Sentences with phrase «for tumor formation»

ln hOSA, the Hedgehog (HH) developmental and cellular signaling pathway has been documented to contribute to the pathogenesis of the disease, impacting genes responsible for tumor formation and metastasis.

It is thought that compounds added to killed - virus vaccines called adjuvants may be responsible for the tumor formation.

Inhibition of ROS induced by reflux may be a useful strategy for preventing DNA damage and decreasing the risk for tumor formation caused by GERD, they concluded.

Transplanting non-cardiac stem cells also increases the risk for tumor formation, as many of the cells turn into other cell types besides the target heart cells.

We are also investigating targeting the normal source of HB - EGF, inflammatory cells, to determine whether HB - EGF alone or in concert with other cytokines produced by inflammatory cells is necessary for tumor formation.

Not exact matches

The discovery of a treatment capable of blocking the mechanism responsible for the formation of metastasis and the existence of a family of promising compounds, is encouragement for their future assessment in a clinical study that aims to validate a preventive treatment against tumor metastasis.

Many more microchimeric cells are found in the blood of healthy women compared to those with breast cancer, for example, suggesting that microchimeric cells can somehow prevent tumor formation.

And that also means there might be a magic bullet (to stop tumor formation) for all cancers.»

This treatment prevented the formation of polyps, showing that bacteria are essential for early tumor development in this model.

If the silencing occurred in a gene responsible for suppressing tumor formation, the result would appear the same as genetic mutations that predispose people to cancer.

For example, genes involved in suppressing tumor formation are turned off via epigenetic mechanisms, and genes involved in rapid growth and replication are turned on too high.

When the scientists inserted human colorectal cancer cells into zebrafish embryos and allowed them to grow for 4 days, the resulting tumors showed three hallmarks of human solid tumors: rapid cell division, formation of blood vessels to supply nutrients, and the ability to spread to other locations in the body.

This group's achievement shows the possibility to clarify the mechanism of human tumor formation, especially the molecular mechanism responsible for in the initial stage of cell cancerization due to DNA damaged by radiation in the initial stage, by using the model of budding yeast, a primitive eukaryote.

Joining forces with dermatologists and oncologists from the University Hospital in Zurich and backed by the University Research Priority Program «Translational Cancer Research,» Sommer's team was able to demonstrate that, in melanoma cells, the epigenetic factor EZH2 controls genes that govern tumor growth as well as genes that are important for the formation of metastases.

Petris says that understanding the roles of copper in biology may have far - reaching health implications for the general population because copper underpins many facets of biology, including the growth of cancer tumors and the formation of toxic proteins in Alzheimer's disease.

Under the microscope, it is possible to identify invasion of the tumor into the lymph and blood vessels, this being the tumor behaviour responsible for the formation of metastases, so that it can be used as a prognostic factor.

«These strategies would focus on promoting myelination in the peripheral nervous system for neuropathic disease or inhibiting Schwann cell over-proliferation that occurs during formation of peripheral nerve sheath tumors like neurofibromas.»

Because tumor growth is a concern when cells are reprogrammed to an earlier stage of development, the researchers followed the mice in the Nature Cell Biology study for nearly a year to look for signs of tumor formation and reported finding none.

The key experiments included for replication were selected because they examine the induction of POSTN expression in the pulmonary stromal fibroblasts and test the role of POSTN in primary tumor formation and metastatic efficiency, which are relevant as the role of POSTN as a possible prognostic marker and target for anticancer therapies is explored (Xu et al., 2012; Nuzzo et al., 2014).

«Why premature cell division promotes cancers: Researchers have discovered how genes responsible for cell division, when mutated, disrupt the replication process of the genome and promote tumor formation.»

MMTV - PyMT + / tg; Postn − / − mice and their Postn + / + counterparts were analyzed for primary tumor formation and metastasis.

«The CDK4 and 6 proteins are critical drivers of the cell - division cycle and are required for the formation and growth of various types of solid tumors,» says Dana - Farber's Shom Goel, MD, PhD, co-first author of the study with Molly DeCristo of the Hematology Division at BWH.

Judah Folkman demonstrates that tumors express factors that encourage new blood vessel formation, or angiogenesis, suggesting that targeting these factors to slow or halt angiogenesis could be a viable strategy for cancer treatment.

In a study, published in Science, they investigated a gene region that contains a particular single nucleotide variant associated with increased risk for developing colorectal and prostate cancers — and found that removing this region caused dramatic resistance to tumor formation.

Having a pure population of cardiac muscle cells is essential for avoiding tumor formation after transplantation, but has been technically challenging.

