Sentences with phrase «for telomere»

Conclusion «The data suggest that increases in perceived control and decreases in negative affectivity contributed to an increase in telomerase activity, with implications for telomere length and immune cell longevity», the researchers conclude cautiously.

But he ended up winning the Prize for the telomere work that he had done earlier.

«Our findings reveal a critical role for telomere length in a mouse model of age - dependent human disease,» said first author Christina Theodoris, an MD / PhD student in the laboratory of Deepak Srivastava, MD. «This model provides a unique opportunity to dissect the mechanisms by which telomeres affect age - dependent disease and also a system to test novel therapeutics for aortic valve disease.»

Of all the cancers, pancreatic had the largest increase in incidence related to longer telomeres, with participants in the highest one - fifth for telomere length at nearly 2.6 times the odds of developing pancreatic cancer, compared to those in the lowest one - fifth for telomere length.

«We think that this protruding loop provides the entering site for the telomere overhangs to tuck in to form the T - loop structure.

The study, led by scientists from the University of Chicago, uses a novel method to measure genetic predisposition for telomere length, rather than physiological measures which are confounded by factors such as age and lifestyle.

Now, in a move that brings these questions into sharper focus for the general public, Telome Health, founded by Elizabeth Blackburn, who won the Nobel for Medicine for her work in this area, has announced that it will bring to market a test for telomere length.

Because of a quirk in the way the DNA is replicated, the ends are not completely copied, and that information would gradually be lost if not for the telomeres.

Every time linear chromosomes are replicated during late S phase, the DNA polymerase complex is incapable of replicating all the way to the end of the chromosome; if it were not for telomeres, this would quickly result in the loss of vital genetic information, which is needed to sustain a cell's activities.

But we were all trying different ways, and the ones I learned turned out to be totally appropriate for telomeres.

People carrying the variant might further accelerate the biological aging process if they smoke, are obese or don't exercise — all of which are bad news for telomeres.

Not exact matches

Blackburn conducted research focused on mothers caring for children with autism and other chronic conditions, and found that moms who were more resilient to stress — perceiving their situation as a challenge, rather than something hopeless or overwhelming — kept their telomeres longer.

In case you haven't heard enough about how beneficial meditation can be, here's another way researchers have found that it helps: Family members who meditated for as little as 12 minutes a day for two months while caring for a relative with dementia improved their telomere maintenance.

Chromosome 2 and its extra centromere and telomere regions argues against special creation for the same reason male nip - ples and our defunct egg yolk protein gene argues against special creation.

Variants in the gene called Telomerase Reverse Transcriptase (TERT) on chromosome 5 that were associated with older IEAA were also associated with longer telomeres indicating a critical role for TERT in regulating the epigenetic clock, in addition to its established role of compensating for cell replication - dependent telomere shortening.

Researchers from several institutions, including, UCLA, Boston University, Stanford University and the Institute for Aging Research at Hebrew SeniorLife, analyzed blood samples from nearly 10,000 people to find that genetic markers in the gene responsible for keeping telomeres (tips of chromosomes) youthfully longer, did not translate into a younger biologic age as measured by changes in proteins coating the DNA.

Although enthusiasm for the research services runs high, some telomere experts question the tests» current value for individuals.

Whenever chromosomes — the storehouses of our genes — are replicated in preparation for cell division, their telomeres shorten.

In this study, the proportion of women in the longest telomere tertile was higher for women in the fourth quartile of maternal age at the birth of their last child than in the first quartile (35.7 % vs 20.2 %).

Voice: The 2009 Nobel Prize in Physiology or Medicine goes to Harvard's Jack Szostak, Johns Hopkins's Carol Greider and Elizabeth Blackburn at U.C. San Francisco for their work on how chromosomes are protected by telomeres and the enzyme telomerase.

Over a year and a half, this small but dedicated group grew 350,000 yeast colonies, picked out and cultured 35,000 promising mutants, and, for a selected subset of those, analyzed their telomere lengths.

Lundblad, a tall woman whose wavy brown hair is touched with gray, has been studying telomeres for almost 20 years.

Lundblad's success contributes to telomere biology's reputation for claiming a large number of women investigators.

