Because SLC6A14 is essential
for tumour growth yet dispensable for normal development and tissue maintenance, small molecules that block amino acid import through this transporter could be effective and selective anti-cancer agents, particularly as components of rational drug combinations.
Philadelphia, PA (Scicasts)-- Angiogenesis, the formation of new blood vessels, is essential
for tumour growth.
«We have identified a number of pharmaceutical compounds that selectively inhibit — in different experimental models — the mitochondrial enzyme responsible
for the tumour growth, thus limiting fat synthesis and without harming normal cells.»
This image highlights the key finding: that PTEN directly «destroys» PI (3,4) P2 and that PI (3,4) P2 is a marker
for tumour growth and progression.
Not exact matches
Radiation techniques were subsequently developed
for use after surgery to control small
tumour growths.
It's not all bad news, though: blocking this
growth pathway could buy time
for men with drug - resistant
tumours.
Blood vessel formation is also a critical step in the
growth and spreading of cancerous
tumours, as
tumours require a dedicated blood supply to provide the nutrients
for growth.
For example, if your topic is a gene that controls cancer cells, a description of sinister
tumour growth in the relevant organ will probably do the trick.
«Researchers discover a potential new therapeutic strategy
for pancreatic cancer: Researches have have isolated a subpopulation of cancer - associated fibroblasts, which promote
tumour growth.
Together with a partner from the industry, the research team successfully tested a vaccine from a new AAV mimotope library
for a
tumour antigen of breast cancer, the
growth factor HER2.
Scientists have identified
for the first time the «cell of origin» — in other words, the first cell from which the cancer grows — in basal cell carcinoma, the most common form of skin cancer, and followed the chain of events that lead to the
growth of these invasive
tumours.
In the future, scientists hope to target stem - cell - like cells within cancers that may be responsible
for most of the
growth of some
tumours, and evade existing drugs.
For analysis of
tumour growth over time, 1 × 106 B16F10 luciferase - positive cells were injected s.c. into the right flank of mice.
He added that, aside from the hope of creating replacement tissues and organs
for patients, the work could help scientists understand how to tackle unwanted blood vessel
growth, such as that found in
tumours.
Now, a research team at Imperial College London has found that in a mouse model developing liver cancer, one immunoreceptor — attractive candidate
for immunotherapies — promoted rather than delayed
tumour growth.
We have identified a novel amino acid transporter, SLC6A14, as a drug target
for cancer treatment; this transporter has functional features superior to those of SLC1A5, SLC7A5 and SLC7A11 to support
tumour growth.
The stem cell theory of cancer hypothesizes that «stem - like» cancer cells are responsible
for the generation of
tumours and
for sustaining
tumour growth (reviewed in ref.17).
Prof. Luis Liz - Marzan, EurASc Blaise Pascal Medalist in Materials Science in 2017, has received an ERC Advanced Grant
for his project entitled «Four - Dimensional Monitoring of
Tumour Growth by Surface Enhanced Raman Scattering» and this project will deal with the design of materials and methods that allow a study in real time of tumor growth under controlled environments, built from purposely designed scaf
Growth by Surface Enhanced Raman Scattering» and this project will deal with the design of materials and methods that allow a study in real time of tumor
growth under controlled environments, built from purposely designed scaf
growth under controlled environments, built from purposely designed scaffolds.
The study revealed that marine - derived omega - 3s are 8 times more effective
for the inhibition of
tumour growth and development.
Fasting has been shown to increase lifespan, slow
tumour growth and reduce the risk of developing diabetes [I have a history of diabetes in my family, so this is key
for me] and a host of other health benefits.
i have hypothyroidism and also a pituatry
tumour for which i inject myself with
growth hormone every night.i cant loose ant weight and my energy levels are very low, please can you advise
For example, glycine, amongst several other amino acids, is particularly useful for promoting cell growth: ideal in a baby, but not welcome in a cancerous tumo
For example, glycine, amongst several other amino acids, is particularly useful
for promoting cell growth: ideal in a baby, but not welcome in a cancerous tumo
for promoting cell
growth: ideal in a baby, but not welcome in a cancerous
tumour.
As boron is essential
for cell membranes and boron deficiency widespread, this may be an important cause
for the initiation of
tumour growth.
If the
tumour is larger, more invasive surgery will be necessary
for removal of the
growth, and possibly removal of the bone near to it.
for article Untangling the model muddle: Empirical
tumour growth in Tasmanian devil facial
tumour disease.