Not exact matches
Chitayat wonders whether
proliferation could proceed in unexpected ways,
for example leading to
tumors — a worry that cuts across many stem cell therapies.
The resulting endothelial cell lines described in this study retain their phenotype after repeated passage, require minimal nutritional support and, importantly, may be useful
for identifying factors that regulate endothelial cell
proliferation and
tumor cell adhesion in different anatomical regions.
Researchers at the University of Chicago noted that in recent years, genetically engineered herpes simplex virus studied
for its efficacy against malignant
tumors of the central nervous system and the liver was blocking certain types of cell death and
proliferation of surviving cells.
Miller said that other proteins anchored to the cell surface in a similar fashion are known to play roles in cell
proliferation, suggesting a possible mechanism
for how HYAL2 might be involved in
tumor formation.
We have appreciated
for some time the causes of this uncontrolled
proliferation, in particular the roles of proto - oncogenes,
tumor suppressors, and their protein products.
(2016) ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important
for Cellular
Proliferation and
Tumor Growth.
A great deal of evidence has now been amassed that stromal cell senescence plays an important role in laying the groundwork
for tumor metastasis, promoting cell
proliferation with inflammatory cytokines, encouraging angiogenesis, and degrading the
tumor - suppressive action of an intact extracellular matrix.
The lab is delineating
tumor dormancy in melanoma and characterizing subpopulations of cells with a major focus on slow - proliferating cells that have high
proliferation potential hypothesizing that these cells are critical
for dormancy and therapy resistance.
Culture media
for tumor cells were supplemented with 10 % FBS, whereas culture medium
for HUVEC was supplemented with 20 % FBS, with the exception of the experiment under low
proliferation rate conditions (2 % FBS).
New data and research approaches have created opportunities
for researchers to study in detail many aspects of cancer biology, including how the normal biological programs of cell
proliferation and death are altered during cancer and how the immune system responds to
tumors.
In these cases, UroSEEK could be detecting clonal
proliferations in the bladder epithelium that did not progress to cancer, and such
proliferations may be more common in patients with BC than in the general population Risques and Kennedy, 2018Because only one biopsy from the primary
tumor was available
for comparison, it is also possible that intratumoral heterogeneity explains some of the discrepancies.
Clonal
proliferations may also be the basis
for any discordance between mutations in urinary cells and in the primary
tumors of the same patients.