The strain that the U.S. Food and Drug Administration chose
for the seasonal vaccine did indeed closely match the viruses that sickened people.
Not exact matches
The Centers
for Disease Control and Prevention recommends that everyone 6 months and older get the
seasonal vaccine to protect yourself and those around you.
The Oneida County Health Department announced today that the demand
for seasonal flu
vaccine has been much higher than anticipated and that their supply of
seasonal flu
vaccine was exhausted on October 9th.
«The whole infrastructure required
for the preparation of
seasonal vaccines has enormous disadvantages,» remarks Walter Fiers, a molecular biologist at Ghent University in Belgium.
After its latest battle with H1N1, a U.S. Centers
for Disease Control and Prevention committee recommended in February that everyone six months and older get the annual
vaccine, a step that should improve immunity against future pandemics as well as
seasonal cycles of the flu.
Novavax says that during Phase IIa of
seasonal flu
vaccine testing, which began in May, it was able in the majority of people tested to surpass the FDA's requirements
for producing enough antibodies to protect the body from the H3N2, H1N1 and B viruses — all of which were common enough a year ago to be used to develop flu
vaccines for the 2008 to 2009 flu season.
As the northern hemisphere braces itself
for the flu season, and
for the first time the US recommends flu vaccination
for everyone over 6 months of age, Australia has confirmed that its main
seasonal flu
vaccine, Fluvax, caused convulsions in 99 children, all of whom recovered.
They were randomized to receive one of three
vaccines: the quadrivalent flu
vaccine that contained two A flu strains and both lineages of the B strains; the licensed trivalent intradermal
vaccine for the 2012 - 2013 flu season; or an alternate trivalent intradermal
vaccine that contained two A strains and the B strain that was not in the licensed
seasonal flu
vaccine.
It will enable manufacturers to rapidly create and make available
vaccines for the
seasonal flu and pandemic outbreaks.
«
For the current H3N2, we don't have such studies, so I can't tell you right now the degree the current
seasonal vaccine will protect against the H3N2 virus,» Fukuda says.
If there is such sustained transmission, versus imported cases from people who traveled to areas where the virus is circulating, several decisions would need to be made, Hartl said, including whether to switch production from the
vaccine for seasonal flu to the one
for pandemic flu, and whether to ramp up production of antivirals.
What drives
vaccine fears, he notes, is the knowledge that
vaccines don't work
for everyone and that they can, on rare occasions, cause serious side effects, such as Guillain — Barré syndrome, which develops in one out of every million people who receive the
seasonal influenza
vaccine.
The data obtained from this study provide a basis
for more rapid, cost - effective clinical trials to evaluate new influenza drugs or to determine the efficacy of candidate
vaccines for both
seasonal and pandemic influenza.
Kieny said that
for reasons that aren't fully understood,
vaccine companies that use eggs to grow
vaccine viruses get yields of only 25 % to 50 % of those obtained during the production of
seasonal vaccine.
Last week, the World Health organization reported that
vaccine companies have obtained yields of the pandemic
vaccine that are 50 % to 75 % lower than those
for seasonal flu
vaccine.
No data are yet available
for trials in children, who typically have much less robust immune responses to the
seasonal influenza
vaccine and require a second dose.
Seasonal flu
vaccines may protect individuals not only against the strains of flu they contain but also against many additional types, according to a study published this week in mBio ®, the online open - access journal of the American Society
for Microbiology.
The work, directed by researchers at St. Jude Children's Research Hospital in Memphis, Tenn., found that some study participants who reported receiving flu
vaccines had a strong immune response not only against the
seasonal H3N2 flu strain from 2010, when blood samples were collected
for analysis, but also against flu subtypes never included in any
vaccine formulation.
In addition to introducing more effective
vaccine, India got better at finding high - risk children, homing in on families that move about the country looking
for seasonal work.
«Successful antagonists, following clinical trials
for safety and efficacy, could be incorporated into the
seasonal vaccine as a way of enhancing responses.
«The study by Egli et al. holds promise
for enhancing the response of the
seasonal influenza
vaccine by blocking the receptor used
for the innate immunity signalling molecule IL28B.
Each year, the U.S. Food and Drug Administration, in collaboration with the Centers
for Disease Control and Prevention and the World Health Organization, decides which strains of influenza virus to include in the
seasonal flu
vaccine.
«Confirmation of the protective benefits of the 2012 — 13 influenza
vaccine among persons aged 6 months — 64 years offers further support
for the public health benefit of annual
seasonal influenza vaccination and supports the expansion of vaccination, particularly among younger age groups.