Sentences with phrase «for tumor profiling»

Most cancer patients would opt for tumor profiling even if the test revealed that they or their families were at risk for other genetic diseases, according to a Yale Cancer Center study.

Not exact matches

«Next generation sequencing tools were used to profile patients» tumors,» said Razelle Kurzrock, MD, director of the Center for Personalized Cancer Therapy at UC San Diego Moores Cancer Center.

Traditional genetic approaches together with the new wealth of genomic information for both human and model organisms open up strategies by which drugs can be profiled for their ability to selectively kill cells in a molecular context that matches those found in tumors.

«For example, it is conceivable to deep - freeze a human tumor immediately after surgical removal and to precisely determine its biological and pathophysiological profile with the new method,» explains Pichler.

The 15 AACR scientists, who were already in Washington, D.C., to meet with the U.S. Food and Drug Administration on genetic testing for cancer patients, tossed around ideas including expanding NCI's tumor genome - sequencing efforts and getting the government to cover the costs of genomic tumor profiling.

The study showed that despite the risk for receiving information about other potentially serious health problems, 59 % of the cancer patients would agree to tumor profiling if offered by their physician.

«While tumor profiling holds the promise of improved therapeutics through personalized medicine, it is important that both clinicians and patients discuss the possibilities of incidental findings prior to ordering the testing, as the findings can have serious implications for both the patient and their family members,» said Melinda Yushak, M.D., M.P.H., first author on the study and a medical oncology fellow in Yale School of Medicine.

Nagrath, director of Rice's Laboratory for Systems Biology of Human Diseases, said the new metabolic analysis indicates that ovarian cancer may be susceptible to multidrug cocktails, particularly if the amounts of the drugs can be tailored to match the metabolic profile of a patient's tumor.

Researchers at Rice University's Laboratory for Systems Biology of Human Diseases analyzed the metabolic profiles of hundreds of ovarian tumors and discovered a new test to determine whether ovarian cancer cells have the potential to metastasize.

In 2011, she joined the institution's molecular diagnostics laboratory where she has been developing translational next generation sequencing assays and bioinformatics workflows for the Molecular Tumor Profiling Lab of the Yale Cancer Center.

One project involves probing Foundation Medicine's growing database of tumor profiles for specific mutations and using that information to either design drugs or to parse patients into clinical trials of the company's drugs, says Pao.

Analyzing the poly - G profiles of primary and metastatic colon cancer samples from 22 patients revealed that how the primary and metastatic tumors related to each other was different for each patient.

Research from Rutgers Cancer Institute of New Jersey examining difficult to treat cancer tumors through genomic profiling shows that tumors with alterations in a signaling pathway responsible for cell regulation may respond to targeted therapy regardless of where the tumor originated in the body.

The study wasn't designed to measure whether tumor profiling made a difference in how patients fared, but «it nonetheless lays the groundwork for more systematic study of the impact of genomics on clinical practice and patient outcomes,» the report said.

Collaborations to access and profile immune cells in patient tumors are also underway to provide the relevant disease context for our current and future targets.

Using an array of techniques, including RNA sequencing and targeted gene expression profiling, the researchers searched for links between gene activity and protein production in these tumors and the clinical outcomes of patients.

Zebrafish larva implanted with cancer patient's tumor (red) RITA FIOR / CHAMPALIMAUD CENTRE FOR THE UNKNOWNSee R. Fior et al., «Single - cell functional and chemosensitive profiling of combinatorial colorectal therapy in zebrafish xenografts,» PNAS, doi: 10.1073 / pnas.1618389114, 2017

For some types of cancer, the existence of certain subtypes had not been known until researchers began to profile the genomes of tumor cells.

It has specialized workflows for both rare inherited disorders as well as somatic tumor profiling tests.

To develop the methodology, the group analyzed the molecular profiles of human embryonic stem cells and compared them with data for 12,000 samples of 33 different tumor types held by The Cancer Genome Atlas (TCGA), a U.S. public database.

Examples include the study of allelic variation in the human genome and the development of computational methods for the discovery of cancer - associated genes and diagnostic cancer markers using genomic profiles derived from different tumor types.

He also observed that dietary protein stimulated tumor growth, but that when restricted for a short period (6 - 12 weeks), the immune profile changed and the white T - cell count improved.

While not diagnostic for SCC, the diagnostic work - up includes complete blood count and serum chemistry profile, lymph node assessment via cytology, and chest x-rays in order to confirm that the tumor SCC is confined to the mouth.

Because of the nature of this tumor, laboratory testing (complete blood count, biochemistry profile, and urinalysis) and diagnostic imaging (radiographs and ultrasound) are important tests to screen the body for tumor involvement.

Changes in serum biochemistry profile for dogs with hepatic tumors may also indicate hypoglycemia, hypoalbuminemia (levels of albumin in blood serum are abnormally low), hyperglobulinemia (condition characterized by large amounts of globulins [any class of proteins not soluble in water but soluble in saline solution] in blood) and increased pre and post prandial bile acids (before and after eating a meal).

If you are searching for a proven Clinical Trials Doctor with more than 20 years» experience, who will generate innovation and provide compelling and innovative molecular profiling of patients» tumors and possible treatments for refractory cancers, please contact me to arrange an interview.

Co-author of the Bisgrove Phase I clinical trial published in fall 2009: A Pilot Study Using Molecular Profiling of Patients» Tumors to Find Potential Targets and Select Treatments for their Refractory Cancers.