Sentences with phrase «for stem cell maintenance»

However piwi, while expressed in both somatic and germline cells, is required in the terminal filament for stem cell maintenance but is also needed for cell division in the germline.

While scientists have long known that a group of transcription factors are needed for stem cell maintenance, the sheer number of possible interactions among them has made the question of which are essential too complicated to address in the laboratory alone.

Not exact matches

While some previous studies found that maintenance lenalidomide after autologous hematopoietic stem cell transplant improved overall survival for newly diagnosed multiple myeloma patients, others showed no benefit to this approach.

For this analysis, 605 patients with newly diagnosed multiple myeloma and treated with continuous lenalidomide (brand name Revlimid) following autologous stem cell transplant were compared to 604 patients who were treated with placebo or no maintenance.

«Lenalidomide maintenance following autologous stem cell transplant can now be considered a standard of care for people with multiple myeloma,» says Dr. McCarthy, senior author on the meta - analysis and Principal Investigator of the U.S. study, CALGB (Alliance) 100104.

«By analyzing mice with the WNT10A mutation, as well as tissues from human patients with WNT10A mutations, we found that WNT10A regulates the proliferation, but not the maintenance, of stem cells in hair follicles,» said Sarah Millar, PhD, vice chair for Basic Research in the Department of Dermatology.

BPTF, identified by Dos Santos and colleagues as essential for mammary stem cell maintenance, is a protein with a very specialized function.

Kruppel - like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion

«Additionally, these findings point to a promising strategy for delivering stem cells to targeted niches for their long - term maintenance and generation of functional cells through augmented stem cell competition.»

Researchers have demonstrated that the enzymatic activity of R5 receptor - type protein tyrosine phosphatases is a requisite for the maintenance of stem cell properties and tumorigenicity in glioblastoma cells and could be a promising drug target for treatment.

Regina Duryagina (Bornhäuser, TUD)-- «Role of Jagged - 1 and extracellular matrix components for the maintenance of hematopoietic stem and progenitor cells during ex-vivo expansion» (2013)

Further phenotypic characterization revealed that LKB1 is required for the differentiation and maintenance of two NCC - derivatives, Schwann cells and the ENS. Using a model of neural crest stem cell line, we demonstrated that Lkb1 is key for neural crest - derived glial commitment.

Arndt K, Grinenko T, Mende N, Reichert D, Portz M, Ripich T, Carmeliet P, Corbeil D, Waskow C. CD133 is a modifier of hematopoietic progenitor frequencies but is dispensable for the maintenance of mouse hematopoietic stem cells.

A lot is known about the transcription factors important for self - renewal and maintenance of neural stem cells, but drugging these is notoriously difficult.

«We hope this research will help inform clinicians into congenital defects related to the formation and maintenance of arteries and veins, and may also yield new strategies that can coax the development of arteries from stem cells — which may prove useful for treating coronary artery disease.»

Adult stem cells serve as a reservoir of cells for repair of damaged tissue throughout the life of an individual, but the maintenance and regeneration of tissues, such as skin, liver, blood and muscle, dramatically decrease with age.

Adult stem cells are essential for the maintenance and regeneration of organs and tissue.

Studies have identified transcription factors such as Stat3, Nanog, and Oct4 as being necessary for embryonic stem (ES) cell self - renewal and maintenance of pluripotency.