Sentences with phrase «for transplant therapy»

One of the compounds retested, amiodarone HCL, was further tested for possible effects on postmitotic neurons, a likely target for transplant therapy.

The finding, published in the current issue of Genes and Development1 represents a different approach to cultivating specialized cells for transplant therapy than that being pursued in other labs.

Not exact matches

K, next time you need major surgery, or chemo therapy for cancer, or a lung transplant, just PRAY for it.

The findings, published online Nov. 13 in Science Translational Medicine, could pave the way for improvements in preventing GVHD and rejection of transplanted bone marrow and new therapies to prevent or treat a relapse of the underlying cancer after a transplant.

Researchers are developing molecular switches that can inactivate transplanted genes, paving the way for safer gene therapies.

In April of this year, the team reported that patients responded well, with no serious complications, suggesting the therapy might also work for face transplants.

And early stage startup Neochromosome, which includes Boeke, intends to raise money to design synthetic chromosomes for medicine that could be used in an off - the - shelf universal cell line in cell therapies and transplants with minimal risk of rejection from the immune system.

Eye diseases — such as age - related macular degeneration, as well as a genetic condition called Stargardt's macular dystrophy that afflicts young people — are considered excellent candidates for stem cell therapy because the eye is an immune - privileged site, meaning transplanted cells are not as likely to be rejected as foreign compared with transplants elsewhere.

Diabetes researchers are considering various replacements for insulin injections: Transplanting new pancreatic islet cells that make insulin, coaxing the patient's own islets to regenerate, or treating diabetics early in the disease with immune - suppressing therapies to prevent their body from destroying the rest of their pancreatic islets.

An extended transplant window could make time for drug or stem - cell based treatments — even gene therapy.

However, in the wake of fatalities from gene therapy and other technologies, as well as the potential for cancers associated with stem cell transplants, governments are understandably nervous about safety issues — not to mention the ethical maze of tinkering with fledgling life.

In a related editorial, Michael G. Ison, MD, MS, Medical Director of the Transplant & Immunocompromised Host Infectious Diseases Service for Northwestern Medicine and associate professor of Infectious Diseases and Organ Transplantation at the Northwestern University Feinberg School of Medicine, noted additional benefits associated with antiviral therapy for influenza, including reductions in lower respiratory infections, hospitalizations, antibiotic use, and stroke risk.

He is a proponent of fecal transplant therapy as a primary treatment for C. difficile, rather than as a last resort.

If researchers can unlock the secrets of this cellular process, therapies that replace diseased cells with healthy ones may one day be possible — brain - cell transplants to combat Alzheimer's, for instance, or even the creation of whole organs from scratch.

Just what triggers the cells surrounding a zebra fish's injury to start dedifferentiating is unknown, but Keating says regenerative therapy for human beings will in some circumstances involve transplanting stem cells to the injured area.

On the flipside, targeting this growth factor or BCL - 2 could reduce NK cell numbers and offer potential therapies for immune disorders such as some types of autoimmune diseases, sepsis or graft versus host disease, a side effect of bone marrow transplants.

But he also believes that medical researchers will overcome some of the thorny obstacles to safe and effective therapies — just as once seemingly insurmountable obstacles to kidney transplants were overcome — clearing the way for treatment of diseases such as Parkinson's, blindness, and immune disorders.

Hematopoietic stem cell transplantation (HSCT), once considered an effective yet risky alternative to drug therapy for blood cancer, has become more accessible and successful in a wide range of patients as a result of major advances in transplant strategies and technologies.

Such research promises to give scientists a better understanding of how transplanted tissue connects to the nervous system, paving the way for improved regenerative therapies in humans.

«Stem cell therapy may help recondition lungs previously rejected for transplant.»

«Because of relatively low survival rates and their advancing age, these patients tend to be poor candidates for aggressive therapies, like a bone marrow transplant,» said senior author Catriona Jamieson, MD, PhD, professor of medicine, chief of the Division of Regenerative Medicine at UC San Diego School of Medicine and director of the Stem Cell Research Program at Moores Cancer Center.

One of the biggest challenges for medical researchers studying the effectiveness of stem cell therapies is that transplants or grafts of cells are often rejected by the hosts.

A bone marrow transplant is the only standard treatment, but the gene therapy approach, developed by researchers at the San Raffaele Telethon Institute for Gene Therapy in Milan, Italy, offers a new line of therapy approach, developed by researchers at the San Raffaele Telethon Institute for Gene Therapy in Milan, Italy, offers a new line of Therapy in Milan, Italy, offers a new line of attack.

The agency has also been promised an extra $ 101 million to help improve the safety of drugs, devices, blood, and medical therapies, including efforts to bolster safety of cord blood and human tissue for transplant.

