Sentences with phrase «for understanding human disease»

Since most of these proteins are also conserved in humans, having a better understanding of their function could have implications for understanding human disease.

(Drosophila, or fruit flies, are a frequently used model for understanding human disease, and oskar is critical for normal development of fruit fly embryos.)

Not exact matches

What it does: The role of this bacteria, which is most well - known for causing syphilis and Lyme disease, is still not well - understood in humans.

We must take a clear view of the medical realities of disease and the spiritual realities of sin, but it makes a difference in the pastor's understanding of all human ills that he sees every person as created for a life of love to God and his neighbor.

«These new insights into the complexities of epigenetic regulation are contributing to our basic understanding of this process in human health and disease and gives us new vision for how to go about targeting errors in DNA methylation with innovative drug therapies.»

To better understand their findings, the team examined the animal model for APS1 (i.e. mice with the same genetic defect as human patients with the syndrome) and found that male mice spontaneously developed an inflammatory disease in their prostate glands — a so - called prostatitis — and reacted to transglutaminase 4.

Human tissue grown in the laboratory offers a critical model for understanding the disease process.

If we are looking for the real engine for infection — the driver of the disease factory, if you like — we have to understand what human - to - human transmission is, and how it turns an animal disease into a human one.

With our human gut - on - a-chip, we can not only culture the normal gut microbiome for extended times, but we can also analyze contributions of pathogens, immune cells, and vascular and lymphatic endothelium, as well as model specific diseases to understand complex pathophysiological responses of the intestinal tract.»

«It has profound implications for our understanding of human development and physiology, and gives us a remarkable wealth of resources to examine how disturbances of this system might result in diseases such as cancer.»

Buttke is interested in using public interest in personal health as a way to increase support for public green space, and enhancing public understanding of how human actions can drive infectious disease spread through a variety of avenues including school programs, websites, and smart phone apps.

«Once we can build that sort of database for the human organism, it helps us much better understand disease, how to diagnose disease, how better to treat disease,» says Richard Wilson, the director of the Genome Sequencing Center at Washington University in St. Louis.

But understanding the disease also has important implications for human health.

Research into how the brain processes time, sound and movement has implications for understanding how humans listen to music and speech, as well as for treating diseases like Parkinson's.

These observations and others have convinced the researchers that their CRISPR / Cas9 and hPSC system produces a stable, biologically accurate human model for a common genetic disease where new understanding and new therapies are desperately needed.

These developments have created countless opportunities for advancing our understanding and treating human disease.

Researches are now able to understand for the first time the evolution of these parasites, causing disease in humans and animals.

The physician - scientist may study the same properties of the same molecule but for a different reason: because he or she believes that those studies will provide information on the fundamental pathology of a disease or insight into human biology that will provide a better understanding of healthy versus diseased states.

«Further work in our lab will be aimed at understanding the detailed mechanism of how these proteins regulate editing, in turn providing an inroad to developing therapeutics that modulate editing for the treatment of human diseases.»

This will allow to understand more about genes we currently know very little about, and open up new avenues for research into the genetics of human disease.

«Understanding this previously ignored part of the human genome, its role in human development, and how it may be taken over by disease, opens a new frontier in science with important implications for medical advances,» said Philipp Kapranov, Ph.D., lead researcher at the St. Laurent Institute.

Mini-organ models promise enormous advantages for understanding basic human biology, teasing apart human disease processes, and offering an accurate testing ground for finding or vetting drug therapies.

Understanding these redundancies, and how to bypass them, could be important for biomedical researchers wishing to manipulate gene activity to treat human diseases.

«If we can improve our ability to read and understand the human genome, we will also be able to make better use of the rapidly accumulating genomic information on a large number of diseases for medical benefits.»

NIH gets an extra $ 414 million for Alzheimer's disease research, along with $ 400 million for the BRAIN Initiative, a research project announced by President Obama in 2013 that aims to improve our understanding of the human brain.

His research interests include the molecular underpinnings of cervical cancer (including developing genetic screens), the identification of the genetic determinants of quantitative traits in humans, and the application of massively parallel sequencing technology for understanding the genetics of complex disease.

Because of the similarities in ocular anatomy, canine models contribute significantly to the understanding of retinal disease mechanisms and the development of new therapies for human patients.

