Sentences with phrase «for syntaxin»
The Munc18 - 1 domain 3a loop is essential for neuroexocytosis but not for syntaxin - 1A transport to the plasma membrane.
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When elevating calcium ion concentration directly at the presynaptic terminal with the use of caged calcium, cleavage of SNAP - 25 by botulinum toxin A (BoNT / A) produced a strong reduction in the calcium sensitivity for release, whereas cleavage of syntaxin using BoNT / C1 and synaptobrevin using tetanus toxin (TeNT) produced an all - or - nothing block without changing the kinetics of remaining vesicles.
In an important experiment published one year later, Jim Rothman, a Lasker Prize winner in 2002 honored for his work on fusion in non-neuronal cells, provided the experimental support for Scheller's idea by demonstrating that Scheller's VAMP, or as Rothman called it the v - SNARE, interacted with Scheller's syntaxin or t - SNARE, together with a second t - SNARE, to initiate fusion.
Scheller found, for instance, that VAMP / synaptobrevin on vesicles clasps plasma membrane - bound syntaxin, and that SNAP - 25 helps them pair up.