Sentences with phrase «for telomerase»

In recent years, a number of factors essential for telomerase regulation and telomere maintenance have been identified.

Researchers at the Spanish National Cancer Research Centre (CNIO) published proof - of - principle results showing a role for telomerase reverse transcriptase (TERT)...

Blasco PM, María A. Telomeric and extra-telomeric roles for telomerase and the telomere - binding proteins.

Her lab also discovered a hidden regulatory landscape on the surfaces of cellular proteins, which act as traffic cops for telomerase.

Methods: Human corneas with attached scleral rims were obtained from eye banks and were assayed for telomerase activity and BrdU (bromodeoxyridine) incorporation to determine, respectively, the presence of a stem - like cell marker and replicative activity.

Donor tissue alone (lane 1) is negative for telomerase.

Those assays were negative for telomerase activity (data not shown).

In this study, the reaction for telomerase in the peripheral corneal endothelium was manifest (Figure 2).

Within this portion they identified the TFLY, a conserved element that they showed is involved in binding the RNA component of telomerase and this interaction is important for telomerase protein - RNA assembly and activity.

This widespread lack of the need for telomerase is used by evolution as a key component of our defense against cancer, because having a limit to the size and renewal of telomeres prevents our cells from replicating themselves indefinitely — the crucial hallmark of cancer.

If it weren't for telomerase, this gradual shortening would eventually lead to the complete loss of the telomeres in cells that replicate frequently during a life span, and thus the gradual erosion of the genes themselves.

In August, 1997, Nobelist Thomas Cech of the University of Colorado at Boulder and colleagues at Geron isolated the human gene for telomerase reverse transcriptase (hTRT)-- an enzyme that reknits loosening telomeres and extends a cell's life.

The grueling 18 months unearthed a gold mine: Lundblad's team found three genes that are crucial for telomerase function, results that generated a flurry of groundbreaking papers from the members of her group in 1996 and 1997.

Not exact matches

The underlying reason is that Geron and partner Johnson & Johnson (NYSE: JNJ) are developing a first - in - class telomerase inhibitor called imetelstat for the rare blood disorders myelodysplastic syndromes (MDS) and myelofibrosis (MF).

Variants in the gene called Telomerase Reverse Transcriptase (TERT) on chromosome 5 that were associated with older IEAA were also associated with longer telomeres indicating a critical role for TERT in regulating the epigenetic clock, in addition to its established role of compensating for cell replication - dependent telomere shortening.

Voice: The 2009 Nobel Prize in Physiology or Medicine goes to Harvard's Jack Szostak, Johns Hopkins's Carol Greider and Elizabeth Blackburn at U.C. San Francisco for their work on how chromosomes are protected by telomeres and the enzyme telomerase.

For instance, one small study found that people who ate healthier diets, did yoga or meditation, and exercised daily increased the activity of telomerase, which could lead to longer telomeres.

For now, the only diseases clearly caused by shortened telomeres or dysfunctional telomerase are rare premature aging disorders like dyskeratosis congenita.

Telomerase adds back the lost DNA and keeps cancer cells, for example, forever young.

Several biotech companies — most prominently Geron, which first made a name for itself in telomere research — are working to develop anticancer drugs that would work by deactivating telomerase.

New experiments by UC Berkeley and UCSF researchers suggest that immortalization of skin cells, which is essential to turning them cancerous, is a two - step process: a mutation in nevus cells slightly raises levels of telomerase, which keep the cells alive long enough for a second change, still unknown, that up - regulates telomerase to make the cells immortal and malignant.

«Our findings have implications for how to think about the earliest processes that drive cancer and telomerase as a therapeutic target.

Some would simply crank their telomerase activity up even further; some would enhance the activity of drug - metabolizing enzymes that degrade the inhibitor; still others would change their cell surface proteins in ways that would make it harder for the drug to penetrate into the cell.

The TERT promoter mutation does not generate enough telomerase to immortalize the pre-cancerous cells, but does delay normal cellular aging, Hockemeyer said, allowing more time for additional changes that turns telomerase up.

As with all of our other genes, the DNA that encodes the telomerase enzyme is present in all of our cells — but because it's needed only after quite a few cell divisions have occurred, it's not needed in most cells for most or all of the time, so it's turned off.

