Sentences with phrase «for synaptic proteins»

Learning more about how synapses change their connections could help scientists better understand neurodevelopmental disorders such as autism, since many of the genetic alterations linked to autism are found in genes that code for synaptic proteins.

Not exact matches

We generated knockout mice lacking synaptobrevin / VAMP 2, the vesicular SNARE protein responsible for synaptic vesicle fusion in forebrain synapses, to make use of the exquisite temporal resolution of electrophysiology in measuring fusion.

These properties, which are believed to be important for the induction of long - term changes in synaptic strength, are imparted by asparagine residues in a putative channel - forming segment of the protein, transmembrane 2 (TM2).

For years, scientists thought that manipulating these synaptic proteins might ease some of the abnormalities caused by FMRP's absence.

In nerve cells, ribosomes are also found close to the synapses of the dendrites, thus enabling proteins that are required for synaptic function to be produced close to their sites of action.

The structure of synaptophysin suggests that the protein may function as a channel in the synaptic vesicle membrane, with the carboxyl terminus serving as a binding site for cellular factors.

Moreover, in conjunction with these results, they found decreased protein synthesis, known to be required for long - term potentiation — a form of long - lasting synaptic plasticity — and for long - term memory.

It has been known for decades that triggering new protein synthesis is vital to the formation of long - term memories as well as for long - lasting synaptic plasticity — the ability of the neurons to change the collective strength of their connections with other neurons.

Indeed, when the researchers knocked out the gene for one synaptic protein, called SAPAP3, in mice they noticed something odd: After a few months, the animals developed lesions on their heads and necks.

Beginning in 1988 Scheller, then at Stanford, succeeded in characterizing several key proteins necessary for synaptic vesicle fusion with the presynaptic membrane, the prerequisite step for neurotransmitter release.

This damages nerve cells by blocking their ability to make the proteins needed for synaptic function and leads to the death of neurons in the brain and spinal cord.

The neuronal cytoskeleton regulates the architecture and dynamics of synaptic processes by providing structural support and the tracks for motor protein - based synaptic transport.

Egr proteins play a role in the regulation of synaptic plasticity, learning and memory [76, 77] and Egr3 in particular is very important for the processing of both short term and long term hippocampal dependent memory [78].

Based upon activity in multiple CNS toxicity assays, we identified an exceptionally potent, orally active, neurotrophic molecule called J147 that facilitates memory in normal rodents, and prevents the loss of synaptic proteins and cognitive decline when administered to three - month - old APP / swePS1ΔE9 mice for seven months [7].

Although protein phosphorylation is known to be important for many synaptic processes and in disease, little is known about global phosphorylation of synaptic proteins.

It has been known for many years that long - lasting forms of synaptic plasticity and long - term memory require new protein synthesis.

University home > Centre for Synaptic Plasticity > Proteins interacting with glutamate receptors > AMPAR interactors

In contrast to these proteins, it is expressed at high levels early in development (Sans et al 2000) and appears to be the principally responsible for the synaptic targetting of AMPARs at this time (Elias 2006).