Sentences with phrase «for tumor types»

The role of chemotherapy in cats and dogs with malignant mammary tumors has not been clearly defined for all tumor types but oncologist consultation after surgery is often recommended.

«We also need to integrate PIK3CA mutation analysis of breast tumors into routine practice so that we can ensure women receive the most appropriate neoadjuvant therapy for their tumor type.»

It is difficult to interpret an aspiration sample for this tumor type because cell yields are low and the cells of the aspirates are identical to those of normal fat.

A biopsy may be indicated to rule out a certain kind of tumor called inflammatory mammary carcinoma, as surgery is generally not recommended for this tumor type

It is difficult to interpret for this tumor type because cell yields are low and the cells of the aspirates are identical to those of normal fat.

Not exact matches

It's wrong for this type of tumor.

While it has shown promise for some types of tumors and become standard of care for others, researchers are just beginning to explore how different immunotherapy technologies can be applied to brain cancer.

The partnership will seek approval for a version of the Illumina's test, TruSight Tumor 170, as a companion diagnostic for Loxo's larotrectinib and another one of Loxo's experimental cancer drugs, across tumor tTumor 170, as a companion diagnostic for Loxo's larotrectinib and another one of Loxo's experimental cancer drugs, across tumor ttumor types.

For example, TCGA, with genomic data on 33 tumor types taken from samples from 11,000 patients, is finishing 2018 by publishing a series of papers and holding a symposium.

Global cancer genomics research also helps us understand geographical hotspots for certain tumor types.

Types 6 and 11 account for about 90 percent of genital warts as well as non-cancerous tumor growths in the respiratory tract.

The Wnt pathway is known to be inappropriately activated in many major tumor types, including colon, breast, liver, lung and pancreatic cancers, and is critical for the function of CSCs.

OX40 functions as a throttle for T cells, another type of immune cell crucial for battling tumors, and the anti-OX40 antibodies rev up these cells.

The findings also have potential uses for most other types of solid tumors, including those affecting the lungs and ovaries, because the same protein and enzyme are involved, François said.

«Each tumor type may acquire a unique set of capabilities that may provide tumor - specific growth and survival advantages, which may need to be determined for each kind of cancer.

For each patient, the suitable combination treatment could then be designed, which, in the first step, would turn the variety of different tumor cells into a mass of cancer cells of the same type.

The study looked for two of the most common types of brain tumors — gliomas, which are often malignant, and meningiomas, which are more often benign — in people ages 20 to 79 in Denmark, Finland, Norway and Sweden between 1974 and 2003.

«If we can define which types of mutations and changes are the critical events driving tumor growth, we will be better equipped to identify the most appropriate treatments for individual cancers.»

Consequently, «metformin is being studied in various solid tumors,» Karmalis says, «and has the potential to change treatment paradigms for a number of cancer types,»

That's why we applied different cancer types — not just for solid tumors, but for cancers like leukemia,» Gu said.

Glioblastoma is the most aggressive type of tumor that originates in the brain and with no curative treatments currently available, the average survival time for patients ranges from 15 to 18 months.

Purushotham points out, «The feasibility of intraoperative CLI as shown in this study, in combination with the wide applicability of F -18-FDG across a range of solid cancers, provides a stepping stone for clinical evaluation of this technology in other solid cancer types that also experience incomplete tumor resection due to close or involved margins.»

Second, we believe the vaccine may be particularly beneficial for a group of patients with the HLA - A2 type, which suggests that as we move forward, there may be advantages in targeting this population,» said John Yu, MD, vice chair of the Department of Neurosurgery, director of surgical neuro - oncology, medical director of the Brain Tumor Center and neurosurgical director of the Gamma Knife Program at Cedars - Sinai.

The authors acknowledge that «tumor tissue should be considered the preferred sample type when available, however, our encouraging results suggest that a single plasma - derived ctDNA sample may be considered appropriate for assessment of EGFR mutation status when tumor tissue is unavailable or exhausted.»

Philip Laipis of the University of Florida, who has also observed tumors in AAV vector - treated mice, agrees, at least for studies using a similarly high dose of AAV to target liver cells, which are more likely than other cell types to take up the AAV vector.

The researchers next will turn to analyzing the presence of myoferlin in samples from numerous human tumor types available in an Ohio State tissue bank, which will allow them to compare protein levels in tumors to clinical outcomes for the patients who provided the samples.