From there, he moved to the Medical Genetics Institute at Cedars - Sinai Medical Center, trying to understand the molecular basis for human skeletal diseases.

The European Union's $ 1.1 billion Human Brain Project, for example, aims to understand the brain as a single system, integrating multiple levels of organisation — surely a key step towards preventing or curing psychiatric diseases.

However, since the novel genes that were identified, are known to lead to aging - associated diseases in humans, their further analysis seems to be promising for developing new approaches to understand and possibly cure these diseases and to contribute to a long life and healthy aging in humans — in a way, long - lived rodents do.

«The study of ancient microbiomes helps us understand the evolutionary history of human health and disease,» says Professor Frank Rühli, a senior author of the study and Head of the Centre for Evolutionary Medicine at the University of Zürich.

«Our work will help us understand the underlying mechanisms and etiology for these debilitating human diseases.»

It's not all just fun and games: Understanding how cells — especially white blood cells — navigate through the human body could help scientists create better treatments for cancer, infectious disease, and autoimmune disorders.

The study has wide reaching implications for understanding the evolution of the human oral microbiome and the origins of periodontal disease.

«For 15 years, an impressive amount of time and money poured into discovering the genomes of mammals, motivated by our drive to understand human evolution and to look for cures for diseaFor 15 years, an impressive amount of time and money poured into discovering the genomes of mammals, motivated by our drive to understand human evolution and to look for cures for diseafor cures for diseafor disease.

«Aberrant splicing in humans may lead to various complex diseases and also underlies the development of some forms of cancer and the onset of neurodegenerative diseases, so a better understanding of the process can add important information for our fight against these diseases.»

The research has implications for understanding chronic, complex human diseases over time.

Overall, this work illustrates that better understanding the basic biology of the immune system in preclinical models may open up a window for the development of novel treatments for human autoimmune disease.

«Our findings also have important implications for mitochondrial diseases in humans, because this research significantly advances our understanding of how mitochondrial DNA mutations affect individuals and populations, and provides a potential mechanism to explain how different genetic variants may affect health,» Dr Rollins said.

Richard Lindsay, a PhD student who worked on the research team, added: «Our findings are of central importance in understanding how microbial infections evolve, but also have wider significance for the treatment of cancer and the therapeutic control of disease in humans, animals and plants.»

Because many rabbit genes are similar to their human counterparts, manipulating disease genes in rabbits, like the one responsible for cystic fibrosis, may permit researchers to track the disease's onset and better understand what goes awry.

The discovery of cells» ultra-sensitivity for mechanical property of their environment is crucial to understanding basic physiological processes that underlie embryo development, tumor metastasis, wound healing and many other aspects of human health and disease.

«Fish eyes to help understand human inherited blindness: Discovery of a gene in zebrafish that triggers congenital blindness could lead to a suitable cure for similar disease in humans..»

But it's extremely important for understanding fatal diseases in humans, especially those caused by ageing,» said Professor David Gems (UCL Institute of Healthy Ageing), who led the team of researchers.

As described in the journal Neurology, Drexel University and Boston University recently received funding from the U.S. Department of Defense to create a Gulf War Illness human stem cell repository, to be shared with researchers across the country for a deeper understanding of this disease.

This discovery provides a significant opportunity not only to enhance our understanding of how miRNAs regulate a variety of biological processes in an important model species for studying human diseases, but can lead to further, similar research into the role that miRNAs play in animal domestication.

A detailed analysis of this mechanism will be crucial to understand how aggregate - forming proteins lead to human diseases and may help to develop concepts for possible disease preventions.

Theoretically, this precise molecular characterization of human disease will allow us to understand the basis for disease susceptibility and environmental influence; to offer an explanation for the different phenotypic manifestations of the same disease; to define disease prognosis with greater accuracy; and to refine and, ideally, individualize disease treatment for optimal therapeutic efficacy.

This has proven to be one of the most powerful ways of identifying the parts of the human genome that are most functionally important, and therefore most likely to be relevant for an understanding of disease.

The researchers» strategy — generating disease - specific nerve cells, identifying a causative gene for developmental defects, validating the gene - specific defect in animal models, and then investigating interactions with other genes both in animal models and in humans — represents a promising new approach for understanding the mechanisms underlying some of the most intractable psychiatric illnesses.