Sentences with phrase «for systemic diseases»

Review: The oral microbiota — a mechanistic role for systemic diseases — G Jia — British Dental Journal

[21] In the recently presented FLAURA study, in which osimertinib was used in untreated patients with advanced EGFR - mutant NSCLC, the HR for systemic disease control and CNS control similarly favored osimertinib over erlotinib or gefitinib, supporting the preclinical data that showed osimertinib's penetration across the BBB and providing support for using this agent in first - line management of EGFR - mutant patients with brain metastases.

Vaccination for localized infections tends to require more frequent boosting, whereas there is potential for vaccination for systemic disease to last for many years.

Not exact matches

The CDC (Centers for Disease Control and Prevention) also reports this about occupations that have a higher level of exposure to hazardous chemicals, «Dermal exposure to hazardous agents can result in a variety of occupational diseases and disorders, including occupational skin diseases (OSD) and systemic toxicity.»

Excess exposure to UV rays is a common trigger for increased disease activity (flare) of both cutaneous lupus and systemic lupus.

«Our study does not answer the question on possible reasons for infertility but it shows that periodontal bacteria may have a systemic effect even in lower amounts, and even before clear clinical signs of gum disease can be seen,» says Dr. Paju.

They include treatment options for patients with and without active systemic disease, along with varying degrees of inflammation of the joint lining (synovitis), as well as recommendations for repeat TB screening for JIA patients receiving biologics.

Investigators at the Medical University of South Carolina (MUSC) report pre-clinical research showing that a genetic variant encoded in neutrophil cystolic factor 1 (NCF1) is associated with increased risk for autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis, and Sjögren's syndrome, in the January 2017 issue of Nature Genetics.

Researchers at Hospital for Special Surgery (HSS) have uncovered a potential genetic trigger of systemic autoimmune disease.

«Our results, and methods, could have implications for the analysis of endogenous and exogeneous compounds in the exhaled breath as biomarkers of systemic and lung diseases, as well as in development of new approaches to study human exposure to airborne contamination.»

The polybacterial nature of periodontal disease is a risk factor for several various systemic diseases.

«We are evaluating patient and disease factors that affect the value of FDG PET / CT for systemic staging of locally advanced breast cancer,» said study coauthor Molly Parsons.

Systemic toxicity for the solenopsin derivatives has not been tested, but Arbiser says systemic toxicity would not necessarily preclude use in skin diseases, citing the example of external application of botulinuSystemic toxicity for the solenopsin derivatives has not been tested, but Arbiser says systemic toxicity would not necessarily preclude use in skin diseases, citing the example of external application of botulinusystemic toxicity would not necessarily preclude use in skin diseases, citing the example of external application of botulinum toxin.

It's hoped this latest insight will lead to the widespread use of antigen - specific immunotherapy as a treatment for many autoimmune disorders, including multiple sclerosis (MS), type 1 diabetes, Graves» disease and systemic lupus erythematosus (SLE).

dSysMap (which stands for «Disease - mutations Systemic Mapping») is a computational tool to interpret the effect of genetic mutations on the development of complex diseases.

We suggest these observations will have therapeutic implications for skeletal myopathies and systemic diseases such as diabetes and obesity and for the aged population, in which reduced endurance impacts mortality and activities of daily living (57); as well as societal implications in terms of altering athletic performance.

Current drugs for metabolic diseases rely on hormones that are systemic throughout the entire body or drugs that target entire proteins.

Long - term goal of the project will be to visualize and manipulate tau expression also in a systemic context (organotypic slice preparations, mouse brain) by affecting the function of tau mRNA - containing neuronal granules as a potential drug target for the treatment of neurodegenerative diseases.

Validating this original concept, we previously demonstrated that PGD - derived hES cells and their derivatives, which express the causal mutation implicated in the Myotonic Dystrophy type 1 (DM1), offer pertinent disease - cell models, applicable for a wide systemic mechanistic analysis ranging from functional studies at the cellular level to a large - scale drug screening.

During its Preparatory Phase, INFRAFRONTIER aimed at resolving the major issues required for implementing a sustainable INFRAFRONTIER Research Infrastructure for systemic phenotyping, archiving and distribution of mouse models of human diseases:

INFRAFRONTIER open call for disease model development and systemic phenotyping published.

Capacity building to meet the increasing demand of the biomedical research community for systemic phenotyping, archiving and distribution of mouse models of human diseases.

Lastly, increased systemic inflammation seen during ageing is also apparent in chronic infections such HIV or cytomegalovirus, 10,15 obesity7 and individuals enduring chronic psychological stress.16 Similarly, the main features of immunosenescence are apparent in many of these conditions, including decreased antibody responses, increased infections, malignancies and also incidences of inflammatory associated disorders such as cardiovascular disease.7, 10,15,16 Inflammation and premature immunosenescence are, therefore, prevalent features of many common conditions of modern life, such as obesity and stress, and could have negative health consequences for large proportions of society well before old age is reached.

