All the technologies
for sequencing the human genome have been developed in this country.
As director of Technology Development, she has helped create methods and automation pipelines
for sequencing the human genome.
His portrait of John E. Sulston, who won the Nobel prize in 2002
for sequencing the human genome on the Human Genome Project, [18] is in the National Portrait Gallery.
Not exact matches
Venter, who is one of the first people to
sequence the
human genome, co-founded the company in effort to discover early genetic markers
for a variety of disorders.
Just last month, the genomic
sequencing company Illumina announced it had developed a
genome sequencer that can map the
human genome for just $ 1,000.
By increasing the speed and accuracy
for NGS data analysis like whole
genome sequencing (WGS), our computing platform makes it easier to discover links between DNA
sequence variations and
human disease.»
Venter explained that when he first
sequenced the
human genome 15 years ago, there was nothing
for him to compare it to.
The, members of the workshop believe that knowledge gained from mapping and
sequencing the
human genome can have great benefit
for human health and well being.
The first
human genome sequence was published the year that Wood began graduate school, providing strong evidence
for evolution.
An international team led by researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) has developed a new technique
for identifying gene enhancers —
sequences of DNA that act to amplify the expression of a specific gene — in the
genomes of
humans and other mammals.
BOSTON —
For bee researchers like May Berenbaum, 2006 was the year an international consortium of researchers published the first full
sequence of the honeybee
genome, offering a unique and long - sought glimpse at the biological quirks of an insect that shares a productive history with
humans.
The man responsible
for one of the original
sequences of the
human genome as well as the team that brought you the first living cell running on
human - made DNA now hopes to harness algae to make everything humanity needs.
Their work has made it increasingly clear that
for all the popular attention devoted to
genome -
sequencing projects, the epigenome is just as critical as DNA to the healthy development of organisms,
humans included.
Now Pääbo and his colleagues have devised a new method of genetic analysis that allowed them to reconstruct the entire Denisovan
genome with nearly all of the
genome sequenced approximately 30 times over akin to what we can do
for modern
humans.
New methods
for the removal of contaminating DNA from microbes and present - day
humans that were developed by the Leipzig group have now enabled the researchers to
sequence the
genomes of five Neandertals from Belgium, France, Croatia, and Russia that are between 39,000 and 47,000 years old.
The luck continued when Viola's colleagues found that the bone contained well - preserved DNA, and they
sequenced its
genome to the same accuracy as that achieved
for contemporary
human genomes (Q. Fu et al.Nature 514, 445 — 449; 2014).
«We explored the opportunity of using sperm RNA elements as a predictor of
human health, with applications at the fertility clinic that would go hand - in - hand with the new neonatal intensive care unit genome sequencing to better health outcomes,» said Dr. Krawetz, associate director of the C.S. Mott Center for Human Growth and Develop
human health, with applications at the fertility clinic that would go hand - in - hand with the new neonatal intensive care unit
genome sequencing to better health outcomes,» said Dr. Krawetz, associate director of the C.S. Mott Center
for Human Growth and Develop
Human Growth and Development.
Using advanced
sequencing technologies, University of Oklahoma anthropologists demonstrate that
human DNA can be significantly enriched from dental calculus (calcified dental plaque) enabling the reconstruction of whole mitochondrial
genomes for maternal ancestry analysis — an alternative to skeletal remains in ancient DNA investigations of
human ancestry.
Encased in ice
for 4,000 years, a clump of prehistoric
human hair gave up its secrets to the University of Copenhagen's Eske Willerslev, the first researcher to
sequence an ancient
human genome.
«Once we can build that sort of database
for the
human organism, it helps us much better understand disease, how to diagnose disease, how better to treat disease,» says Richard Wilson, the director of the
Genome Sequencing Center at Washington University in St. Louis.
The
sequencing of the
human genome has made it possible: nowadays scientists can discover potential disorders
for which there are no known patients.
Over the course of a year, a committee led by Green and Leslie Biesecker, chief of the Genetic Disease Research Branch at the National
Human Genome Research Institute in Bethesda, Maryland, has been weighing how to handle «incidental findings» that turn up when a genome or exome is sequenced for some other medical r
Genome Research Institute in Bethesda, Maryland, has been weighing how to handle «incidental findings» that turn up when a
genome or exome is sequenced for some other medical r
genome or exome is
sequenced for some other medical reason.
The trust now plans to increase its spending from $ 160 million to $ 325 million over 7 years at the Sanger Centre near Cambridge — Britain's main gene
sequencing laboratory —
for more painstaking efforts to
sequence a third of the
human genome by 2005.
The move comes in response to the announcement earlier this week of a new U.S. company, launched by
sequencing - machine manufacturer Perkin - Elmer and J. Craig Venter of The Institute
for Genomic Research, that plans a brute - force approach to
sequencing the
human genome within 3 years (ScienceNOW, 12 May).
«
Sequencing the
human genome, device miniaturization, and the advent of combination devices have shifted the focus from engineering to the life sciences in the device industry,» adds Jules Mitchel, president of Target Health Inc. in New York City, a company that conducts clinical trials
for MD&D companies.
The rationale
for sequencing and exploring the
human genome — to revolutionize the finding of new drugs, diagnostics and vaccines, and to tailor treatments to the genetic make - up of individuals — is the same today.
