Sentences with phrase «for signaling proteins»

According to Prof. Holstein, the origin of the first nerve cells depends on the Wnt signal pathway, named for its signal protein, Wnt.

Not exact matches

Protein is hugely important for our body - it aids in muscle repair, speeds up chemical reactions and plays a role in cell signalling.

Protein is responsible for making neurotransmitters, the essential internal messaging service that sends the signals around your body to make it function.

For example, along with these food proteins from egg or cow milk — are there also proinflammatory signals in a mama's breast milk?

«This new study shows a dramatic switching on of the insulin receptor and its downstream signals during the breast's transition to a biofactory that manufactures massive amounts of proteins, fats and carbohydrates for nourishing the newborn baby,» says Dr. Nommsen - Rivers.

Taking a closer look, the team found that the onset of sepsis disrupts the normal activity of specific interferons, signaling proteins used for communication between immune system cells.

β - arrestin, which has several known roles in signaling systems, also links a key receptor to a motor protein so that the receptor can be transported to cilia for sensing environmental cues.

Further study revealed that these so - called immune proteins are actually present on the surface of certain nerve cells, but that they functioned differently in the brain than they did in the rest of the body; rather than scouting for germs, they influenced signals sent between neurons.

Within the framework of research projects of the German Center for Diabetes Research (DZD), scientists of the Research Unit Protein Science (PROT) and the Institute of Experimental Genetics (IEG) at Helmholtz Zentrum München (HMGU) have now investigated how drug treatment affects these signal carriers.

In an additional group of endometriosis samples biopsied from 15 women at the University of British Columbia, the scientists looked specifically for mutations in the KRAS gene, whose expression signals proteins that spur cell growth and replication.

For example, a protein in a cell might start life in the nucleus and then move into the cytoplasm to take part in cell signaling.

Among these was the protein VGLUT1, which is essential for signal transduction in specific nerve cells.

Previous studies have shown that such vulnerability can lead to more frequent anxiety, and anxiety is known to activate a metabolic pathway responsible for the production of pro-inflammatory cytokines, signaling proteins that include interleukin - 6 (IL - 6).

«It is this protein that is responsible for reactivating the growth signal emitted by the HER2 receptor.

In research that has implications for diabetes and other metabolic diseases, an international study based at UT Southwestern Medical Center found that the protein connexin 43 (Cx43) forms cell - to - cell communication channels on the surface of emerging beige fat cells that amplify the signals from those few nerve fibers.

They showed that ZIKV infection of cortical progenitors (stem cells for cortical neurons) controlling neurogenesis triggers a stress in the endoplasmic reticulum (where some of the cellular proteins and lipids are synthetized) in the embryonic brain, inducing signals in response to incorrect protein con - formation (referred to as «unfolded protein response»).

To acquire new insights into the biology and possible therapy of these tumors, Feigin et al. looked for aberrant expression of G protein — coupled receptors, cell signaling proteins that have been successfully targeted for treatment of other disorders such as depression.

Designed for use in spinal fusion surgery of the lower back, Infuse consists of a titanium cage that houses a collagen sponge soaked in bone morphogenetic protein (BMP), a growth factor that signals bone - forming cells to produce new tissue.

In order for newly - produced secretory or membrane proteins to find their final destination, the proteins have signal - sequences connected to themselves as a form of address tag.

For this purpose, proteins have a signal - sequence bound to it that is recognized by other proteins guiding them to their final destination.

The protein Gab2 works like a multi-outlet power strip for proteins in a chain of signals: It can pass on a signal it receives to several enzymes at once and can also amplify the signal.

Gold nanoparticles provide bigger surface area for the affinity interactions between the antibody - antigen and thus enhance the translated signal, while the antifouling molecules help to resist the non-specific adsorption of unwanted proteins from serum onto the transducer surface.

Through their signaling prowess, IDPs help regulate the gas and brake pedals for producing proteins from the DNA code, according to evidence that has accumulated over the past decade, as well as the process by which cells divide.

And, longer - term, misdiagnosing Zika as dengue has another complication: Patients may not be on the lookout for the weakness that could signal the early onset of the associated autoimmune disorder; Guillain — Barré has no cure but there are several therapies they could tap that are known to help speed recovery — involving blood removal or injections of donor proteins.

As important, the greater the compound's bias for G - protein - signaling, the fewer breathing problems it produced in the animals.

