Sentences with phrase «for therapeutic intervention in»
«Our research on the role of blood proteins in brain functions has identified new targets for therapeutic intervention in multiple sclerosis and other neurological diseases,» said Dr. Akassoglou.
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Through these studies he has identified a new transcription factor and associated pathway that could yield new avenues for therapeutic intervention in SMA.
Newer CXCR4 antagonists are under clinical evaluation for therapeutic intervention in various cancers, hematologic and vascular disorders, HIV infection, and other immune system disorders involving the modulation of the SDF - 1 / CXCR4 axis, such as rheumatoid arthritis and lupus [54 - 56].
The phosphatases are also promising targets for therapeutic intervention in the treatment of various cancers,» Dr. Varjosalo states.
NMNATs are potential drug targets for therapeutic interventions in neurodegeneration.
Not exact matches
SSP is a great way to help children and adults move through major transitions (such as starting school, starting a new job, going on vacation) and prepare for participation in other therapeutic interventions.
Athletic Trainers work closely with physicians and other health professionals and are responsible for being current in several areas, including: an evidence based practice (EBP), prevention and health promotion (PHP), clinical examination and diagnosis (CE), acute care of injuries and illnesses (AC), therapeutic interventions (TI), psychosocial strategies and referral (PS), healthcare administration (HA), and professional development and responsibility (PD).
We offer a number of therapeutic services for children from one year of age through adolescence that include individualized speech and language therapy, parent training to facilitate language development in children who are late talkers or stuttering, and interventions to facilitate social communication and pragmatics.
«Our study highlights the multifaceted pathophysiology of Dravet Syndrome that includes brain, heart, and autonomic disturbances, and suggests novel therapeutic strategies for interventions to reduce SUDEP in this and perhaps other severe epilepsies,» says David S. Auerbach, Ph.D., of the University of Michigan.
«We hope that our work will provide the basis for a larger study of patient samples that may ultimately identify biomarkers that can be used as surrogate markers to determine the benefit of therapeutic interventions in diagnosed but asymptomatic HD patients to prevent or delay disease onset.»
If, however, you are more interested in research you could become a health outcomes researcher, collecting data on therapeutic interventions for drug companies, or there is the Scientists Training Programme offered by the NHS.
This highlights a temporal window for potential therapeutic intervention, in order to preserve the beneficial effects of enhanced neurogenesis.
Therapeutic hypothermia (targeted temperature management) is an established intervention for certain types of cardiac arrest, stroke and asphyxia patients and is used to protect neurological function, but its impact on renal protection in the transplantation setting has been unknown, according to the researchers.
The authors conclude that this newly discovered allosteric mechanism «suggests that allosteric modulation in nucleosomes may have biological relevance and potential for therapeutic interventions.»
«Our tests indicate we can operate on tiny structures such as blood vessels without damaging them,» said Thomas Looi, the project director for one of the partners that developed KidsArm at the Hospital for Sick Children (SickKids) Centre for Image - Guided Innovation & Therapeutic Intervention (CIGITI) in Toronto, Canada.
Since small, early - stage cancers are the most responsive to drug treatments, screening is an important aspect of follow - up care for breast cancer patients, and early detection is critical in tailoring appropriate and effective therapeutic interventions.
They surmise that methods to measure clot contraction could be used for diagnosis of its effects on bleeding or thrombosis, and perhaps in the future these effects might even be modulated with therapeutic interventions.
Whether stimulating beta cells to grow will result in therapeutic interventions for diabetes is still to be seen, but this new information opens the door to find out, said Sander.
We hope that knowledge derived from this new taxonomy will comprise an important first step in facilitating international cooperation of research, ultimately leading to new avenues for diagnosis and therapeutic intervention.»
Of late there has been a surge of interest in investigating the relatively underexplored innate immune system as a possible tool for therapeutic intervention.
Further exploration of the TCA cycle, using metabolomics, may identify novel therapeutic targets for CKD and in turn may help us evaluate the effects of promising interventions.»
Their findings, which appear in the journal Nature Neuroscience, also point to a potential therapeutic intervention for alleviating memory - related disorders.
This novel and informative work may provide an immunologic explanation for the observed therapeutic efficacy of autologous HSPC transplantation in T1D and pave the way for new therapeutic interventions in the future.
Importantly, these studies provide the foundation for the in vivo characterization of the mechanisms that contribute to drug - induced cognitive impairments that will greatly facilitate the design and testing of therapeutic interventions to ameliorate excessive impulsivity that sabotages attempts at prolonged drug abstinence.
We hope that our work will provide new insight into the signaling mechanisms responsible for establishing brain circuitry, and ultimately suggest therapeutic interventions for disorders in which these signaling mechanisms are perturbed.
Facilities for PET - CT, in situ data - logger expertise and equipment for non-invasive quantification of disease progression and therapeutic intervention is available.
The Benefits of Biomarkers in the Search for a Cure When a patient undergoes a therapeutic intervention, physicians currently have no way of knowing whether the treatment worked.
The call seeks to address the need for innovative research to underpin new approaches to therapeutic intervention, connect centres with a critical mass of resources and expertise to drive a step change in neurodegeneration research.
