Sentences with phrase «for switching genes»

Not exact matches

Gene, Gene the Coke Machine (that's Coke as in soda pop) is the team's moniker for the 6» 3», 280 - pound Chilton, who's being switched from tackle to center, where he'll anchor an offensive line that lost four of five starters, not counting both tight ends.

«Some people are protected from the effects of sleep deprivation by this particular gene variation but, for most of us, sleep loss does something to the brain that simply prevents us from switching gears when circumstances change.»

«Regulatory RNA modules are attractive for applications in synthetic biology, because they detect signals from the environment directly and instantly switch the subsequent genes on or off,» explains Johanna Roßmanith.

Tsai's group manipulated the gene for the protein p25, which has been implicated in several neurodegenerative diseases, so that it could be easily switched on and off.

This finding came as a surprise since it was assumed that as a consequence of the evolutionary divergence between human and other animal viruses, the genes that code for LANA could not be switched.

The study, published online today in Science Translational Medicine, further points to a master switch for these gene sets as a potential target of future therapies.

A virus containing the gene that codes for two molecular «switches» essential for turning skin cells into brown fat was used to trigger the change (Nature, DOI: 10.1038 / nature08262).

The key insight for building such drugs came to Tim Tully, founder and chief science officer of Helicon, when his team at Cold Spring Harbor Laboratory on Long Island stumbled upon the molecular switch: a gene called CREB, which is involved in converting short - term memories into long - term ones.

Working with this hypothesis, the researchers conducted a statistical analysis of the CX3CR1 gene in over 7000 schizophrenia and autism patients and healthy subjects, finding one mutant candidate, a single amino acid switch from alanine to threonine, as a candidate marker for prediction.

CBX2 has aroused interest as a possible master switch for maleness because tests in human cells suggest that mutations in it can shut off a gene on the Y chromosome critical for male sexual development.

The team concludes that the acetyl cap acts as an «on» switch for the crucial genes.

She also sought out genes that controlled the switch for maturation of T helper cells, maintaining just the right balance of T helpers — between Th1 cells that suppress allergic responses and Th2 cells that trigger them.

Harris and Ratcliffe describe in this month's Nature Genetics (vol 2, p 515) how the switch system might be used in gene therapy for cancers.

Researchers are developing molecular switches that can inactivate transplanted genes, paving the way for safer gene therapies.

Affected family members, the group found, had inherited one or two defective copies of ZIC3, a previously unknown gene that appears to code for a transcription factor — a protein that switches other genes on or off.

This test determined that only a few genes switched off when signaling was blocked — and one of them was the gene known to code for MHCI.

Issued last March to researchers at a little - known cotton seed company called Delta & Pine Land (D&PL) and the U.S. Department of Agriculture, the patent covers a technique for transferring three genes along with their genetic on switches into the seeds of genetically improved plants.

In these animals, they switched off the gene responsible for producing the enzyme arylsulfatase G.

This technique was inspired by evidence that cancers grow like embryos do, re-awakening many genes vital for rapid growth during pregnancy that had been switched off after birth.

For instance, alterations to these chemical switches can change the architecture of the heterochromatin, causing genes to be expressed or silenced.

Using previous data, Orkin and his team identified the BCL11A gene as a candidate for controlling the molecular switch.

The two genes implicated — GNAQ and GNA11 — code for proteins (known as G proteins) that normally function as molecular on - off switches, regulating the passage of information from the outside to the inside of a cell.

Some RNA molecules switch genes on and off, for example, whereas others bind to proteins and other molecules.

Making up 98 percent of the genome, these regions do not code for proteins, but they contain «switches» that like a conductor control when and where genes are expressed.

Still, by identifying the human hairless gene as an important master switch in regulating cell death in a hair follicle — a discovery that could lead to gene therapies for unwanted hair growth — Christiano emerged as a new star in the field, and a glamorous one.

Within the duplicate regions, Carmona - Mora and her colleagues discovered many switches, known as enhancers, important for controlling activity of genes.

