Sentences with phrase «for tumour cells»

Other safety strategies include improving the specificity of CAR T - cells for tumour cells because healthy cells also carry CD - 19 receptors.

This is very important for the tumour cells which then spread into the surrounding nervous tissue.

The GCN2 - ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

Glutamine, though a non-essential amino acid, is critical for tumour cell proliferation.

A study published a couple of years ago, for example, showed that «chronic stress restructures lymphatic networks within and around tumours to provide pathways for tumour cell escape.»

Not exact matches

And a histogram of stiffness showed that as tumours become «pre-malignant», two peaks appear on the graph, rather than the single one observed for normal cells.

«This phase III trial will be noteworthy for being the first prostate cancer trial to assess a biomarker, namely AR - V7 in circulating tumour cells, as a predictor of response at the same time as testing the efficacy of the drug,» Prof Taplin will conclude.

This suggests that the presence of AR - V7 in circulating tumour cells does not preclude response to galeterone as has been shown to be the case for abiraterone and enzalutamide.»

«We are going to look for tumours, cell death and congestion in the organs that filter toxins,» she says.

In a revolutionary first, Cancer Research UK - funded scientists will test whether the Zika virus can destroy brain tumour cells, potentially leading to new treatments for one of the hardest to treat cancers.

RARE but pernicious cancer «stem» cells, blamed for the spread and invincibility of some tumours, may be more vulnerable than we thought.

He suggests, instead, that the team take T cells from the site of the tumour, because they would already be specialized for attacking cancer.

A «Trojan horse» treatment for an aggressive form of brain cancer, which involves using tiny nanoparticles of gold to kill tumour cells, has been successfully tested by scientists.

One reason for this is that the tumour cells invade surrounding, healthy brain tissue, which makes the surgical removal of the tumour virtually impossible.

We are looking for the proteins that make the tumour cells different to the host devils that they infect and then use these «tumour specific» proteins to design a vaccine that will save the devil from extinction.

Anne Goriely of the University of Oxford and her colleagues took tumour cells from men with benign testicular tumours and looked for specific mutations in the FGFR3 and HRAS genes.

How do the genetically diverse cells in a tumour interact, for example, and what is the role of the cellular environment that they inhabit?

Ironically, TRAIL normally delivers a signal for cells to die, but the Trinity scientists found that this molecule can also send a wound - healing message from tumour cells.

The ideal tool for diagnosis would be a non-invasive blood test; however, currently available tests only identify around three in five malignant germ cell tumours, potentially delaying diagnosis and the ability to prioritise patients for surgery.

The five year disease - free and overall survival rates for patients with high - risk malignant germ cell tumours remains less than 50 %, and so accurate diagnosis and monitoring is crucial to improving outcomes for patients.

In research funded by Sparks charity, Great Ormond Street Hospital Children's Charity and Cancer Research UK, researchers at the University of Cambridge have developed a test for blood and cerebrospinal fluid samples that looks for a specific panel of four pieces of short genetic code known as microRNAs, which are found in greater quantities in malignant germ cell tumours.

The test can be used for diagnosis of malignant germ cell tumours in any part of the body, including the brain.

Until now, it was not clear which form of cell death is decisive for the development of malignant liver tumours.

However, occasionally germ cells can get trapped in the wrong part of the body during development and may later turn into brain tumours, for example.

The time needed for breast cancer metastases (secondary lesions caused by cells that have escaped from the original tumour) to develop varies between patients, and little is known about the mechanisms that govern latency (the dormant state of cells that have already spread through the body).

In addition, they showed for the first time that these genes are often the same as those that are altered in breast tumours - when a tumour develops, the DNA within the cancer cells themselves mutates.

Mitochondria are the «engine» parts of the cells and are the source of energy for the stem cells as they mutate and divide to cause tumours.

For the first time ever, we could make a really comprehensive comparison of individual normal and tumour cells from the exact same type of tissue, taken at the same time, from the same person, and see how the cancer had developed.»

