Sentences with phrase «for specific cell types»

«The challenge has been how to direct certain therapies designed to manipulate genes of interest in specific cells without developing a specific drug carrier for each specific cell type.

Not exact matches

Because every cell type in a mammalian organism requires access to genomic areas in a tempo - spatial specific manner, the epigenome is crucial for determining cellular identity.

«This is exactly the technology you could use to look for epigenomic changes in specific cell types,» says Martienssen, who is also on the International Human Epigenome Consortium's steering committee.

«Only by understanding the complexities of what happens in specific cell - types found in specific areas of the brain during this disease can targeted treatments for Parkinson's disease be produced.»

One of the many mysteries of stem cells is how they morph from a universal cell type, full of possibility, into one that's tailored for a specific job.

Scientists are hopeful that ultimately these cells could be transformed in the laboratory to yield specific cell types needed for a particular treatment, or to cross the «blood - brain barrier» by expressing specific therapeutic agents that are released directly into the brain.

«We've shown that a specific type of these cells, known as follicular helper T (Tfh) cells are not only necessary, but are a limiting factor that differentiates between an average and a potent antibody response to HIV,» says Crotty, a scientific collaborator with the Center for HIV / AIDS Vaccine Immunology & Immunogen Discovery (CHAVI - ID), a major research consortium led by The Scripps Research Institute.

To better determine the role of specific chemoattractants in type III hypersensitivity, lead author Yoshishige Miyabe, MD, PhD, a research fellow in Luster's lab, used multiphoton intravital microscopy — an imaging technology pioneered for studies of immune cell movements in living animals by CIID investigator and co-author Thorsten Mempel, MD, PhD — to follow in real time the development of IC - induced arthritis in a mouse model of rheumatoid arthritis.

In a previous related study published in the Journal of Materials Science: Materials in Medicine, the same team of NTU scientists found that fish scale - derived collagen would induce human umbilical vein endothelial cells to express 2.5 times more of a specific type of collagen responsible for blood vessel formation, as compared to endothelial cells cultured on bovine collagen.

The transplanted stem cells differentiated to different types of cells with variable level of maturation, specific for the nervous system.

All stem cells are immature cells known for their ability to multiply indefinitely and give rise to progenitor cells that mature into specific cell types that populate the body's tissues during embryonic development.

We hope that this tool will help researchers gain new biological insights from transcriptome datasets in the future and provide information for diseases that affect specific cell types.»

The sorting of individual cells is necessary for many biological applications, including the isolation of specific cell types from cell suspensions.

While the genetic code carried in our DNA provides instructions for cells to manufacture specific proteins, it is a second code that determines which genes are in fact activated in particular cell types.

«Use of induced pluripotent stem cell (iPSC) technology» — which involves taking skin cells from patients and reprogramming them into embryonic - like stem cells capable of turning into other specific cell types relevant for studying a particular disease — «makes it possible to model dementias that affect people later in life,» says senior study author Catherine Verfaillie of KU Leuven.

«Not only did we find that LIGHT expression promoted tumor regression, upon further study we also identified the specific type of T - cell — CD8 — that was responsible for shrinking the tumor,» Maker said.

The specific pattern of epigenetic marks in a cell type specifies identity and this epigenetic control is vital to what makes our cells different, for example a skin cell from a liver cell, when they all contain the same genetic instructions.

LPA is produced by a specific type of stromal cells, which forms a scaffold for lymphocytes to crawl around within the node.

The technique, named cell type specific labeling using amino acid precursors (CTAP), exploits the inability of vertebrate cells to synthesize essential amino acids normally required for growth and homeostasis.

For example, how genetic programs affect the function of specific cell types, how they vary early or later in life and how dysfunction in these programs might contribute to disease, all of which could help scientists learn more about the fundamental workings of the brain.

Furthermore, besides offering valuable insight into the function of this novel RNA type, the researchers also believe that the findings will open new avenues for novel treatments in which cell - specific enhancer sequences can be targeted to alter gene expression.

«We hope this atlas will be a roadmap for the field to explore the relationship between specific cell types, signaling pathways, receptors, and the physiological function of brain circuits,» Kriegstein added.

This finding suggests their approach could be tailored to generate specific cell types for patients with different types of hypopituitarism.

Currently, investigators around the world are experimenting with restoring the immune cells responsible for keeping CMV in check by transplanting those specific anti-viral cells from healthy donors — a type of immunotherapy.

Different types of tumors show a preference for specific organs and tissues; circulating breast cancer cells, for example, are likely to take root in bones, lungs, and the brain.

Previously, in the region that controls the function of the transcription factor that promotes differentiation from ES cells to a specific cell type, bivalent modifications of histones such as the accelerator and brake histone marks for transcription were thought to have coexisted.