Four HCN genes that code for proteins which form ion channels in neurons could be involved, because these channels are vital for electrical signalling in nerves.

Researchers found less evidence for the formation of new blood vessels and fewer protein markers that signal neuroplasticity, or the brain's ability to make new connections between neurons.

And why is it that the relatively small amounts of H2O2 that are produced for signaling are not immediately captured by peroxiredoxins before H2O2 can even react with target proteins?

Now, new research from the Salk Institute shows how a protein called p75 is critical for pain signaling, which could one day have implications for treating neurological disorders as well as trauma such as spinal cord injury.

They chose TMC1 because it is a common cause of genetic deafness, accounting for 4 to 8 percent of cases, and encodes a protein that plays a central role in hearing, helping convert sound into electrical signals that travel to the brain.

The STAT3 protein - it stands for «signal transducer and activator of transcription 3» - is a suspected factor in the relapse of nearly 40 percent of children with AML.

The Pm3 gene is the «blueprint» for a protein that can receive signals in the plant cell, i.e. a receptor.

Since it is known that 13 different members of the fibroblast growth factor, or Fgf, family act as signaling proteins between the two different tissues — dental mesenchyme and oral epithelium — during murine tooth development, Javed and colleagues looked for changes in Fgf ligands in the mice lacking Sp7.

The signal for this destruction turned out to be the buildup of proteins that were misfolded because of the stress.»

Then there's the West Palm Beach symposium, held to recruit participants for a study testing what happens when aging people get infusions of plasma (the fluid part of blood packed with signaling proteins and other molecules but no red or white cells) from young people who've taken a drug meant to activate their immune system.

«Discovering that these protein interact with other signals in preformed complexes gives us more precise targets for medication development.»

Scaffold proteins offer a simple, flexible strategy for regulating selectivity in pathways, shaping output behaviors, and achieving new responses from preexisting signaling components.

«This is the first time that this specific protein - protein signaling complex has been identified in GBM, and it gives us a new potential target for drug development,» says Fisher, Thelma Newmeyer Corman Endowed Chair in Cancer Research and co-leader of the Cancer Molecular Genetics research program at VCU Massey, professor and chair of the Department of Human and Molecular Genetics at the VCU School of Medicine, and director of the VIMM.

Researchers from UT Southwestern's Charles and Jane Pak Center for Mineral Metabolism and Clinical Research and Internal Medicine's Division of Nephrology recently published work in Nature that reveals the molecular structure of the so - called «anti-aging» protein alpha Klotho (a-Klotho) and how it transmits a hormonal signal that controls a variety of biologic processes.

The addition of many ubiquitin molecules can target a protein for degradation, while the addition of a single ubiquitin molecule (monoubiquitination) can lead to activation of protein signaling pathways or target other proteins for ubiquitination.

For the study, the Bohn worked closely with TSRI chemist Thomas Bannister, PhD, to develope new potential drug molecules; they then tweaked their chemical structures to systematically vary the «bias» between the two pathways — G protein signaling and beta - arrestin recruitment.

They then selected six compounds to represent a wide range in the degree of bias (from those that preferred barrestin2 recruitment to those that almost exclusively preferred G protein signaling) and determined their overall potency for inducing analgesia and respiratory suppression in mouse models.

Hong - Zhong Zhang and colleagues at the University of California at San Francisco deciphered the signaling system between a protein in a resistant staph cell that keeps watch for beta - lactams and a second protein that it tells to turn on the gene for beta - lactamase when the drugs are present.

Patients who received the DNA for 12 weeks apparently made altered proinsulin proteins that signal the immune system to rein in the rogue T cells.

The researchers found that C. mast, when cultured with immune cells from the conjunctiva, induced the production of interleukin (IL)-17, a signaling protein critical for host defense.

«The computational approach allows us to model, right down to the atomic level, how small changes in protein sequence can have a major impact on signaling,» said MacDermaid, assistant professor of research at Temple's Institute for Computational Molecular Science.

The researchers wanted to know which signals in the brain were responsible for building long - term memory and for forming the special proteins involved.

In many sequences, the normally continuous code for translating the DNA sequence into protein had been disrupted by a stop - codon, a signal to end translation.

For example, Capsaspora activated transcription factors and a tyrosine - kinase signaling system in different stages to regulate protein formation.

In the absence of that protein, other proteins involved in transmitting signals between neurons in the brain are overproduced, notably mGluR5, a receptor for the neurotransmitter glutamate.