Sentences with phrase «for smaller tumors»

It provides a better target for biopsies, especially for smaller tumors,» said Rebecca Rakow - Penner, MD, PhD, a research resident in the Department of Radiology and the study's first author.

The proportion of failed breast conservation surgery in these hospitals ranged from 3 - 32 %, while the proportion of mastectomies for small tumors ranged from 0 - 60 %.

If possible, surgery is often the treatment of choice for small tumors, particularly those located in the front of the lower jaw.

Not exact matches

The targeted radiotherapy shrank tumors for 71 % of patients who had already failed standard chemotherapy, but these results came from a small trial that started with 30 patients and then added another 20 after positive data started rolling in.

This tube can be squeezed shut or blocked — for example, by a tumor or a gallstone — which prevents the bile from entering the small intestine.

Researchers targeting a small subset of tumor markers would end up paying for extra controls they didn't need.

«Even when an entire tumor has been removed, it is common for a small number of tumor cells to remain behind.

«Particularly in such patients with underlying CKD, our modeling results support the integration of renal tumor anatomic features at cross-sectional imaging into decision making for treatment of small renal masses and may be used to provide a patient - centered framework for selection of optimal candidates for ablative therapy,» Kang said.

Led by Stella K. Kang, a radiologist with the Department of Radiology at the New York School of Medicine, the study was designed to compare the effectiveness of a treatment algorithm for small renal tumors incorporating the nephrometry score, a renal tumor anatomy scoring system developed by urologists, with the current standard of uniformly recommended partial nephrectomy in patients with mild - to - moderate chronic kidney disease (CKD).

Small populations of adult stem cells with somewhat limited developmental potential are responsible for the body's ability to heal injuries and replace worn out cells and tissues, and evidence is growing that rare cancer stem cells are responsible for the uncontrolled growth of some malignant tumors, including glioblastoma.

The activity of four transcription factors — proteins that regulate the expression of other genes — appears to distinguish the small proportion of glioblastoma cells responsible for the aggressiveness and treatment resistance of the deadly brain tumor.

In the last few years, a bulk of data pointing to a small population of cells in tumors that maintain tumor growth, are particularly resistant to chemotherapy, are responsible for relapses, and develop metastases.

Tumor biopsy is often impossible for early cancer diagnosis as the developing tumor is too small to see by the current imaging tTumor biopsy is often impossible for early cancer diagnosis as the developing tumor is too small to see by the current imaging ttumor is too small to see by the current imaging tools.

Constructing a complete map of all of the genetic variation within even a small tumor, for example, would require sequencing trillions of single cells.

«We wanted to utilize platelets» intrinsic tendencies to accumulate at wounds and to interact with circulating tumor cells, for targeted delivery of immune checkpoint inhibitors» said Gu, «Interestingly, we found the antibody can be promoted to release from activated platelets in the surgical site, due to generation of small platelet - derived microparticles upon the platelet activation.

According to Semenza, «Chemotherapy may kill more than 99 percent of the cancer cells in a tumor but fail to kill a small population of cancer stem cells that are responsible for subsequent cancer relapse and metastasis.»

CLI's high - resolution and small - sized imaging equipment make it a promising technology for assessing tumor margins during breast tumor surgery.

Weisman said it should be possible to noninvasively find small ovarian tumors within rodents used for medical research by linking nanotubes to antibody biomarkers and administering the biomarkers intravenously.

1 in 5: And even though you're a lot less likely to die of breast cancer these days, a New England Journal of Medicine article contends that we're pulling the trigger too early on treatment: For every one case of a small tumor caught early that would have been a health threat, about five essentially harmless tumors also receive the same treatment.

Tumors that are smaller than 2 centimeters and haven't metastasized are considered the best cases for surgery.

Most of the cells that made up the tumors were positive for CA125, but the researchers found a small population that were negative and focused on those, Janzen said.

Researchers were able to complete the first genome - wide screen of a mouse by injecting small hairpin RNAs into the embryos of 100 pregnant mice and analyzing the animals after birth to look for genes that contributed to tumor growth.

If a small tumor can release enough DNA into the plasma of a patient for us to detect it, maybe a seven - pound baby could do the same.»

Dr Jeremy Thomas, a consultant pathologist at the Western General Hospital, Edinburgh, UK, told the European Breast Cancer Conference that although the majority of women with DCIS received the correct surgery for their disease, large numbers of women were undergoing mastectomy for DCIS either as a result of failed breast conservation surgery or for tumors that turned out to be smaller than 20 mm in diameter and therefore should normally have had a lumpectomy rather than a mastectomy.

