Sentences with phrase «for systemic use»

In contrast to Ciclopirox, approved for topical use, Deferiprone is FDA - and EMA - approved for systemic use (in certain thalassemia patients with iron overload).

«Because of BX795's low toxicity, it has a great potential for systemic use as well as topical application.»

Not exact matches

Those systemic problems have dramatically worsened since the presidential election, with Facebook coming under intense fire on multiple fronts: Russian operatives using Facebook to manipulate voter sentiment during the presidential election, Facebook accounts spreading «fake» news, the potential for its advertising system to be used for racist targeting and its slow response to violent or harmful content on the platform.

I calculated the level of democracy using the Polity dataset from the Center for Systemic Peace, which is the only data series on democracy that goes back to the mid-19th century.

Using systemic risk scores that evaluated size, interconnectedness, substitutability, complexity, and cross-jurisdictional activities, JPMorgan came in with the most dangerous score of 5.05 for U.S. mega banks.

As the three athletes prepared for the medal ceremony, Smith and Carlos wanted to use this opportunity to protest issues of systemic injustice in the United States in three distinct ways.

After Iron Fist was rightly criticized for racial insensitivities, using the character's well - established comic book friendship with one of Marvel's most prominent black superheroes to directly confront systemic racism is a bold, smart move.

In the absence of a systemic analysis persons of goodwill can be (unwittingly) used by the powers that be for their benefit:

B Lab drives systemic change through three interrelated initiatives: 1) building a community of Certified B Corporations to make it easier for all of us to tell the difference between «good companies» and just good marketing; 2) accelerating the growth of the impact investing asset class through use of B Lab's GIIRS impact rating system by institutional investors; and 3) promoting supportive public policies, including creation of a new corporate form and tax, procurement, and investment incentives for sustainable business.

Today's sweeping indictments by federal and state prosecutors resoundingly confirm that the state's use of non-profits and SUNY to award billions in state economic development contracts has created huge and systemic opportunities for corruption.

Close to $ 2 Billion in public funds in play Today's sweeping indictments by federal and state prosecutors resoundingly confirm that the state's use of non-profits and SUNY to award billions in state economic development contracts has created huge and systemic opportunities for corruption.

The new recommendations for systemic JIA are based upon more than 1,200 clinical scenarios and include recommendations for use of the following medications:

Venkatasubramanian, who is the Samuel Ruben - Peter G. Viele Professor of Engineering, Department of Chemical Engineering, and co-director of the Center for the Management of Systemic Risk, has long been interested in fairness and inequality and points out that the same concepts and mathematics used to solve problems in statistical thermodynamics and information theory can also be applied to economic issues.

«For our new systemic viral vectors — AAV PHP.S and AAV PHP.eB — there are many potential uses, from mapping circuits in the periphery and fast screening of gene regulatory elements to genome editing with powerful tools such as CRISPR - Cas9,» says Gradinaru.

Because it has no effect on systemic fungal infections, oral amphotericin B is not FDA - approved for human use.

Systemic toxicity for the solenopsin derivatives has not been tested, but Arbiser says systemic toxicity would not necessarily preclude use in skin diseases, citing the example of external application of botulinuSystemic toxicity for the solenopsin derivatives has not been tested, but Arbiser says systemic toxicity would not necessarily preclude use in skin diseases, citing the example of external application of botulinusystemic toxicity would not necessarily preclude use in skin diseases, citing the example of external application of botulinum toxin.

The risk seemed to be higher among women who used systemic therapy and those who had used HRT for more than 10 years.

It's hoped this latest insight will lead to the widespread use of antigen - specific immunotherapy as a treatment for many autoimmune disorders, including multiple sclerosis (MS), type 1 diabetes, Graves» disease and systemic lupus erythematosus (SLE).

Development of a vaccination protocol for mucosal use (HZI): Parenteral administration induces systemic protective immunity but is inefficient in inducing mucosal immunity, whereas mucosal administration can improve both systemic and local vaccine efficacy on mucosal tissues.

The HZI will develop a vaccination protocol for mucosal administration based on three novel strategies: (i) development and optimization of a vaccination protocol in which parenterally - primed T and B cells are subsequently pulled into the mucosa by the local delivery of the cognate antigen to the requested effector site, (ii) testing the co-administration of antigens with novel mucosal adjuvants using different mucosal immunisation routes and schedules, and (iii) testing various nanoparticles co-administered with different immunomodulators for their ability to generate both systemic and mucosal immune responses following transcutaneous / trans - follicular vaccination.

However, currently available probes that use this technology fail to maximize their specificity for tumours because of strong off - target signals, and thus, have limited ability to detect small tumours in a short timespan after systemic injection.

[21] In the recently presented FLAURA study, in which osimertinib was used in untreated patients with advanced EGFR - mutant NSCLC, the HR for systemic disease control and CNS control similarly favored osimertinib over erlotinib or gefitinib, supporting the preclinical data that showed osimertinib's penetration across the BBB and providing support for using this agent in first - line management of EGFR - mutant patients with brain metastases.

These leaders in disability funding will share how they are using their financial and intellectual capital for systemic change in transition services to create a more contemporary workforce development strategy for unemployed and underemployed youth with disabilities.

In a study involving 12 patients with bladder cancer, who also underwent prostate surgery as part of their treatment, she identified the ICOS molecule as the first immunologic marker identified in both tumor tissues and the systemic circulation that can be used as a biomarker for monitoring of anti-CTLA-4 treated patients as a possible marker of therapeutic activity.

