Sentences with phrase «for scaffold proteins»

SHANK genes code for scaffold proteins located at the post-synaptic density of glutamatergic synapses.

Not exact matches

Claudio Vita and his colleagues at the protein engineering department of CEA, the French nuclear research agency in Gif - sur - Yvette, are using the toxins found in scorpion venom as a chemical scaffold to build novel proteins for use as drugs (Proceedings of the National Academy of Sciences, vol 92, p 6404).

The group believes that in normal individuals, the prion protein works as a scaffold for multiple molecular interactions.

When prion protein molecules are sequestered by their misfolded counterparts, they can no longer work as a scaffold for all these molecular interactions, which impairs the mechanisms evoked by the brain chemicals important for mood.

This Biotechnology and Biological Sciences Research Council (BBSRC) funded collaborative project between the University of Kent, University College London and the University of Bristol entitled Engineered synthetic scaffolds for organizing proteins within the bacterial cytoplasm is now published in the journal Nature Chemical Biology.

«What the scaffolding proteins do is convert that short memory into something that can last for hours.»

Whereas the team's model proved that the presence of more scaffolding proteins available at the far downstream end of the neuron (and into the synapse) to AMPA receptors increased during LTP, they found the opposite condition for LDP.

With as many as a thousand tubes fitting into each cell, the tubular scaffold can be used to increase the bacteria's efficiency to make commodities and provide the foundation for a new era of cellular protein engineering.

Histones are proteins that serve as a scaffold for coiling up the DNA into the tight space of the nucleus.

Some examples of these nanoscale protein materials are scaffolds to anchor cellular activities, molecular motors to drive physiological events, and capsules for delivering viruses into host cells.

The EB family of proteins helps regulate this process and can act as a scaffold for other proteins involved in pushing the microtubule chain forward.

The nanofibers» structural resemblance to proteins like collagen and elastin found in connective tissue make silk an ideal scaffolding material for vascular grafts and bone / cartilage engineering.

In the first, decel step — short for decellularisation — organs from dead donors are treated with detergents that strip off the soft tissue, leaving just the «scaffold» of the organ, built mainly from the inert protein collagen.

BOND OF LIFE A link between nitrogen and sulfur atoms (bond shown in green) helps hold together protein strands (yellow and white) that create a cellular scaffold essential for tissue and organ formation.

The «parts list» in these processes is similar: Microtubules, semi-rigid tubes of protein, can serve within the cell as scaffolding, roadways, and a building material for machinery; some proteins serve as fasteners, binding and releasing other materials; and motor proteins use chemical energy to push and pull materials along microtubules, or move the microtubules themselves.

A protein that creates a central, spiral scaffold (red links) is partly responsible for the efficient packing, a new study finds.

We hypothesise that a third protein group, the caveolin scaffolding proteins, may provide a link between fibrosis and calcium levels and may be responsible for their disregulation in glaucoma.

They speculate that the normal protein is recruited to the nucleus to provide a supporting scaffold for a construction crew of DNA repair proteins.

A novel role for TPX2 as a scaffold and co-activator protein of the Chromosomal Passenger Complex % U http://www.sciencedirect.com/science/article/pii/S0898656812001295.

PDZ - containing proteins provide a functional postsynaptic scaffold for nicotinic receptors in neurons.

A novel role for TPX2 as a scaffold and co-activator protein of the Chromosomal Passenger Complex.

De novo rational design of molecular scaffolds mimicking protein interactions for specific interference in cell signaling processes: We apply molecular modelling and computer simulation techniques for designing molecules with pharmacological / biotechnological interest.

Our current research focuses on the discovery and functional characterization of novel proteins, the rational engineering of proteins with improved functional properties, and de novo design of molecular scaffolds for a variety of biotechnological and biomedical applications.

The proteins encoded by the most probabilistic sequences at these nodes11 were prepared and used as scaffolds for engineering.

Here, we use resurrected Precambrian proteins as scaffolds for protein engineering and demonstrate that a new active site can be generated through a single hydrophobic - to - ionizable amino acid replacement that generates a partially buried group with perturbed physico - chemical properties.

Repeat proteins are ideal choices for development of such systems as they: (i) possess a relatively simple relationship between sequence, structure and function; (ii) are modular and non-globular in structure; (iii) act as diverse scaffolds for the mediation of a diverse range of protein — protein interactions; and (iv) have been extensively studied and successfully engineered and designed.

It performs a scaffolding role in the post-synaptic density, providing anchorage points for many different proteins, including AMPA receptors.

Tang, Jonathan C.Y., et al. «A nanobody - based system using fluorescent proteins as scaffolds for cell - specific gene manipulation.»

The Meiler laboratory develops technologies to engineer protein, for example through assembly of large protein scaffolds from fragments (Fortenberry, C.; et al.; «Exploring symmetry as an avenue to the computational design of large protein domains»; JACS 2011; 133; 18026 & Eisenbeis, S.; et al.; «Potential of Fragment Recombination for Rational Design of Proteins»; JACS 2012; 134; 4019).

The Steffan laboratory is being funded by the Hereditary Disease Foundation to investigate how the Huntingtin protein interacts with the ubiquitin - tagged trash in order to scaffold it to the lysosome for degradation, and to figure out what kinds of trash may be cleaned up by Huntingtin.

Professional Duties & Responsibilities Biomedical and biotechnology engineer with background in design of biomaterials, biosensors, drug delivery devices, microfrabrication, and tissue engineering Working knowledge of direct cell writing and rapid prototyping Experience fabricating nanocomposite hydrogel scaffolds Proficient in material analysis, mechanical, biochemical, and morphological testing of synthetic and biological materials Extensive experience in bio-imaging processes and procedures Specialized in mammalian, microbial, and viral cell culture Working knowledge of lab techniques and instruments including electrophoresis, chromatography, microscopy, spectroscopy, PCR, Flow cytometery, protein assay, DNA isolation techniques, polymer synthesis and characterization, and synthetic fiber production Developed strong knowledge of FDA, GLP, GMP, GCP, and GDP regulatory requirements Created biocompatible photocurable hydrogels for cell immobilization Formulated cell friendly prepolymer formulation Performed surface modification of nano - particle fillers to enhance their biocompatibility Evaluated cell and biomaterial interaction, cell growth, and proliferation Designed bench - top experiments and protocols to simulate in vivo situations Designed hydrogel based microfluidic prototypes for cell entrapment and cell culture utilizing computer - aided robotic dispenser Determined various mechanical, morphological, and transport properties of photocured hydrogels using Instron, FTIR, EDX, X-ray diffraction, DSC, TGA, and DMA Assessed biocompatibility of hydrogels and physiology of entrapped cells Evaluated intracellular and extracellular reactions of entrapped cells on spatial and temporal scales using optical, confocal, fluorescence, atomic force, and scanning electron microscopies Designed various biochemical assays Developed thermosensitive PET membranes for transdermal drug delivery application using Gamma radiation induced graft co-polymerization of N - isopropyl acylamide and Acrylic acid Characterized grafted co-polymer using various polymer characterization techniques Manipulated lower critical solution temperature of grafted thermosensitive co-polymer Loaded antibiotic on grafted co-polymer and determined drug release profile with temperature Determined biomechanical and biochemical properties of biological gels isolated from marine organisms Analyzed morphological and mechanical properties of metal coated yarns using SEM and Instron Performed analytical work on pharmaceutical formulations using gas and high performance liquid chromatography Performed market research and analysis for medical textile company Developed and implement comprehensive marketing and sales campaign