With a grant from the National Institute on Aging, she launched another search for yeast strains with defective telomere maintenance, but on a far larger scale than in her postdoctoral work.

And there's enough evidence of a connection to disease, causal or not, for folks to start wondering what their telomere length means for the future.

The most important question for people taking the telomere test, though — whether you can do anything about your shrinking telomeres, if indeed they cause disease — is the one that still needs the most research.

For instance, one small study found that people who ate healthier diets, did yoga or meditation, and exercised daily increased the activity of telomerase, which could lead to longer telomeres.

«Such a relationship between leukocyte telomere length and physical activity level remained significant after adjustment for body mass index, smoking, socioeconomic status and physical activity at work,» the authors report.

For now, the only diseases clearly caused by shortened telomeres or dysfunctional telomerase are rare premature aging disorders like dyskeratosis congenita.

In August, 1997, Nobelist Thomas Cech of the University of Colorado at Boulder and colleagues at Geron isolated the human gene for telomerase reverse transcriptase (hTRT)-- an enzyme that reknits loosening telomeres and extends a cell's life.

The clarification of the mystery of whether Shugoshin controls the subtelomeres or similar control systems work in humans as well may lead to the elucidation of a mechanism for developing abnormal telomere structure such as multiple malformation and mental retardation.

A large - scale genetic study of the links between telomere length and risk for five common cancers finds that long telomeres are associated with an increased risk of lung adenocarcinoma.

A research group discovered a new function of the chromosomal terminus, which may lead to the clarification of the mechanism for developing abnormal telomere structure such as multiple malformation and mental retardation.

The team suggests a potential explanation for this observation is that long telomeres enable more rounds of cell division than short telomeres, which could allow cells to live longer and have more opportunities to accumulate carcinogenic mutations.

Work on Telomeres Wins Nobel Prize in Physiology or Medicine for 3 U.S. Genetic Researchers [Update]

It is unclear whether shrinking telomeres will be problematic in culturing human tissue transplants, but if it turns out they are, Geron has an answer for that too.

They found that longer telomeres were significantly associated with increased risk for lung cancer — specifically lung adenocarcinoma, which more than doubled in risk for every 1000 base pair increase in telomere length.

Since genetics remain unchanged even as telomeres physically shorten, this measurement allowed for unbiased comparisons to cancer risk.

To search for new enzymes that could repair telomeres, the researchers — Susan Smith, Titia de Lange, and their colleagues at Rockefeller University in New York City — used a biochemical screen to find substances that interact with TRF1, a human protein known to bind to telomeres.

The telomere G - tail length is essential for the biological effects of telomere dysfunction in vitro.

Nevertheless, it provides initial evidence for the association of telomere G - tail length with aging, endothelial function, and ARWMCs in patients with vascular risk factors.

And without knowing tankyrase's exact function, it's «too early to tell whether [the enzyme] is a good target for drug discovery,» cautions telomere expert Calvin Harley of Geron Corp. in Menlo Park, California.

He worked there for 3 years, continuing his research on telomeres and pioneering the microarray techniques that form the basis of his international reputation.

Several biotech companies — most prominently Geron, which first made a name for itself in telomere research — are working to develop anticancer drugs that would work by deactivating telomerase.

It potentially also suggests applications for the human ageing process even at old age when telomere length has already decreased,» said Dr Grishma Rane, Research Fellow at CSI Singapore and co-first author of the study.

So we might just be able to deal with cell loss if we had a sufficiently sophisticated program of stem cell replenishment — using cells engineered to lack the one linchpin function for cancer, namely telomere elongation.

If it weren't for telomerase, this gradual shortening would eventually lead to the complete loss of the telomeres in cells that replicate frequently during a life span, and thus the gradual erosion of the genes themselves.

This widespread lack of the need for telomerase is used by evolution as a key component of our defense against cancer, because having a limit to the size and renewal of telomeres prevents our cells from replicating themselves indefinitely — the crucial hallmark of cancer.

Even chronic stress can wear away our telomeres, according to research done in the early 2000s that looked at mothers caring for children with chronic diseases.

Yamaki added that it's important for the public to understand that heavy drinking causes telomere shortening because «awareness of this fact provides important information necessary for people to live healthier.»