For many years, Dr. Ohashi's team has been studying tumor - infiltrating lymphocytes (TILs), which are the cell type known to kill cancer cells.

Cancer stem cells, a type of self - renewing cell found in tumors, are of particular interest because they are the main cell type responsible for tumor progression and for resistance to chemotherapy and radiotherapy, and therefore a major cause of tumor recurrence after treatment.

However, such tumor cells display unusual antigens that are either inappropriate for the cell type or its environment, and can thus be recognized by the body's immune system.

«Not only did we find that LIGHT expression promoted tumor regression, upon further study we also identified the specific type of T - cell — CD8 — that was responsible for shrinking the tumor,» Maker said.

A relatively new biomarker called prostate - specific membrane antigen (PSMA) is the bullseye for three new magnetic resonance imaging (MRI) agents that bind to the protein in not only prostate cancer, but a range of tumor types, according to research unveiled at the 2015 annual meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI).

A nanoparticle drug - delivery system that combines two complementary types of anticancer treatment could improve outcomes for patients with pancreatic cancer and other highly treatment - resistant tumors while decreasing toxicity.

Narrowing the treatment to a particular tumor cell type makes for a more effective — and less harmful — oncolytic approach.

Unlike other solid tumors, there has been limited progress in understanding the contribution of genetic risk factors to the development of uveal melanoma, researchers say, primarily due to the absence of comprehensive genetic data from patients as the large sample cohorts for this rare cancer type have not been available for research.

Apart from the tumor type, the choice of treatment sometimes has to take into account implications for the woman's fertility.

Adds Liu: «With metastatic cancers accounting for around 90 % of deaths from solid tumors, the hope is that one day a device that can enable the analysis of single tumor cells circulating in the blood could make a big difference in early diagnosis, detection and monitoring of numerous types of cancer, without invasive biopsies.»

In the United States, the ABI is approved for use only in patients 12 years or older with neurofibromatosis type II, an inherited disease that causes a non-malignant brain tumor on the hearing nerve, but it has shown limited effectiveness in adults.

«First drug target identified for children with rare type of brain tumor.»

Tumors are home to diverse immune cell types, some of which remain much less explored than T cells and could also control cancer progression» says Mikael Pittet, PhD, director of the Cancer Immunology Program in the MGH Center for Systems Biology and senior author of the Science paper.

Dr. Le, who holds the Thomas L. Shields, M.D. Professorship in Dermatology, said he and his researchers serendipitously uncovered this explanation for balding and hair graying while studying a disorder called Neurofibromatosis Type 1, a rare genetic disease that causes tumors to grow on nerves.

«We were amazed when we found this new type of disease — tapeworms growing inside a person, essentially getting cancer, that spreads to the person, causing tumors,» said study researcher Dr. Atis Muehlenbachs, a staff pathologist at the Centers for Disease Control and Prevention's Infectious Diseases Pathology Branch (IDPB).

She estimates that about 50 percent of women with ovarian cancer have tumors with this type of tumor and would qualify for the trial, which needs about $ 2 million in philanthropic funding before it could begin.

In the Dec. 1 issue of Science, the team from the MGH Center for Systems Biology describes a «crosstalk» between lung tumors and bone marrow, which leads to the generation of a type of immune cell that travels to the tumor and promotes its progression.

Answering important clinical questions — such as whether genetic diversity is a risk factor for aggressive tumor development or how it relates to treatment resistance — requires analyzing samples from many patients with different types of cancer.

Two case studies provide an important potential new avenue for treatment of these types of tumors, which are resistant to traditional radiation therapies and difficult to manage even with surgery, the current standard of care.

Using tumor models for both astrocytoma and oligodendroglioma, which are very similar to human tumors, they could show that one and the same cell type, called oligodendrocyte precursor cells, could give rise to both tumor forms.

«A number of other types of tumors have been shown to be driven by chimeras, but this one is unique — it codes for a kinase, an enzyme that modifies other proteins, that has not been identified in cancers.»

The research, published online May 26 by Nature Immunology, shows that GATA - 3 is required for the maintenance and function of CD8 + T - cells, a T - cell type mediating the immune response to clear pathogens, eradicate tumors and promote inflammation.

A larger study to address this, as well as other fluorescent agents for other tumor types that do not express FRα, are being planned, Burggraaf added.

Another possibility that Irvine's lab is working on is developing treatments that could be used against tumors even when scientists don't know of a specific vaccine target for that type of tumor.