Validating this concept, we previously demonstrated that human pluripotent stem cells and derivatives which, express the causal mutation implicated in the Myotonic Dystrophy type 1 (DM1), offer pertinent disease - cell models, applicable for a wide systemic analysis ranging from mechanistic studies to therapeutic screening.

Protein nitrotyrosine is a marker for inflammatory or oxidative stress processes (characteristic of COPD) and may also indicate endothelial dysfunction (systemic malfunctioning of the inner lining of blood vessels), a common cause of cardiovascular disease.

'' Managing systemic diseases like HLB is a difficult challenge that has faced plant pathologists for many years,» said Johnson «It is a privilege to work with an excellent team of researchers from many different disciplines with the goal of developing new tools that are both effective and safe.»

For example, impaired regulatory systems leading to systemic inflammation, and excessive stress responsivity, are related to biological aging1 and may partly underlie pathogenesis of cardiovascular2, 3 and Alzheimer's 4, 5 diseases (AD).

The Tissue Platform workgroup within autoimmune inflammatory diseases at Karolinska Institutet studies the effects of probes in cell assays relevant for the diseases we study, ie systemic lupus erythematosus, idiopathic inflammatory myositis, systemic sclerosis and inflammatory bowel disease.

The ability to grow in infected tissues within phagocytes is required for S. enterica virulence in systemic disease.

Inclusion Criteria: • The participant may have no more than 2 prior lines of systemic therapies (neoadjuvant and adjuvant therapies will not be considered as a prior line of therapy) for advanced or metastatic disease and is suitable to receive gemcitabine and docetaxel therapy.

Although the specific effects or consequences of FMc remain to be demonstrated in healthy women, FMc has been implicated in «alloimmunity» in some classically autoimmune diseases, for example systemic sclerosis and thyroiditis [8], [10]--[12].

While novel treatment opportunities for heart disease, like microRNA therapeutics, are often effective, systemic delivery induces a low cardiac exposure and can lead to undesirable effects in other tissues.

It includes the Rheumatology Clinical Research Unit, which currently is conducting clinical trials of novel therapies for lupus, rheumatoid arthritis, IgG4 - related systemic disease and osteoarthritis.

But while the word «lupus» (short for systemic lupus erythematosus, or SLE) has appeared in recent headlines, there's a good chance you still don't know too much about the disease.

Short for systemic lupus erythematosus (SLE), lupus is a chronic autoimmune disease that occurs when the body's immune system attacks its own healthy organs and tissues — and it can often take years to diagnose.

Given that regular consumption of sugar is a systemic inflammatory trigger, on a whole body level, how would it not contribute to «setting the stage» for periodontal disease to flourish?

Lupus (short for systemic lupus erythematosus) is an inflammatory disease that occurs when the body's immune system attacks its own tissues and organs.

For about half of those with systemic lupus erythematosus — the most common type of lupus — a major organ like the kidneys, heart, lungs, or brain will be damaged by the disease.

Today is my second anniversary since beginning treatment for Lyme Disease and multiple other systemic infections.

Recent studies have shown that belly fat is not metabolically inert, but rather actively promotes the secretion of many powerful hormones that not only make it more difficult to lose body weight, but also promote systemic inflammation that raises the risk for heart failure, cardiovascular diseases and DNA aberrations that help cancer cells to grow and metastasize.

I will add some observations from my experience, plus the documents from Vienna hospital specialized on Systemic Mastocytosis (a disease for people with high histamine intolerance): pork and turkey are the better meat than fish / cows.

Systemic inflammation is a major risk factor for a host of lifestyle - related diseases and conditions, including cardiovascular disease and stroke.»

Dercums Disease, Agressive Osteoarthritis caused by Dercum's, Systemic Lymphedema, caused by biopsy for Dercum's.

In adults, iodine is necessary not only for the production of thyroid hormones, thus affecting systemic metabolism, but is now recognized to play a protective role against fibrocystic breast disease and breast cancer.

Uncontrolled systemic inflammation places you at risk for many degenerative diseases like heart disease and stroke.

Summarized by Suzuki (2013), «Disruption of the intestinal tight junction barrier, followed by permeation of luminal noxious molecules, induces a perturbation of the mucosal immune system and inflammation, and can act as a trigger for the development of intestinal and systemic diseases» (p. 631).

Lydia, Hi I to have suffered from Diverticulitis, but for the last 18 years i have been free from that disease, for me the answer was live enzyme, s mainly from raw juice, and kefir, and enzyme supplements, like systemic enzymes have been a blessing for me, it may take up to 90 days but you will feel like a new person, full of energy, and life.

SIBO also causes systemic inflammation, which, as we know, is a major risk factor for cardiovascular disease.

Alfalfa is safe for ingestion, but it should not be taken for a long terms in supplement form, since it has been shown to cause similar reactions to those experienced with the autoimmune disease systemic lupus erythematosus (SLE).

Getting more of these supplements into your diet will greatly lower systemic inflammation and make it easier for your body to fight age related disease and illness.