Dr Sophie Roerink, joint first author from the Wellcome Sanger Institute, said: «We found mutational processes in these cancer cells that are just not seen in normal cells, leading to a huge increase in mutation rate for tumours compared with normal cells.

The new device will allow for more accurate medical procedures that involve the use of ultrasound to kill tumours, loosen blood clots and deliver drugs into targeted cells.

But there's a catch: viruses and tumour cells can also exploit the UPR for their own ends, enabling them to grow at a faster rate and to thwart the body's immune response.

If these could be targeted to tumours — by attaching them to antibodies that recognise cancer cells, for instance — it would then be possible to destroy the malignant cells» DNA using lower doses of radiation or drugs.

The discovery could pave the way for new treatments that are able to block cell signals switched on in tumours with low levels of PTEN.

As well as looking for variations in the genome of different people's tumours, they also looked at the biological processes at work in the cells.

We did get some cells but they turned out to be tumour cells rather than the reprogrammed stem cells — known as induced pluripotent stem (iPS) cells — that we were hoping for.

Scientists from the Max Planck Institute for Heart and Lung Research in Bad Nauheim and Goethe University Frankfurt have now shown that tumour cells kill specific cells in the vascular wall.

Researchers from the University of Portsmouth's Brain Tumour Research Centre of Excellence have identified molecules which are responsible for metastatic lung cancer cells binding to blood vessels in the brain.

Professor Geoff Pilkington, study co-author and Head of the Brain Tumour Research Centre, said: «Although this work is still at an early stage, we have demonstrated key elements that are associated with tumour cell binding to blood vessels and this may provide a target for future drug development to prevent the development of secondary tumours in the Tumour Research Centre, said: «Although this work is still at an early stage, we have demonstrated key elements that are associated with tumour cell binding to blood vessels and this may provide a target for future drug development to prevent the development of secondary tumours in the tumour cell binding to blood vessels and this may provide a target for future drug development to prevent the development of secondary tumours in the brain.

It could have implications for HIV patients, both with and without cancer, as it can work on HIV reservoirs and tumour cells independently.

For example, if your topic is a gene that controls cancer cells, a description of sinister tumour growth in the relevant organ will probably do the trick.

«We have identified a number of pharmaceutical compounds that selectively inhibit — in different experimental models — the mitochondrial enzyme responsible for the tumour growth, thus limiting fat synthesis and without harming normal cells.»

A trained robotic surgeon experienced in the treatment of prostate, bladder and kidney cancer, Assoc Prof Chia said, «For anticancer drugs to achieve their best effectiveness, they need to penetrate into the tumour efficiently in order to reach the cystoplasm of all the cancer cells that are being targeted without affecting the normal cells.

The study, which is published in the journal Nature Communications, was conducted on human tumour cells and on mice, and offers hope of a much improved therapy for a severe form of cancer.

The team plans to test the approach in a clinical trial in which chemotherapy drug selection for each person will be guided by testing balls of their tumour cells in the lab.

«The high efficiency of the materials along with cheap, scalable synthesis makes them very attractive as next generation emitters for fluorescent lamps, LEDs and for biological imaging, for example for highlighting tumours or cell division.»

Brain cells are often found in ovarian teratomas, but it is extremely unusual for them to organise themselves into brain - like structures, says Masayuki Shintaku at the Shiga Medical Centre for Adults in Japan, who studied the tumour.

For these cells to be as useful as embryonic stem cells, «we have to find a way to avoid retroviruses before application in cell therapy», Yamanaka says, as they could result in tumours.

For cancer, he hopes to adopt a similar approach in which the transplanted nodes will contain T cells trained to hunt down the antigens produced by tumour cells and kill them off.

The researchers studied tumour tissue from patients, cultivated human tumour cells and tumours in mouse models for neuroblastoma.

For example, a gene called p53, which normally acts as a brake on cell division, turns out to be mutated or lost in about half of all tumours.