Today, at 56, Atala oversees 300 researchers and support personnel, including chemists, biologists and engineers divided into different teams working on cell therapy, a technology for what he calls partial transplants and the creation of new organs.

Findings of a three - year clinical trial led by University of Cincinnati (UC) transplant researchers suggest that a novel pre-operative drug therapy reduces antibodies in kidney patients with greater success than with traditional methods, with the potential to increase the patients» candidacy for kidney transplantation and decrease the likelihood of organ rejection.

A new perspective paper written by researchers at the Perelman School of Medicine at the University of Pennsylvania and published in The New England Journal of Medicine suggests that «new antiviral therapies with cure rates exceeding 95 percent should prompt transplant - community leaders to view HCV (hepatitis C virus)- positive organs as a valuable opportunity for transplant candidates with or without pre-existing HCV infection.»

«Antibodies in the blood provide clues to transplant recipients» likelihood of rejection: Presence of certain antibody types may indicate the need for aggressive anti-rejection therapy.»

«Stem cell transplants may advance ALS treatment by repair of blood - spinal cord barrier: ALS mice improved with stem cell therapy; first step for science in finding better treatment.»

Using this system upon request from a patient, it has become possible to treat the patient ineligible for a heart transplant or destination therapy and use this technique for tunneling the internal power cable through the neck to the head, which is approved overseas, but not in Japan.

This observation shows promise for people undergoing cancer therapy who have also had a kidney transplant.

Thus far, patients with previous diseases such as irreversible kidney disorder were ineligible for a heart transplant or destination therapy.

Many researchers blamed the therapy for disrupting the patients» DNA, but a new study suggests that the transplanted gene itself may have triggered the cancer.

The therapy is approved by the U.S. Food and Drug Administration for relapsed or treatment - resistant Hodgkin lymphoma, and it is commonly prescribed to patients whose disease has progressed after autologous stem cell transplant, a procedure that replenishes the bone marrow with the patient's own healthy stem cells after therapy.

But new research with kidney transplant patients provides a proof of principle for a cellular therapy that may eliminate the need for antirejection drugs.

Tandon uses electrical signals and environmental manipulations to grow artificial tissues for transplants and other therapies.

«The loss of insulin - producing beta cells leads to type 1 diabetes, making it an ideal target for cell replacement therapy,» said James Shapiro, MD, PhD, FRCSC, Director of the Clinical Islet Transplant Program, University of Alberta.

Research Interests: Immunologic memory; memory T - cells; allograft rejection; transplantation; therapies for transplant recipients

Regardless of the targeted organ for cell replacement or regeneration, the shared challenges in cell therapies for diabetes such as transplant procedure and immune rejection will be well - served by the collective expertise within CCTD.

Through the UCSD Clinical Cardiovascular Cell Therapy program, Dib and collaborating cardiology faculty plan to conduct clinical studies in a number of areas, including the effectiveness of adult stem cell transplant as a treatment for congestive heart failure; as a way to minimize heart damage after a heart attack; and in the formation of new blood vessels (angiogenesis) to increase blood flow to the heart for patients experiencing chest pain.

For example, the biology of dendritic cells is now being used to explore vaccines and therapies to prevent infectious diseases, autoimmune disorders, allergy, cancer, and rejection of organ transplants.

Most of the diseases treated by stem cell transplant are rare among children; however recent trials with cord blood have shown promise for stem cell therapy treating more common childhood conditions such as cerebral palsy, autism and others.

The potential for cell therapy to play a role in the therapy of myelin disorders is under serious consideration, based on years of experimentation of glial cell transplants in experimental models.

But what's more, the transplanted cells keep producing a foreign protein slipped inside with the help of a lentiviral vector, the kind usually used for gene therapy.

The South Florida Bone Marrow / Stem Cell Transplant Institute is now running a new clinical trial protocol (08001 - BMSCTI) for investigating a novel cancer therapy using transfusions of white blood cells from healthy donors.

These adult stem cells can be safely and easily collected and can even be stored for possible future use should the individual require stem cell therapy (transplant) later in life.

So far, for all the enthusiasm over stem cell therapies, there are only a few that have been validated — including bone marrow transplants to treat certain blood cancers — and those that have been around for years.

We offer a full spectrum of treatment services on site, including chemotherapy and radiation therapy, pre - and post transplant care for blood and bone marrow stem cell transplantation, as well as cancer screenings and supportive care services such as patient support groups and a cancer resource center.

Wake Forest Baptist's cardiothoracic team and surgeons deliver exceptional results for all types of heart conditions through procedures such as aortic valve replacements, heart bypass surgery, heart transplants and surgeries and therapies for thoracic aneurysms.

Researchers at Harvard - affiliated McLean Hospital have found that fetal dopamine cells transplanted into the brains of patients with Parkinson's disease were able to remain healthy and functional for up to 14 years, a finding that could lead to new and better therapies for the illness.