«For example, in certain cancers, genes may be switched on at the wrong times, eventually leading to the formation of tumors,» said Brandon Razooky, a Gladstone and UCSF graduate student and the paper's other lead author.

MACC1 is also responsible for the formation of secondary tumors (distant metastases).

Secondly, before considering the use of iPSC - derived organoids for transplantation / regenerative medicine in human patients, the current protocols for expansion, reprogramming and differentiation of iPSCs in long - term cultures need further improvement to minimize the risk of oncogenic cellular mutations and teratoma, or tumor formation, in the patient.

Miller said that other proteins anchored to the cell surface in a similar fashion are known to play roles in cell proliferation, suggesting a possible mechanism for how HYAL2 might be involved in tumor formation.

He and the Vereide Group grow precursors of human arterial cells, build colonies of dendritic cells (cells which can alert the rest of the immune system to the presence of a tumor), and use chick embryos to study the formation of early tissue layers for a possible future in which complex tissues, or even organs, can be grown to replace diseased, wounded, or malfunctioning ones.

However, when these mice were tested for the ability to form tumours after activation of an oncogenic signal that causes colorectal cancer in humans, they showed dramatic resistance to tumor formation.

Fifty percent tumor formation required 3.1 × 105 hypoxia pretreated MCF7 cells, whereas 6.5 × 105 control MCF7 cells were required for the same level of tumor formation suggesting a 2-fold increase in tumor - initiating cells (Fig. 1E).

E, in vivo tumor formation for ER - positive (MCF7) and negative (468) cells following 21 % or 1 % pretreatment (numbers represent mice in group).

Using a model where K - ras acts as an oncogene and initiates tumor formation, mice that were bred to not have Notch1 function showed an almost uniform distribution of about two cancerous lesions per mouse after 6 weeks, compared with approximately 14 tumors / mouse for those with Notch1 function still remaining.

Likewise, wild - type MELK cooperates with a second oncogene, for example NeuT, to induce tumor formation in vivo.

Therefore, the use of C188 - 9 provides an independent confirmation of the necessity for STAT5 activation to mediate pregnancy's promotion of tumor formation, alongside the experiments using STAT5a - / - mice (Figure 5) and those using two independent Jak inhibitors (AG490 and ruxolitinib; Figure 6A - F).

«Estrogen is preventative of tumor formation for colon cancer, we believe,» says Allred.

Meds are more targeted Avastin, for instance, is a so - called angiogenesis inhibitor, which blocks the formation of blood vessels that feed tumors.

Polyunsaturated fats such as corn oil and soybean oil are highly unstable and vulnerable to oxidation — and oxidation, in turn, is linked to cancer — while the omega - 6 fatty acids that predominate in vegetable oils have been shown to accelerate the growth of tumor cells.6 As Fallon and Enig explain, 4 excessive consumption of toxic polyunsaturated oils — not red meat — represents a known mechanism for colon cancer: «Colon cancer occurs when high levels of dietary vegetable oils and hydrogenated fats, along with certain carcinogens, are acted on by certain enzymes in the cells lining the colon, leading to tumor formation» [Emphasis added].

; The Anti-Wrinkle Diet; Increasing Muscle Strength with Fenugreek; How Tumors Use Meat to Grow; Mushrooms for Breast Cancer Prevention; Prevent Breast Cancer by Any Greens Necessary; Foods That May Block Cancer Formation; and Breast Cancer & Alcohol: How Much Is Safe?.

; How Tumors Use Meat to Grow; Mushrooms for Breast Cancer Prevention; Foods That May Block Cancer Formation; Flax Seeds for Prostate Cancer; Flax and Breast Cancer Survival; and Treating Breast Pain with Flax Seeds.

They inhibit tumor blood vessel formation (angiogenesis) and tumor cell migration (needed for metastasis).

Despite the extremely low incidence of this problem, the problem is still very serious and the veterinary profession has responded with numerous studies on how vaccines might be related to tumor formation, why is the incidence so low given how many vaccines are given to cats annually, what can be done for prevention.

We then ultrasonically scale away plaque and tartar, x-ray your pet's teeth and jaw to identify deeper concerns, perform oral surgery to extract teeth or remove oral tumors, thoroughly polish the tooth surfaces, apply dental sealants to reduce further plaque and tartar formation, and create an oral health plan for your pet.

They are associated with tumor formation and are not being used in animals or humans for therapy.

For my patients, dietary supplementation of digestive enzymes, especially those that contain the fat digesting enzyme Lipase - are key in preventing and resolving fatty tumor formation.

Despite the extremely low incidence of this problem, the problem is still serious and the veterinary profession has responded with numerous studies on how vaccines might be related to tumor formation, why the incidence is so low given how many vaccines are given to cats annually, and what can be done for prevention.