The resulting data are being combined in a systems biology approach with high - resolution clinical phenotyping and findings obtained with a large array of established and novel in vitro, ex vivo and in vivo disease models to identify disease - associated genetic variants, disease - defining molecular signatures, and potential targets for therapeutic intervention.
Ultimately, a better molecular - level understanding of the regulatory mechanisms that control ALC1 activity may in the long term open up new horizons for therapeutic intervention strategies», Deindl says.
The findings suggest that therapeutic interventions aimed at restoring TRN activity might make up for related deficits in patients.
Targeting MYC as a Therapeutic Intervention for Anaplastic Thyroid Cancer JCEM March 28, 2017 Keisuke Enomoto, Xuguang Zhu, Sunmi Park, Li Zhao, Yuelin J. Zhu, Mark C. Willingham, Jun Qi, John A. Copland, Paul Meltzer, and Sheue - yann Cheng Anaplastic thyroid cancer (ATC) is one of the most aggressive cancers in humans.
The laboratory has investigated the roles of these molecules in inflammatory and autoimmune diseases to determine if modulating their activity alters the immune response and may be useful for therapeutic intervention.
«This research improves our understanding of the biological processes that underlie cognitive dysfunction in this disease and could open the door for new therapeutic interventions.»
The lab recently developed novel LumiFluor ® optical reporters and are now implementing these reporters for the non-invasive, high resolution in vivo optical imaging of tumor development, progression, and response to therapeutic intervention in genetically engineered mouse models (GEMM) of cancer.
«In the future,» said Dr. Akassoglou, «this thrombin - specific probe could be developed to one day allow for early patient diagnosis and therapeutic intervention — including a way to effectively monitor how patients are responding to the latest treatments.»
Establishing the role of cigarette smoke in progression of cancer will not only produce the necessary evidence for implementing smoking cessation interventions but may also help to identify cellular mechanisms for therapeutic targeting.
Simply put, both disorders prevent normal development of the central nervous system, resulting in premature death in children, presenting an urgent need for effective therapeutic intervention.
Although finding the gene (s) responsible and the regulatory regions that are relevant for such conditions does not automatically lead to a cure, such findings can give important clues about what is malfunctioning at the cellular level, a required step in designing therapeutic interventions.
Results from these studies will provide direct evidence for the importance of these nutritional factors in maintaining retinal health and preventing advanced retinal disease, and may reveal new options for therapeutic intervention.
This in turn can provide insight into the key cellular pathways that are potentially amenable for therapeutic intervention.
For example, the counterintuitive management strategy in such an encephalitis case would be to suppress the immune system — not a therapeutic intervention one would necessarily consider in the case of a pathogen caused disease.
Their work points to opportunities for therapeutic interventions — even in the first few weeks of life — that might improve long - term outcomes for the preemies.
Current clinical measures are limited by floor and ceiling effects and lack sensitivity to change with time, especially in premanifest subjects who are likely to be the optimal candidates for therapeutic intervention.
These studies have opened up new avenues for therapeutic intervention throughout the different stages, and have also aided in the identification of biomarkers that can help in determining disease diagnosis and prognosis.
Together with the region - specific progression of plaque densities, these models present a valuable tool for early intervention and improved assessment of potential therapeutic approaches for AD and in particular AD - induced aggression.
In specific examples, the method 100 can be used for characterization of and / or therapeutic intervention for one or more of: acquired immune deficiency syndrome (AIDS), asthma, rheumatoid arthritis, Sprue, Sjogren's syndrome, multiple sclerosis, Type I diabetes, and systemic Lupus erythmatosus.
One particular case study in the form of an intervention trial noted the therapeutic effect of creatine for treating PTSD.
Dr. Minich will be presenting two talks at the Nutritional Therapists of Ireland (NTOI) Conference in Dublin on June 23, 2018: «Clinical Understanding and Assessment of Toxic Exposures» and «Therapeutic Interventions for Holistic Detoxification».
1935 Effects of the high carbohydrate - low calorie diet upon carbohydrate tolerance in diabetes mellitus 1955 Low - fat diet and therapeutic doses of insulin in diabetes mellitus 1958 Effect of rice diet on diabetes mellitus associated with vascular disease 1976 Beneficial effects of a high carbohydrate, high fiber diet on hyperglycemic diabetic men 1977 Effect of carbohydrate restriction and high carbohydrates diets on men with chemical diabetes 1979 High - carbohydrate, high - fiber diets for insulin - treated men with diabetes mellitus 1981 High carbohydrate high in fibre diet in diabetes 1982 Response of non-insulin-dependent diabetic patients to an intensive program of diet and exercise 1983 Long - term use of a high - complex - carbohydrate, high - fiber, low - fat diet and exercise in the treatment of NIDDM patients 1994 Diet and exercise in the treatment of NIDDM: the need for early emphasis 1999 Toward improved management of NIDDM: A randomized, controlled, pilot intervention using a lowfat, vegetarian diet 2005 The effects of a low - fat, plant - based dietary intervention on body weight, metabolism, and insulin sensitivity 2006 A low - fat vegan diet improves glycemic control and cardiovascular risk factors in a randomized clinical trial in individuals with type 2 diabetes 2006 Effect of short ‐ term Pritikin diet therapy on the metabolic syndrome 2009 A low - fat vegan diet and a conventional diabetes diet in the treatment of type 2 diabetes: a randomized, controlled, 74 - wk clinical trial