Sentences with phrase «for subsets of genes»

(C — F) For a subset of genes (Table S1), the log10 normalized intensity values obtained from the microarrays (C — D) and from RNAseq in FPKM (E — F) are plotted against the log10 RQ values from TaqMan qRT - PCR assays.

Not exact matches

Using a novel combination of technologies, including trio exome sequencing of patient / parental DNA and genetic studies in the tiny larvae of zebrafish, the EuroEPINOMICS RES consortium found that mutations in the gene CHD2 are responsible for a subset of epilepsy patients with symptoms similar to Dravet syndrome — a severe form of childhood epilepsy that is in many patients resistant to currently available anti-epileptic drugs.

The discovery of CHD2 as the culprit gene in a subset of children with epileptic encephalopathy is a major step for us.»

Single - cell differential gene expression analysis revealed a spectrum of known transcripts, including several linked to cytotoxic and costimulatory function that are expressed at higher levels in the TEMRA (effector memory T cells expressing CD45RA) subset, which is highly enriched for CD4 - CTLs, compared with CD4 + T cells in the central memory (TCM) and effector memory (TEM) subsets.

They have also looked for the activity of similar genes in the silk glands and other tissues of cobweb - weaving spiders, a subset of orb weavers that build 3D webs instead of flat ones.

In order for these unspecialized cells to acquire the characteristics that make a leaf cell different from a root cell or a blood cell different from a muscle cell, they must turn on different subsets of genes to produce the proteins responsible for each cell type's distinctive properties.

Each rattlesnake lineage has deleted two to four entire venom genes compared to their common ancestor, while retaining the genes for only a subset of venom types.

They hope to identify the complete set of DNA binding sites and corresponding target genes for the regulons in embryonic stem cells and a subset of the cells they differentiate into.

Second, the AAV preps generally used for gene editing are low titre, and are therefore able to infect only a small subset of the cells used in a given experiment.

Systemic vs. mucosal immunisation regimens will be compared for optimal induction of innate and adaptive immune cell subsets, including Th1, Th2, Th17, Th22 and regulatory T cells, as well as inflammation genes.

Our laboratory has assembled a comprehensive set of tools for doing this, including mice with conditional ablation of the Btla gene in different subsets of immune cells.

Not content to provide just the missing evidence for a 60 - year - old puzzle, Wilhelm and his colleagues went on to describe what a subset of these genes do in C. elegans and how they might be driving the ageing process.

In light of this, homology - based methods of functional gene annotation will be suitable for only a subset of the genome.

In concurrent studies, the team will examine the gene expression profile of subsets of patients with different clinical outcomes to provide further insight into why certain dogs have more aggressive B - CLL and to identify possible drug targetable pathways to improve the treatment for this cancer.

The Scottish and West Highland White terriers and the Shetland sheepdog are at high risk for TCC, suggesting that subsets of dogs from each of these breeds are born with errors in critical genes that predispose them to TCC.

A subset of this matrix was combined with sequences from rbcL, atpB, and 18S rDNA to provide a four - gene matrix for 26 genera of Caryophyllales.