Not exact matches
Once activated, T cells can home in on a
tumor and target it
for destruction.
At the same time, other switches get flipped throughout the body, modifying everything from metabolism to cell growth, via other cytokines, such as IL - 6 and
tumor necrosis factor — a, and things like CRP, which mark bacteria
for destruction.
The selective pressure of the competent immune system «edits» the
tumor by selecting
for cells that can avoid immune
destruction.
In effect, Affigen uses cancer's «Achille's Heel»: the proteins which distinguish
tumor cells from normal cells, that can target
tumor cells
for destruction with extreme sensitivity and precision.
They are important especially
for the
destruction of cells infected by a virus or of
tumor cells.
Through its various targets, MMP1 promotes not only
tumor invasion but also breast cancer colonization to bone by mechanisms that include the release of membrane - bound EGF - like growth factors from
tumor cells, leading to activation of EGF receptor signaling and suppression of OPG expression in osteoblasts, which in turn promotes the differentiation and activation of osteoclasts required
for bone
destruction and enhanced
tumor growth in the bone microenvironment (32).