To insiders, telomerase was a much better prospect for drug development than the Werner protein.

However, the researchers believe that these results are proof of concept that gene therapy is a valid strategy against aplastic anemia; this therapy could also be applied to other genes — besides from telomerase — if a causal role for those other forms of the disease was discovered.

«This TFLY motif comprises a significant part of the binding pocket that enables the enzyme to grapple the RNA template and guide it to the active site of the enzyme for catalysis,» Skordalakes said, «but it also facilitates the stable association of the protein with its RNA component thus forming a fully functional telomerase enzyme.»

In their research project in 2012, the researchers substantially delayed the aging of mice by enabling their cells to produce telomerase once again for a period of time.

This model structure of the catalytic portion of telomerase shows how the TFLY motif (green) is positioned at the entry of the pocket that guides the RNA template in the interior cavity of the telomerase ring and were the active site of the enzyme if located for catalysis.

The treatment is based on making bone marrow cells express the telomerase enzyme, which is responsible for repairing telomeres.

While increased telomerase activity could bring youth to aging cells and cure premature aging - like diseases, too much of a good thing can be damaging for the individual.

When telomerase restarts DNA synthesis for the next DNA repeat, this pause signal is still active and limits DNA synthesis.

Small molecule drugs can be screened or designed to increase telomerase activity exclusively within stem cells for disease treatment as well as anti-aging therapies without increasing the risk of cancer.

«People have been targeting telomerase as a potential cancer therapy for a long time,» he says, noting that anti-telomerase drugs are in phase II clinical trials against several cancers.

Augmenting and regulating telomerase function will have to be performed with precision, walking a narrow line between cell rejuvenation and a heightened risk for cancer development.

In this webinar, our experts will describe the advances in telomere research as it applies to human health and how deeper characterization of the telomerase maintenance process can uncover targets for therapies.

When it filed for a patent on the gene, it didn't list the academic collaborators as co-inventors, although Greider maintains that her lab contributed biochemical protocols for purifying telomerase that were crucial to Geron's discovery.

Greider and Ariel Avilion, a grad student working in her lab toward a Ph.D. from the State University of New York, Stony Brook, were attempting to find and isolate the gene for the RNA portion — dubbed hTR — of human telomerase.

The studies on autophagy by Yoshinori Ohsumi, which earned him the Nobel Prize in Medicine in 2016, and the discovery of cell cycle regulatory genes for which Leland Hartwell, Timothy Hunt and Paul Nurse received the same award in 2001, including the research of Elizabeth Blackburn, Carol Greider and Jack Szostak on telomeres, telomerase and its protective effect on the chromosomes, were all made possible thanks to yeast.

Telomerase is an enzyme responsible for the production of telomeres, which play an important role in the regulation of normal cell division.

They have become a valuable resource for biologists, enabling momentous scientific breakthroughs including the development of the polio vaccine the Nobel Prize winning studies defining the role of telomerase in aging, and research on the causative role of human papillomavirus (HPV) in some types of cervical cancer.

Arsenic, the researchers found, stops a gene for an important part of the telomerase enzyme, known as the reverse transcriptase subunit, from being translated.

Scientists say that the findings are exciting because, though disrupting telomerase has looked like a good strategy for treating cancer, it's been difficult to pinpoint compounds that do so.

As a safeguard, in cells such as egg, sperm, and stem cells, an enzyme called telomerase is responsible for preventing this wear and tear by maintaining telomere length.

The 2009 Nobel Prize in physiology or medicine goes to Harvard's Jack Szostak, Johns Hopkins's Carol Greider and Elizabeth Blackburn at U.C. San Francisco, for their work on telomeres and telomerase.

An inherently high stalling frequency of the S. cerevisiae telomerase may account for its in vitro properties and for the irregular telomeric sequences of this yeast.

Related sites Richard Cawthon's Web site Basic introduction to telomeres and telomerase American Federation for Aging Research

Telomerase has been hailed as a potential elixir for eternal youth.

The telomerase ribonucleoprotein has a phylogenetically divergent RNA subunit, which contains a short template for telomeric DNA synthesis.