Sentences with phrase «for tumorigenesis»

Then, the single - cell suspension was used for tumorigenesis or serial transplantation experiments.

As reported this month in Nature, the in vivo screen focused on 133 metabolic genes that the researchers predicted to be necessary for tumorigenesis.

Not exact matches

«As bioengineers, we can now design 3D culture systems where environmental parameters such as composition, porosity, and stiffness can be precisely tuned to study the importance of these cues on tumorigenesis,» says coauthor Sandeep Koshy, a Harvard graduate student in the Harvard - MIT Program in Health Sciences and Technology, who works in Mooney's lab at Harvard SEAS and at the Wyss Institute for Biologically Inspired Engineering.

Interestingly, genomic analyses suggested that ESCC and head and neck squamous cell carcinoma (HNSCC) shared some common pathogenic mechanisms, and ESCC development is associated with alcohol drinking.These findings would provide a brand - new insight into the understandings of ESCC tumorigenesis, and would help clinicians to develop more effective diagnostic and therapeutic approaches for ESCC.

It has been known for a number of years that PREX2 is a GTP / GDP exchange factor that inhibits a tumor suppressor protein called PTEN, and that this process can promote tumorigenesis by activating the PI3K signaling pathway (Fine et al., 2009; Hodakoski et al., 2014; Figure 1A).

These findings would provide a brand - new insight into the understandings of ESCC tumorigenesis, and would help clinicians to develop more effective diagnostic and therapeutic approaches for ESCC.

For γ - radiation tumorigenesis, 1 - month - old mice were irradiated weekly for 4 weeks with a 1.75 - Gy dose from a 137Cs source (MARK 1 - 30 Irradiator; Shepherd & Associates) at a rate of 1.14 Gy / mFor γ - radiation tumorigenesis, 1 - month - old mice were irradiated weekly for 4 weeks with a 1.75 - Gy dose from a 137Cs source (MARK 1 - 30 Irradiator; Shepherd & Associates) at a rate of 1.14 Gy / mfor 4 weeks with a 1.75 - Gy dose from a 137Cs source (MARK 1 - 30 Irradiator; Shepherd & Associates) at a rate of 1.14 Gy / min.

Embryonic stem cells (ESCs) represent a source for the large numbers of modified EPCs required to therapeutically inhibit tumorigenesis [3], although patient - specific induced pluripotent stem cells (iPSCs) represent a more attractive option.

Blebbishields, the emergency program for cancer stem cells: sphere formation and tumorigenesis after apoptosis.

Cancer studies have increasingly focused on chromatin — the intertwined proteins and DNA that are packaged into chromosomes — because of its ability to regulate genes important for either activating or inhibiting tumorigenesis.

Smyd3 function is required for the activation of oncogenic pathways, cell proliferation and epithelial to mesenchymal transition during tumorigenesis.

These results also suggest a direct role for unphosphorylated STAT6 in tumorigenesis.

(2015) Fluorophore - NanoLuc BRET reporters enable sensitive in vivo optical imaging and flow cytometry for monitoring tumorigenesis.

Schaub, F.X., et al. (2015) Fluorophore - NanoLuc BRET reporters enable sensitive in vivo optical imaging and flow cytometry for monitoring tumorigenesis.

Although driver mutations were the main focus of cancer research for a long time, passenger mutational signatures, the imprints of DNA damage and DNA repair processes that have been operative during tumorigenesis, are also biologically illuminating.

Together, these data demonstrate that Stat5a is necessary for pregnancy - mediated promotion of preneoplastic cell survival, lesion progression, and tumorigenesis.

Estrogens are known for their proliferative effects on estrogen - sensitive tissues resulting in tumorigenesis.