The ability for cancer cells to develop resistance to chemotherapy drugs - known as multi-drug resistance - remains a leading cause
for tumor recurrence and cancer metastasis, but recent findings offer hope that oncologists...
The ability for cancer cells to develop resistance to chemotherapy drugs — known as multi-drug resistance — remains a leading cause
for tumor recurrence and cancer metastasis, but recent findings offer hope that oncologists could one day direct cancer cells to «turn off» their resistance capabilities.
Not exact matches
After adjusting
for age,
tumor location, and stage, researchers from Cleveland Clinic's Dermatology & Plastic Surgery Institute discovered that women diagnosed with malignant melanoma during their pregnancy or within one year of giving birth were 5.1 - times as likely to die, 6.9 - times as likely to experience metastasis, and 9.2 - times more likely to have a
recurrence.
In melanoma, they can be used to determine
tumor stage, diagnosis, therapy selection and when to monitor
for disease
recurrence.
«Surgery is the main treatment option
for patients with most solid
tumors, but
recurrence and metastasis remain significant problems,» says study senior author Michael Goldberg, PhD, assistant professor at Dana - Farber and Harvard Medical School.
According to follow - up reports, Zola remained well
for eight more years before dying from a
recurrence of the
tumor in his native Italy.
The study, which will not be completed
for at least five years, will evaluate whether the vaccine prevents
tumor recurrence rather than causing shrinkage.
This analysis suggests that a rare subset of
tumor cells harbor different genetic alterations and that those cells serve as the seeds
for the
recurrence of rhabdomyosarcoma.»
Cancer stem cells, a type of self - renewing cell found in
tumors, are of particular interest because they are the main cell type responsible
for tumor progression and
for resistance to chemotherapy and radiotherapy, and therefore a major cause of
tumor recurrence after treatment.
And although a
recurrence of the cancer — this time in his brain — would eventually claim his life on November 8, 1991, the fact that his lung
tumor disappeared completely begs
for an explanation.
A new study by UCLA scientists has found that women diagnosed with breast cancer and treated with a one - week regimen of partial breast radiation after the surgical removal of the
tumor, or lumpectomy, saw no increase in cancer
recurrence or difference in cosmetic outcomes compared to women who received radiation of the entire breast
for a period of up to six weeks after surgery.
«We found an association between increased breast cancer
recurrence in women with a primary breast cancer
tumor that was positive
for the IGF1 receptor, which is consistent with other studies,» said Emond.
Dartmouth researchers have found that reducing carbohydrate intake could reduce the risk of breast cancer
recurrence among women whose
tumor tissue is positive
for the IGF - 1 receptor.
Tumor recurrence was faster and more likely among African American patients, particularly
for basal subtype
tumors or those driven by the TP53 mutation.
«The higher risk of
tumor recurrence that we observed among African American women was reduced when controlling
for those factors, suggesting that these genomic differences contribute, at least partly, to the known racial disparity in the survival of African American and Caucasian breast cancer patients.»
A study from investigators at the Massachusetts General Hospital (MGH) Cancer Center has,
for the first time, identified genomic differences between the breast
tumors of African American and white women, differences that could contribute to the recognized differences in
recurrence rate and survival.
The vaccine was administered to six patients with melanoma whose
tumors had been removed by surgery and who were considered at high risk
for recurrence.
Each chart was reviewed
for patient demographics, presenting symptoms and signs,
tumor location and size, imaging findings, extent of surgical resection, histopathological findings, radiographic follow - up,
tumor recurrence, and clinical outcome.
Grade 1
tumors had the lowest post-surgery peak
for local
recurrence, while grades 2 and 3 showed similar rates.
In the new study, published online March 27, 2018, in Cell Reports, a team led by UCSF's David Raleigh, MD, PhD, found that increased activity of a gene known as FOXM1 appears to be responsible
for the aggressive growth and frequent
recurrence of these
tumors.
DENVER — Three manuscripts published in the recent issue of the Journal of Thoracic Oncology, the official journal of the International Association
for the Study of Lung Cancer (IASLC), explored the versatility of liquid biopsies by identifying EGFR mutations using circulating
tumor DNA (ctDNA) in urine and plasma and examining circulating
tumor cells (CTCs) in plasma to predict the risk of lung cancer
recurrence after surgical resection.
Almost all brain and pituitary
tumor patients undergo repeated MRI scans after treatment to observe
for the possible
recurrence of their
tumors.
Research shows that,
for people at risk of
recurrence, there is a longer period of time before the
tumor recurs.
Dormant
tumor cells in a hypoxic bone marrow niche (19) will be enriched
for CSC in ER - α — positive breast cancer but depleted in ER - α — negative cancers profoundly influencing the capacity
for late disease
recurrence.
This
tumor recurrence often shows up in different sites such bones, lung, liver, or brain and primarily responsible
for breast cancer related deaths.
The 20 - year and 40 - year
recurrence rates
for thyroid
tumors were 6 and 9 %.
If you have a pre-existing
tumor or Human Growth Hormone deficiency due to a brain lesion, you should be examined routinely
for progression or
recurrence of the underlying disease process while receiving Human Growth Hormone.
«Oral
tumors are more difficult to remove surgically and this may account
for the higher rate of
recurrence.»
Sadly, though, Harley's biopsy came back as a malignant spindle cell
tumor which means he will have to be watched
for signs of
recurrence.
Even with treatment, no therapy
for SCC is 100 percent effective and
tumor recurrence is high, with approximately one in five horses experiencing cancer relapse.
If the mammary
tumor is malignant, the surgical site and regional lymph nodes should be checked
for local
tumor recurrence and metastasis, respectively, every 3 months
for the first 12 months after surgery and then every 6 months thereafter.
For dogs with large breast
tumors (> 3.0 cm), the prognosis tends to be poor since there is an 80 % chance of
recurrence of the
tumor within 6 months after canine breast cancer treatment.
In dogs, the size of malignant mammary
tumors is an important consideration when determining prognosis, both
for local
tumor recurrence and survival time.
Lymphatic
tumors are difficult to cure surgically and multiple
recurrences are common, even
for benign
tumors.
If an owner's dog was affected by epulis, the person needs to perform routine check - ups as recommended by the vet in order to monitor the dog
for potential
recurrence of the
tumor.
Those with the greatest risk
for recurrence are those with large, high grade (II & III), or those with multiple
tumors.