«This was the ultimate in identity theft,» says Venter, a biologist well known
for his private - sector contribution to the
sequencing of the
human genome.
In the last decade, however, complete
genome -
sequence information and increasingly powerful bioinformatic tools have allowed us to generate and analyse draft interactome maps both
for humans and
for other model organisms.
The
sequencing of the
human genome is gearing up all those efforts, and with each novel model organism
for which the
sequence has been determined, the power of comparative analysis increases.
Work is expected to begin as soon as participants at
genome centers in the United States and abroad agree on some ground rules
for the project, perhaps the most unwieldy collaboration since the
sequencing of the
human genome.
His laboratory develops and deploys new biochemical and computational methods in functional genomics, to elucidate the genetic basis of
human disease and
human physiology, and to create and deploy novel techniques in next - generation
sequencing and algorithms
for tumor evolution,
genome evolution, DNA and RNA modifications, and
genome / epigenome engineering.
«St. Laurent Institute has adapted true single - molecule
sequencing technology to global transcriptome analysis, providing state - of - the - art technology
for the measurement of the output of the
human genome,» said Georges St. Laurent III, Scientific Director of the St. Laurent Institute.
Sequencing the
human genome cost roughly $ 500 million, and essentially all that scientists had to show
for the money was a long string of letters that make up
human DNA.
Hidden in the tangled, repetitious folds of DNA structures called centromeres, researchers from Harvard Medical School and the Broad Institute have discovered the hiding place of 20 million base pairs of genetic
sequence, finding a home
for 10 percent of the DNA that is thought to be missing from the standard reference map of the
human genome.
Just as the
Human Genome Initiative in the 1990s sequenced human DNA for the subsequent identification and analysis of genes, so too will the Materials Genome Initiative sequence materials for identifying new properties for a variety of applicat
Human Genome Initiative in the 1990s
sequenced human DNA for the subsequent identification and analysis of genes, so too will the Materials Genome Initiative sequence materials for identifying new properties for a variety of applicat
human DNA
for the subsequent identification and analysis of genes, so too will the Materials
Genome Initiative
sequence materials
for identifying new properties
for a variety of applications.
As scientists race to decode
genomes — not just of
humans but of bacteria, yeast, chimps, dogs, whales and plants — the number of DNA
sequences available
for analysis has grown 40,000-fold in the past 20 years, providing unprecedented insight into billions of years of species evolution.
The
sequencing of the N. furzeri
genome represents a milestone
for human aging research - since almost all genes of the little fish are also present in
humans.
It may do
for geoscience what
human genome sequencing did
for biology
The research team from the National
Human Genome Research Institute (NHGRI) and the National Cancer Institute (NCI), both parts of NIH, extended their recent genome sequencing study of skin bacteria, using DNA sequencing techniques optimized for identifying
Genome Research Institute (NHGRI) and the National Cancer Institute (NCI), both parts of NIH, extended their recent
genome sequencing study of skin bacteria, using DNA sequencing techniques optimized for identifying
genome sequencing study of skin bacteria, using DNA
sequencing techniques optimized
for identifying fungi.
With the completion of the first phase of the
Human Genome Project in 2000, and the advent of
sequencing technologies that can detect gene variations such as single nucleotide polymorphisms (SNPs),
for the first time scientists have the tools in hand to find the key immune genes and genetic networks that play roles in vaccine response.
The advent of large - scale
genome sequencing has helped scientists identify DNA bacteriophages in the
human gut, skin and blood as well as in the environment, but few researchers have looked
for RNA bacteriophages in those samples.
But the primary
sequences of the
human, mouse, and rat
genomes are also tools from which we can derive the protein
sequence for each gene.
Since the successful
sequencing of the
human genome, interest in the group of genes encoding proteins responsible
for DNA remodeling has grown exponentially.
Evolutionary geneticists Svante Pääbo, Johannes Krause, and colleagues at the Max Planck Institute
for Evolutionary Anthropology in Leipzig, Germany, ground up a 30 - milligram sample and extracted and
sequenced all of the 16,569 base pairs of its mtDNA
genome, using new techniques Pääbo's group has successfully employed to
sequence both Neandertal and prehistoric modern
human DNA.
The researchers were searching
for archaic DNA
sequences in those
human genomes at frequencies much higher than would be expected if those genes weren't doing people any good.
The three centers that pulled down the biggest grants are those with the lion's share of the U.S. contribution to
human genome sequence: Baylor College of Medicine in Houston, the Whitehead Institute
for Biomedical Research in Cambridge, Massachusetts, and Washington University School of Medicine in St. Louis.
The Archon Genomics X PRIZE presented by MEDCO was established in 2006 by the X PRIZE Foundation in Playa Vista, California, to encourage the rapid development of cheap, accurate
human genome sequencing for medical purposes.
The nematode project is also seen as an ideal way of perfecting the mapping and
sequencing strategies researchers will need
for their final assault on the
human genome, which is some 30 times bigger.
When researchers decided to
sequence the
human genome in the late 1990s, they were focused on finding those traditional genes so as to identify all the proteins necessary
for life.
Meanwhile, Illumina, by far the biggest maker of
sequencing machines, is about to introduce a 10 - machine system that can produce 18,000
human genomes per year
for less than $ 1000 a piece.