FDA Approved Ibrutinib for Relapsed, Refractory Marginal Zone Lymphoma: Approval for the use of ibrutinib in patients with relapsed or refractory marginal zone lymphoma was granted by the US Food and Drug Administration for those patients who require systemic therapy who were treated with at least one anti-CD20 therapy.

«Conceptually, in vivo mRNA delivery has been around for a long time, but its therapeutic use has been limited by poor stability, immune - reactivity and problems with reproducible systemic delivery,» says Pad Chivukula, CSO at Arcturus Therapeutics.

They have also pulled some patients away from older systemic (as opposed to topical) drugs often used for moderate - to - severe cases, such as methotrexate and cyclosporine, which patients sometimes need to take in rotation to minimize the risk of cumulative damage to their organs.

Thiamethoxam is perhaps the most versatile of the systemic types of pesticides, having been approved for use on nearly all types of fruit and vegetable crops.

I was having this issue and found relief using systemic enzyme therapy, our bodies use enzymes for everything including breaking down the uterine lining, and bonus they're good for fertility too if you're trying to conceive

Genetics, age, estrogen use and bone density are all important systemic risk factors for OA.

Steroids are used as the main treatment for certain inflammatory conditions, such as systemic vasculitis (inflammation of blood vessels) and myositis (inflammation of muscle).

In specific examples, the method 100 can be used for characterization of and / or therapeutic intervention for one or more of: acquired immune deficiency syndrome (AIDS), asthma, rheumatoid arthritis, Sprue, Sjogren's syndrome, multiple sclerosis, Type I diabetes, and systemic Lupus erythmatosus.

I am happy to report that: [stextbox id =» info»] For the last 4 months I have not been using over-the-counter medications to treat my systemic inflammation.

Further research suggests advanced systemic methylation (discussed earlier) resulting from creatine use might predispose the cell for greater IGF - 1 production.

When a remedy is needed for more systemic use but oral administration is not an option, a wet remedy or pre-prepared cream can be applied to pulse points of the body, such as behind the knee or the inside of the wrist.

Though of course as a systemic medication, the Diflucan has much greater potential for side effects, including liver toxicity when used longer term.

One of the best things that happened for women, in my opinion, in 2010, the American College of Oncologists, the cancer doctors, issued a position statement reassuring women that use of an estrogen cream on your pelvic floor, on your vaginal walls is not putting you at risk of systemic cancers and long - term risk of heart disease and stroke and things that we know that come from taking systemic hormones over the long term.

Many of the benefits of turmeric have been contributed to curcumin in isolated form, so if you're looking for something that will act as a systemic anti-inflammatory, best use a product such as [18].

It used as a safe systemic anti-inflammatory for most inflammation based diseases [8].

The botanical extractives in this formula have been used by doctors nationwide to offer additional support to individuals being treated for systemic infections and intestinal parasites.

Hi Tom Dr Will from Australia inflamation and excessive fibrin and scar tissue as well as trigliceride build up is the main reason for blockages that why I use Hydrogen 7.2 recovery 9elemental magnesium magnesium carbonate and calcium 46 mg) to seperate the red blood cells systemic enzymes in conjuction with good fats to eat away the fibrin and stop inflammation as well as grape fruit pectin to remove the hard LDLs rom the artery walls in cases that require urgency

When these same anti androgens have been used topically (put directly on the scalp) they do not cause the negative systemic side effects, but they did not seem to do much of anything for hair loss or growth either.

I never recall being tested for systemic inflammation or even counseled on risk factors other than being constantly reminded to cover up and use sunscreen.

Impairment of the highly specific nutrient uptake processes, or compromised GI barrier function, as in «leaky gut syndrome,» can result from a number of causes including: • Low gastric acid production • Chronic maldigestion • Food allergen impact on bowel absorptive surfaces • Bacterial overgrowth or imbalances (dysbiosis) • Pathogenic bacteria, yeast or parasites and related toxic irritants • The use of NSAIDs and antibiotics Impairment of intestinal functions can contribute to the development of food allergies, systemic illnesses, autoimmune disease, and toxic overload from substances that are usually kept in the confines of the bowel for elimination.

For larger or more systemic applications, it can be used as massage oil, which is reported especially effective when applied along your spinal column, massaged along your lymphatic drainage pathways.

That causes some real problems for school reform, since advocacy, research, and policy are the tools that reformers use to try to drive systemic change.

That feature is what lost the support of longtime social - justice warrior (and founder of the pro school choice Black Alliance for Educational Options) Howard Fuller, who in July shocked many allies by stating his opposition to the Nevada plan: «Parental choice should be used principally as a tool to empower communities that face systemic barriers to greater educational and economic opportunities... I could never approve of a plan that would give those with existing advantages even greater means to leverage the limited number of private school options, to the detriment of low - income families.»

I don't think that the existence of cheating «gives tacit support to arguments that standardized testing should not be used in evaluating teachers or for systemic reform,» it seems to demonstrate the problems that occur when reformers use low quality, and poorly administered, standardized tests as the primary measure of teacher quality.

At the same time, their silence gives tacit support to arguments by traditionalists that standardized testing should not be used in evaluating teachers or for systemic reform (even when, as seen this week from American Federation of Teachers President Randi Weingarten and others critical of the state education policy report card issued by Rhee's StudentsFirst, find it convenient to use test score data for their own purposes).

The AVID College Readiness System (ACRS) accelerates scholar learning, uses research - based methods of effective instruction, provides meaningful and motivational professional learning, and acts as a catalyst for systemic reform and change.