatments, such as Eritoran.

«It would be very difficult for the virus to develop resistance against a therapy that targets a cellular protein,» says Palese.

Given that AR - V7 has been associated with resistance to hormone therapy but not chemotherapy, the authors speculated that AR - V7 - positive patients should probably be offered chemotherapy rather than hormone therapy as initial treatment for mCRPC.

«HER3 is thought to be an important mediator of resistance to the HER2 inhibitors class of anti-cancer therapies, which are used to treat HER2 - positive breast cancer representing approximately 20 percent of all breast cancers,» said principal author Eric P. Wehrenberg - Klee, MD, from Massachusetts General Hospital in Boston, Mass. «Imaging of HER3 expression may allow for better understanding of how prevalent HER3 over-expression is among HER2 positive breast cancer patients, which in turn may allow for appropriate patient selection for the addition of HER3 inhibitors currently in clinical development.»

«Given the alarming trend of resistance to our current antimalarial therapies, this is really an exciting finding,» says Dr. Mota, the senior author of the study, «and we are already working to develop Torin molecules suitable for clinical trials of antimalarial activity in humans.»

This work provides direct evidence in mice that cyclin D2 is needed for a successful response to a broad spectrum of insulin resistance, and points toward potential therapies that can be harnessed for preventing and curing type 2 diabetes.

We seek to «Track and Treat» the cancer cells present in patients» tissues by using lineage tracing, as well as sequencing technologies, to determine the molecular mechanisms responsible for the dissemination of cancer cells to various organs, and resistance to current therapies.

The bioinformatics team uses sophisticated algorithms to elucidate markers of response and resistance to therapy, as well as determine how patients can be stratified appropriately for the most relevant therapies under study.»

These models are used for both basic and translational research, including studies to investigate the role of tumor initiating cells in tumor relapse, tumor metastasis and therapy resistance.

We hope CBS - based combination therapy will open up a new horizon for the treatment of infection caused by superbugs, serving as a new and more economical therapy to solve the problem of antimicrobial resistance (AMR).»

World Health Organization Global Plan for Artemisinin Resistance Containment is a call to action that outlines measures to protect the value of artemisinin - based combination therapies for Plasmodium falciparum malaria.

Areas covered by Cancer Cell include, but are not limited to, molecular and cellular mechanisms of cancer, mechanisms for the sensitivity and the resistance to cancer therapies, and development of better cancer therapies.

These results show that acquisition of a JAK inhibitor - resistant mutation such as the Y931C in cells dependent on activated JAK2 V617F for growth is a potential mechanism of secondary resistance to JAK inhibitor therapy in MPN patients.

My studies of cancer genomes have led to characterization of multiple pediatric and adult tumor types, to development of methods that identify and characterize changes in genomic heterogeneity, to defining acquired resistance mechanisms to targeted therapies and to designing novel, personalized vaccines for individual patients.

The broader impact of this finding for this disease is that it provides a relatively noninvasive readout of resistance to PARP inhibitors, and likely to platinum - based agents, and will allow for personalization of therapy based on this readout.

Numerous international publications testify to the research group's commitment to identifying metabolic and molecular pathways as potential targets for innovative therapies that combine nutraceutical intervention and physical exercise, for the prevention and treatment of insulin resistance, of diabetes and associated complications.

These results show that acquisition of a JAK inhibitor resistant mutation such as the F958C in cells dependent on activated JAK1 for growth is a potential mechanism of secondary resistance to JAK inhibitor therapy.

My research efforts are focused on identifying novel combination therapies for breast cancer and the mechanisms that lead to drug resistance.

In 2016, Dmitry I. Gabrilovich, M.D., Ph.D., program leader of Wistar's Translational Tumor Immunology program, and his research team identified a marker for myeloid - derived suppressor cells (MDSCs), a population of immune cells implicated in tumor resistance to various types of cancer treatment, including targeted therapies, chemotherapy and immunotherapy.

This work, and that of colleagues Brian Druker and Novartis, led to the development of the kinase inhibitor imatinib (Gleevec) as primary therapy for chronic myelogenous leukemia (CML), and the discovery that imatinib resistance is caused by BCR - ABL kinase domain mutations.

My go - to herbalist, author and American Herbalist Guild member David Winston of Broadway, New Jersey, says in his book, Herbal Therapy and Supplements: A Scientific and Traditional Approach, that animal and test - tube studies are convincing enough to recommend eating maitake regularly as part of a treatment plan for high cholesterol, high blood pressure, insulin resistance, and even hepatitis B. (Placebo - controlled studies in people have yet to be conducted.)

He's not a huge fan of water but has tolerated our request and done really well in the resistance pool for therapy - it's helping relieve some of the extra stress he puts on the front half of his body and is a fantastic workout for him as he does need to lose a few pounds.

In addition to needless expense for owners, and antibiotics potentially having their own adverse side effects, unnecessary administration of antibiotics may lead to the development of antibiotic resistance which may further complicate therapy in the true «Lyme - ill» patient.

In addition to needless expense for owners, and antibiotics potentially having their own adverse side effects, unnecessary administration of antibiotics may lead to the development of antibiotic resistance which may further complicate therapy in the true «Anaplasma - ill» patient.

Incorrect therapy of urinary tract disease, overuse and misuse of antimicrobials can have negative effects on patient health (e.g. failure to resolve infections), the allocation of resources (e.g. need for repeated or prolonged treatment), and public health (e.g. antimicrobial resistance) and may raise regulatory concerns (e.g. antimicrobial use)[13].

In addition to needless expense for owners, and antibiotics potentially having their own adverse side effects, unnecessary administration of antibiotics may lead to the development of antibiotic resistance which may further complicate therapy in the true «Ehrlichia - ill» patient.

Antimicrobial therapy may need to be continued for up to 2 mo, which may promote emergence of antimicrobial resistance.