The total number of women who had mastectomies, including those for whom mastectomy was the first course of action as well as those who had failed breast conservation, was 2,479; of these, 510 (21 %) had mastectomies for tumors smaller than 20 mm in diameter, which would normally have been better treated with a lumpectomy.

While circulating tumor DNA tests targeting a smaller set of cancer genes are already available for use in routine practice to guide care, by covering a much larger number of cancer genes, this high - intensity sequencing approach may enable development of future tests for early detection of cancer.

But scientists have struggled for years to harness the small number of T cells, the immune system's first line of defense, that are thought to fight these tumors.

«The biggest surprise was that a small amount of copper added to drinking water accelerated the growth of tumors, indicating that copper is an essential nutrient for them, said Ishida.

About 20 % of breast cancers are inherited, but the known susceptibility genes account for just a small portion of these breast tumors.

However, about 10 percent of them are common across multiple cancers, suggesting that a relatively small number of therapies targeting these core dependencies might each hold promise for combatting several tumors.

Moreover, tumors contain a small portion of cancer stem cells that are believed to be responsible for tumor initiation, metastasis and drug resistance.

Finding cancer early can improve a patient's chances for survival, but small tumors can be difficult to see with scanning techniques such as magnetic resonance...

Levels of a small non-coding RNA molecule called let - 7 appear to define different stages of cancer better than some of the «classical» markers for tumor progression, researchers from the University of Chicago report in the June 25, 2007, early online edition of the Proceedings of the National Academy of Sciences.

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Unlike previous MRI studies of tumors in mice, the researchers were able to detect very small naturally occurring cancers, which were excellent models for human breast cancer; the tumors the mice developed were «realistic models of the most frequently detected human cancers,» the authors wrote.

Rather, each tumor contains a small subset of cells with stem cell - like capacities that are responsible for initiating and sustaining tumor growth, while the bulk of the tumor cells lacks this ability.

When they blocked IKK2 activity in the mice with lung cancer, the mice had smaller tumors and lived longer, suggesting that the enzyme is necessary for NF - KB to stimulate tumor growth.

The mission of the Institute for Applied Cancer Science (IACS) is to apply scientific knowledge of mechanisms driving tumor development and maintenance into the development of impactful small molecule cancer therapies.

An initial five - year, multicenter study of cryoablation to treat early - stage breast cancer sponsored by the National Cancer Institute found it to be 92 percent effective for complete ablation of invasive breast tumors smaller than 2 centimeters and 100 percent effective for complete ablation of invasive ductal breast cancer tumors smaller than 1 centimeter.

A biopsy to confirm the diagnosis is performed by removing a small piece of tissue from the tumor for examination under a microscope.

Orders of magnitude more sensitive than conventional Raman microscopy, they allow mapping of 3D distributions of small molecules, such as metabolites and drugs, as well as tumor identification in tissues, which open many exciting new possibilities for biology and medicine.

The long - term goal is to develop strategies for two therapies, one for eliminating the bulk of the tumor, the other for small subpopulations that escape all major therapeutic strategies.

This is to accommodate small variants that occur at sites of copy number variation as well as in samples that are not pure: for example, due to tumor heterogeneity or sample mosaicism.

The appetite of cancer cells for glucose is so great that it can be used to identify small groups of tumor cells that have spread throughout the body.

Dangerous brain tumors hijack the brain's existing blood supply throughout their progression, by growing only within narrow potential spaces between and along the brain's thousands of small blood vessels, new research shows for the first time.

The growth of new blood vessels tends to occur quite early for most cancers; even small tumors found via mammogram frequently have a high microvessel count (MVC).

The company's lead candidate, GLN - 1001, is a first - in - class, orally available oncolytic small molecule, currently being developed as a potentially disease modifying therapy for glioblastoma by targeting specific vulnerabilities in tumor cells.

The use of such a high - energy proton beam is ideal for imaging small tumors within patients for targeted proton therapy.

Cryoablation — killing cancer cells with extreme cold — is a promising treatment for small, early - stage breast tumors.

In tumor samples, where we frequently encounter variants with a very small allele frequency due to contamination with normal tissue, copy number variation, and tumor heterogeneity, high coverage is essential for accurate detection of these variants with high power.