This has been used to create reporters
for second messengers by using protein (domains) that undergo a conformational change upon binding of e.g. Ins (1,4,5,) P3, calcium or cAMP.
Not exact matches
This marks the
second time in four years that the chemistry Nobel has been awarded to someone working with x-ray crystallography; in 2006 Roger Kornberg took the prize
for detailing the structure of
messenger RNA, which is the molecule that carries the information the ribosome uses to build proteins, such as insulin or hemoglobin.
Each such «
second messenger» is a crucial guide
for the cell, helping to determine how the cell responds to the organism's needs
The recent explosion of green fluorescent protein (GFP) based sensors of pH, halides, proteases, kinases, G proteins, and many
second messengers (including Ca2 +, cAMP, cGMP, nitric oxide, and IP3) have provided important tools
for the design of screening assays.
A new cell permeant IP3 antagonist offers a useful tool
for exploring the
second messenger pathway.
Here we show how
second messengers relevant to the Gq signaling pathway can be detected in living cells using assays
for DAG, PIP2, and Ca2 +.
Inositol is a sugar that can serve as a precursor
for a membrane phospholipid (phosphatidylinositol), a
second messenger in signal transduction, an osmolyte, or an energy source.
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