«Our findings show that high - intensity circulating tumor DNA sequencing is possible and may provide invaluable information for clinical decision - making, potentially without any need
for tumor tissue samples,» said lead study author Pedram Razavi, MD, PhD, a medical oncologist and instructor in medicine at Memorial Sloan Kettering Cancer Center (MSK) in New York, NY.
Not exact matches
Plasma
samples of patients with NSCLC is a less invasive method and has been used as surrogate
tumor tissues for detecting genetic alterations.
The authors acknowledge that «
tumor tissue should be considered the preferred
sample type when available, however, our encouraging results suggest that a single plasma - derived ctDNA
sample may be considered appropriate
for assessment of EGFR mutation status when
tumor tissue is unavailable or exhausted.»
The researchers next will turn to analyzing the presence of myoferlin in
samples from numerous human
tumor types available in an Ohio State
tissue bank, which will allow them to compare protein levels in
tumors to clinical outcomes
for the patients who provided the
samples.
For the study, researchers investigated
tissue samples from 297 people with brain
tumors.
They analyzed bacterial DNA found in breast
tissue samples from 58 women who were undergoing lumpectomies or mastectomies
for either benign or cancerous
tumors, as well as from 23 healthy women who had undergone breast reductions or enhancements.
«Being able to safely take
tissue samples will also allow us to test
for specific
tumor sub-types and better decide the most appropriate treatment
for each individual patient,» added Dr Booton.
NYGC computational biologists and members of the Simon Laboratory at The Rockefeller University discussed the possibility of using a series of computer algorithms to search
for sequence differences between the
tumor samples and
samples of healthy liver
tissue.
The researchers took healthy
tissue and
tumor samples from mice, and trained the nanoparticle - GFP sensors to recognize the bad cells, and
for the GFP to fluoresce in the presence of metastatic
tissues.
To that end, Sharma gave an overview of MD Anderson's efforts to comprehensively characterize the activity of the immune cells in the patients they treat, and they've already analyzed over 42,000
tumor tissue samples, from both before and after treatment, looking
for clues regarding how treatment outcomes relate to immune cell infiltration into
tumors.
Guided by a camera and the ultrasound probe, Waxman carefully positioned the endoscope over the
tumor and passed a fine needle into the pancreatic lesion to
sample tissue cells
for biopsy.
The researchers used
tumor tissue samples from melanoma patients to search
for variations in their internal messaging.
3/24/2008 Non-Invasive Imaging Provides Window Into Genetic Properties of Brain
Tumors Doctors diagnose and prescribe treatment for brain tumors by studying, under a microscope, tumor tissue and cell samples obtained through invasive biopsy or su
Tumors Doctors diagnose and prescribe treatment
for brain
tumors by studying, under a microscope, tumor tissue and cell samples obtained through invasive biopsy or su
tumors by studying, under a microscope,
tumor tissue and cell
samples obtained through invasive biopsy or surgery.
In
tumor samples, where we frequently encounter variants with a very small allele frequency due to contamination with normal
tissue, copy number variation, and
tumor heterogeneity, high coverage is essential
for accurate detection of these variants with high power.
For example, proteins related to angiogenesis, the process through which new blood vessels form to ensure supply of oxygen and nutrients to a
tissue such as a
tumor, are found to be clearly associated to clinical outcome in HPV - positive
samples.
Also stored in those freezers are
tumor tissue samples that can be used
for research.