«Our findings are important because knowing the location and specific cell type that require Jagged expression gives us the information we need to target therapeutics to the right place to compensate for the lack of Jagged function in Alagille syndrome,» says Dong.

Solt notes that the study strongly suggests that Th17 cells have a pathological role in the development of type 1 diabetes and use of ROR - specific synthetic compounds targeting this cell type may have potential as a preventative therapy for type 1 diabetes.

We're manipulating genes in the cell nucleus to produce specific proteins, changing the normal recipe for growth and maturation, and transforming adult cells into a new type of cell with the ability to morph into any other cell type,» said Cooke, senior author and chair of the Department of Cardiovascular Sciences.

«A better understanding of the brain region and cell type - specific binding targets of Hnrnph1 will tell us more about the function of this gene and possibly identify new therapeutic strategies for minimizing risk and treating psychostimulant addiction — a disorder for which there is currently no FDA - approved drug,» explained corresponding author Camron Bryant, PhD, assistant professor of Pharmacology and Experimental Therapeutics & Psychiatry at BUSM.

CHiP - Seq data show that cell - type - specific promoters are enriched for cell - type - specific transcription factors.

Although scientists have examined insulin action in tumors for years, the ability to knock out the insulin receptor in specific types of tumor cells adds a level of sophistication to these investigations, Rask - Madsen emphasizes.

While it is generally accepted that MSC are mostly quiescent during postnatal life, MSCs in different niches can presumably differentiate into the specific cells of closely related niches during physiological turnover, injury or disease, as shown for other stem cell types (e.g., muscle satellite cells).

In this edition, we're going to take a look at a very interesting tool that can be used for creating (excuse the pun) specific, targeted DNA modifications in transgenic animals, embryonic stem cells, and / or tissue - specific cell types: Cre - lox recombination.

In particular, they are now looking for expertise in molecular biology, especially in virus - based techniques for introducing new genes into specific cell types in the grid - cell circuit.

Ng2 - Cre is known to be expressed in the male germline, which needs to be considered in using Ng2 - Cre mice for cell type - specific conditional mutagenesis experiments, but the germline expression of Pdgfrb - Cre in both sexes limits the use of Pdgfrb - Cre as deleter for pericyte - related experiments.

Depending on the composition of the viral envelope, viruses exhibit particular patterns of cell tropism, and thus are suited for infecting specific cell types.

By understanding how certain brain cells are either vulnerable or resistant to neurodegenerative diseases, the lab has also discovered specific «profiles» of vulnerable cell types, thus advancing neuroprotective strategies for Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis (ALS).

With the recent development of transgenic mouse models, which allow labelling and manipulation of specific cell types, more and more emphasis has been placed on the tissue scale: How does the collective behavior of many cells gives rise to the architecture that is characteristic for given kind of tissue?

Specific emphasis will be given to various microfluidic designs targeted for use with different cell types.

In doing so, specific cell types may activate immune responses to fine tune cell - fate decisions at the organismal level; for instance, DNA damage in germ cells induces an innate immune response in worms that promotes endurance of somatic tissues to allow delay of progeny production when germ cells are hit by DNA damage.

The system, originally developed in 2007 and refined by Wall and Callaway for targeting specific cell types in 2010, uses a modified version of the rabies virus to «infect» a brain region, which in turn targets neurons that are connected to it.

During development, cells have to integrate different types of molecular and physical information to proliferate, and to make decisions such as whether to maintain pluripotency or trigger differentiation and acquire specialisation for tissue - specific functions.

However, the further development this type of therapy requires a reliable source for the large amounts of homogenous functional patient - specific NK cells needed and this has led to the generation of NK cells from human induced pluripotent stem cells (iPSCs)[3].

ENCODE has laid a foundation for these kinds of studies by examining more than 140 of the hundreds of cell types found in the human body and identifying many of the cell type - specific control elements.

To define the relationship between neuropeptide signaling and aging, we are developing novel approaches for cell - type - specific analysis of neuropeptide signaling in the worm and the mouse.

Ultimately, we use all this information to establish innovative culture techniques for generating unlimited neural stem cell sources for the derivation of specific types of clinically relevant neuronal or glial cells, for their use in disease modelling and drug discovery platforms, and towards refining their efficacy for future cell replacement - based therapy.

Generation of mouse models for cell type - specific manipulation of translation, tools to visualize de novo protein synthesis, and techniques to identify translating mRNAs and newly synthesized proteins

Zoghbi has also investigated the cell type - specific requirements for MECP2, and recently discovered that restoring MECP2 levels in certain neuronal subsets can rescue Rett phenotypes in mouse models.

September 1, 1997 Targeting gene therapy to specific cells Researchers at the University of Chicago Medical Center have developed the first practical method to restrict the activity of genes used for gene therapy to a specific cell type.