Sentences with phrase «for thalidomide»

A safe substitute for thalidomide would be well received.

Ito and colleagues hope the identification of cereblon as a target for thalidomide teratogenicity will lead to rapid screening for similar, safer alternatives.

Not exact matches

That thalidomide was not approved for sale in the United States was more of a bureaucratic fluke than anything else.

For some time, no one suspected that thalidomide was the cause of the significant increase in the incidence of phocomelia.

Don't wait for the too little too late DES and thalidomide style recalls, decades after the fact.

When asked by Nature for relevant studies, the plaintiffs» lawyers at Hagens Berman Sobol Shapiro in Seattle, Washington, pointed to work showing one - sided limb defects in chick embryos exposed to thalidomide and thalidomide analogues (C. Therapontos et al..

In a new twist of a historic tragedy, 13 Americans who say they are survivors of thalidomide are suing four companies for producing and distributing the notorious drug.

President John F. Kennedy honors FDA medical officer Frances Kelsey in 1962 for her work blocking U.S. approval of thalidomide.

For example, in its current work, the team showed that the micro-hearts didn't develop properly if exposed to thalidomide, a drug that infamously resulted in birth defects when pregnant women took it to treat morning sickness.

Scathing of drugs companies and the way they often put profits before human life, he had earlier fought for the rights of victims of the drug thalidomide.

The company in - licensed thalidomide in 1992 and received FDA approval to market the drug (as Thalomid) for treating severe cutaneous manifestations of leprosy in 1998 and for treating multiple myeloma in combination with dexamethasone in 2006.

Starting in 2008, Marzia Lazzerini of the Institute for Maternal and Child Health in Trieste, Italy, and her colleagues randomly assigned 54 children with Crohn's to get daily thalidomide or a placebo.

Worldwide, roughly 10,000 affected children nicknamed «thalidomide babies» were born with multiple defects, including the characteristic shortened upper limbs (a condition known as phocomelia, Greek for «seal limbs»), before the drug was discontinued in 1961 after four years on the market.

Now, for the first time, researchers have found a specific protein that binds to thalidomide and may help explain its devastating effects on fetal development.

In the late 1950s and early 1960s, doctors prescribed thalidomide as an antinausea drug for pregnant women with a regularity that proved tragic.

We also have tested several promising treatments, including a monoclonal antibody and thalidomide for Crohn's disease.

Dr. Kelsey, 69, was honored for her successful crusade to prevent the marketing of the sleeping pill thalidomide in the United States.

He was well known for playing a crucial role, as an expert witness, in winning compensation for the victims of thalidomide.

In other work, Henning Moelle has been acting as international lead counsel for the pharmaceutical company Grünenthal in product liability claims for alleged birth defects caused by thalidomide.

Meyer had said among other things that for 30 years the Contergan (thalidomide) manufacturer Grunenthal GmbH had had access to the medical files of the Contergan victims in the Contergan Foundation.

Representing Grünenthal on the major product liability case involving a claim for damages in over $ 204m filed by the Spanish Association AVITE (Asociación de Víctimas de la Talidomida en España) representing 184 victims of thalidomide, for alleged damages caused in the 1960's for the administration of thalidomide.