«Fundamentally, it provides a novel mechanism
for synapse formation,» Mei said.
Not exact matches
The vision driving the project is that valuable ideas
for the treatment of stroke patients could result from accurate predictions of
synapse formation.
Astrocytes, named
for their star - like shape, are ubiquitous brain cells known
for regulating excitatory
synapse formation through cells.
In the hippocampus, a major component responsible
for memory, neural activity,
synapse formation and expression of brain - derived neurotrophic factor (BDNF) were reduced in these mice (Image 2).
«Given that abnormal
synapse formation causes various neurodevelopmental diseases such as autism spectrum disorders and epilepsy, understanding activity - dependent mechanisms of initial
synapse formation will be important
for developing new therapeutic strategies
for these conditions,» explained Dr. Kwon.
Astrocytes are responsible,
for example,
for the energy production of the brain, ion and pH balance, and they regulate
synapse formation, the connections between neurons.
Differential roles
for Wiskott - Aldrich syndrome protein in immune
synapse formation and IL - 2 production.
For example, our discovery of HORMAD1 (Fig 2) and HORMAD2, two proteins that preferentially associate with unpaired / unsynapsed meiotic chromosome cores / axes, allowed us to address how progression in meiosis is coordinated with crossover
formation, and how meiotic checkpoints / quality control ensure that only those meiocytes progress in meiosis that correctly paired and
synapsed their homologous chromosomes.
The following position is available at the Department Experimental Immunology of the Helmholtz Centre
for Infection Research (HZI) in Braunschweig: PhD candidate: Control of immunological
synapse formation in regulatory T cells.
The processes
for early brain development — neuronal migration,
synapse formation, and pruning — are responsive to and directed by environment as well as genetics.