Beginning in 1988 Scheller, then at Stanford, succeeded in characterizing several key proteins necessary
for synaptic vesicle fusion with the presynaptic membrane, the prerequisite step for neurotransmitter release.
We generated knockout mice lacking synaptobrevin / VAMP 2, the vesicular SNARE protein responsible
for synaptic vesicle fusion in forebrain synapses, to make use of the exquisite temporal resolution of electrophysiology in measuring fusion.
Not exact matches
The structure of synaptophysin suggests that the protein may function as a channel in the
synaptic vesicle membrane, with the carboxyl terminus serving as a binding site
for cellular factors.
«You wouldn't have time in the speed required
for synaptic transmission to make the
vesicles, load them up, and put them in the active zone ready to release them.