For example, nuclear factor - kappa B (NF - kB) is a complex of proteins that acts as a master switch for turning inflammation genes on and for controlling cell deaFor example, nuclear factor - kappa B (NF - kB) is a complex of proteins that acts as a master switch for turning inflammation genes on and for controlling cell deafor turning inflammation genes on and for controlling cell deafor controlling cell death.

«We knew that Smchd1 was an epigenetic suppressor — a factor that switches off genes that are unnecessary for that particular cells» function — but we were in the dark about where and how it was acting on the DNA.»

What we were surprised to find out was that the real differences we could detect in terms of when we did the swap experiments to say which yeast could outperform the other — what we learned was that the GAL1 gene, that the part [of] that, the DNA sequence is outside of the GAL1 gene, it acts as a switch to turn up or turn down GAL1 expression, that had evolved considerably from the ancestral situation; and same for the GAL3.And then what had happened was that each function had been optimized, that GAL3 had sort have been tuned to be sort of a loosely regulated kind of available anytime sensor of galactose and GAL1 had evolved to be an incredibly tightly regulated, in fact, it's the most tightly regulated gene you know of in yeast.

Akassoglou and her colleagues thought they had a good candidate in the gene for the p75 neurotrophin receptor (p75NTR), a regulator of cell death in the brain that also switches on soon after liver injuries.

In DIPG, this «on» switch for gene expression replaces methylation, or a protective «off» switch for cancer - causing genes.

To see if the gene, Gp - 9, was really a switch for social behavior, the researchers raised fire ants in captivity.

For all 20,000 individual genes, they determined whether those genes were heritable — controlled by the DNA «dimmer switch» — or largely affected by environment.

The scientists zeroed in on the cells from the hippocampi of the cadavers, examining the switch for the stress hormone gene they had studied in rats.

Researchers showed that the genes turned on by the switch remained active for several hours in several mammalian cell lines even after a short light pulse.

The team studied the genomes of almost 8,000 child and parent trios, focusing on genes that coded for proteins as well as non-coding parts of the genome that control the switching on and off of genes, known as regulatory elements.

The researchers engineered a strain in which a Synechococcus gene normally turned on during photosynthesis signals its activity by switching on the gene for luciferase, an enzyme from another bacterium that drives a light - emitting chemical reaction.

The advances even point to strategies for exploiting these regulatory elements to treat disease, by switching off disease genes and turning up the activity of healthy ones.

Think of these promoter regions like on - off switches for next - door genes — when a promoter region is methylated, the switch is turned off and the gene it controls does not get read and expressed.

«Cell biologists discover on - off switch for key stem cell gene.»

Boston Children's Hospital has offered non-exclusive licenses to for - profit entities on a patent developed by Orkin's laboratory regarding BCL11A, a genetic switch regulating hemoglobin production that is expected to form the basis of clinical trials for gene therapy and gene editing for sickle cell disease and thalassemia.

They then used genome - wide analysis to search for genes switched on by KLF4 at a late stage of reprogramming.

MicroRNAs are short molecules that work within all animal and plant cells, typically functioning as a «dimmer switch» for one or more genes, binding to the transcripts of those genes and preventing protein production.

What makes a horse different from a tiger, a mouse and a walrus is the set of regulatory switches in the DNA that dictate where, when and for how long those genes are active.

MYCN and its kin are «transcription factors,» proteins that bind to DNA and influence the rate at which genetic information is used by the cell — essentially serving as brightener / dimmer switches for gene activity.

One study, to be published online September 11 in Nature Communications, found that a much smaller number of genes than previously believed serve as the ignition switch for human embryo development.

«Gene circuit switches on inside cancer cells, triggers immune attack: Advance may open new pathways for cancer immunotherapy.»

Originally, however, they were not examining brown fat thermogenesis, but instead were looking for clues to the function of ERRβ, a protein about which little was known at the time, except that it was closely related to ERRα, appeared in brown fat cells, and also worked as a so - called nuclear receptor — a molecular switch for gene activation that can be turned on by small lipophilic molecules or a signaling protein partner.

Experiments in mice suggested an important role in long - term memory for CREB, one of many so - called transcription factors, proteins that switch genes on and off.

The two species» genes for the vasopressin receptor — which relays the hormone's message to brain cells — have slightly different «promoters,» the switches that turn genes on and off.